Zobrazeno 1 - 10
of 41
pro vyhledávání: '"CNS hypomyelination"'
Publikováno v:
Brain and Behavior
Brain and Behavior, Vol 11, Iss 10, Pp n/a-n/a (2021)
Brain and Behavior, Vol 11, Iss 10, Pp n/a-n/a (2021)
Background Platelet‐derived growth factor (PDGF) signaling, through the ligand PDGF‐A and its receptor PDGFRA, is important for the growth and maintenance of oligodendrocyte progenitor cells (OPCs) in the central nervous system (CNS). PDGFRA sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbabff5cfa91822c403ca33e4f8c9e4f
http://europepmc.org/articles/PMC8553322
http://europepmc.org/articles/PMC8553322
Autor:
Matthew R. Livesey, Isaac H. Bianco, Megan E Madden, Daumante Suminaite, Sigrid Koudelka, David A. Lyons, Michael Granato, Elelbin A. Ortiz, Jason J Early
Publikováno v:
The Journal of Neuroscience
Madden, M, Suminaite, D, Ortiz, E, Early, J, Koudelka, S, Livesey, M, Bianco, I H, Granato, M & Lyons, D A 2021, ' CNS Hypomyelination Disrupts Axonal Conduction and Behavior in Larval Zebrafish ', The Journal of Neuroscience . https://doi.org/10.1523/JNEUROSCI.0842-21.2021
Madden, M, Suminaite, D, Ortiz, E, Early, J, Koudelka, S, Livesey, M, Bianco, I H, Granato, M & Lyons, D A 2021, ' CNS Hypomyelination Disrupts Axonal Conduction and Behavior in Larval Zebrafish ', The Journal of Neuroscience . https://doi.org/10.1523/JNEUROSCI.0842-21.2021
Myelination is essential for central nervous system (CNS) formation, health and function. As a model organism, larval zebrafish have been extensively employed to investigate the molecular and cellular basis of CNS myelination, because of their geneti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55872f7b31c32f475951f0e1b81b4ff9
https://pubmed.ncbi.nlm.nih.gov/34544838
https://pubmed.ncbi.nlm.nih.gov/34544838
Autor:
Elly Verbeek, Hinrich W. H. Göhlmann, Marion Crauwels, Dieder Moechars, Frans W. Verheijen, Rachel Schot, Rudi D'Hooge, Nathalie Van Acker, Stijn Stroobants, An De Bondt, Grazia M.S. Mancini, Luc Andries, Guy Daneels, Michiel W.M. Knaapen, Ilse Goris
Publikováno v:
Experimental Neurology. 291:106-119
Slc17a5(-/-) mice represent an animal model for the infantile form of sialic acid storage disease (SASD). We analyzed genetic and histological time-course expression of myelin and oligodendrocyte (OL) lineage markers in different parts of the CNS, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::470d22f55e736a062f60e44e37c917fd
Gab1 mediates PDGF signaling and is essential to oligodendrocyte differentiation and CNS myelination
Autor:
Ying Shen, Yue Hai Ke, Mengsheng Qiu, Ya-Jun Xie, Zhi-Ying Wu, Ben-Yan Luo, Chong-Yu Shao, Liang Zhou, Si-Min Xu, Na Wang
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
Oligodendrocytes (OLs) myelinate axons and provide electrical insulation and trophic support for neurons in the central nervous system (CNS). Platelet-derived growth factor (PDGF) is critical for steady-state number and differentiation of oligodendro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45887cab99e7046d16a69dd0a2188a59
https://doi.org/10.7554/elife.52056
https://doi.org/10.7554/elife.52056
Autor:
Peter Kuzman, Jennifer A. Barrie, Fredrik I. Gruenenfelder, James Y. Garbern, M. C. McCulloch, Klaus-Armin Nave, Gemma Thomson, Ruth M. Stassart, Mark McLaughlin, Jacques Penderis, Julia M. Edgar, Ian R. Griffiths
Publikováno v:
Brain
Gruenenfelder et al. report that direct neural stem cell transplantation in an animal model of Pelizaeus-Merzbacher disease restores normal myelin in the face of competition from myelin-competent mutant oligodendrocytes. These data have implications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a20e23044efcafc17d4c8de1334bdaf5
Autor:
Miki Furusho, Joshay Ford, Jessica W. Tutolo, Kristine H. Le, Rashmi Bansal, Michael J. Maggipinto, Elisa Barbarese, John W Wizeman
Publikováno v:
Glia. 65:489-501
The tumor overexpressed gene (TOG) protein is present in RNA granules that transport myelin basic protein (MBP) mRNA in oligodendrocyte processes to the myelin compartment. Its role was investigated by conditionally knocking it out (KO) in myelinatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85493c7dcc24db7200a76a4cc65d5eec
https://doi.org/10.1002/glia.23106
https://doi.org/10.1002/glia.23106
Publikováno v:
The Journal of Neuroscience. 36:4106-4120
RNA binding proteins required for the maintenance of myelin and axoglial junctions are unknown. Herein, we report that deletion of the Quaking (QKI) RNA binding proteins in oligodendrocytes (OLs) usingOlig2–Creresults in mice displaying rapid tremo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45a6235a88d13e4a4eab44a670d97117
https://doi.org/10.1523/jneurosci.3529-15.2016
https://doi.org/10.1523/jneurosci.3529-15.2016
Autor:
Corinne Bachelin, Brahim Nait Oumesmar, Ana C. Temporão, Melissa Fauveau, Karelle Benardais, Cyrille Deboux, Christophe Kerninon, Baptiste Wilmet
Publikováno v:
Glia. 66(10)
Oligodendrocyte development is a critical process timely and spatially regulated to ensure proper myelination of the central nervous system. HMG-box transcription factors are key regulators of oligodendrocyte lineage progression. Among these factors,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61efbbf63feeea9e242fc3d9dbeefdc9
https://pubmed.ncbi.nlm.nih.gov/30152028
https://pubmed.ncbi.nlm.nih.gov/30152028
Autor:
Yang I. Li, Qili Fei, Rejani B. Kunjamma, Yulia Dzhashiashvili, Joshua S. Jones, Benayahu Elbaz, Xiaoxi Zhuang, Huan Xu, Brian Popko, Yi Lan Weng, Guo Li Ming, Chuan He, Ankeeta Shah
Publikováno v:
Neuron. 105:293-309.e5
Summary The molecular mechanisms that govern the maturation of oligodendrocyte lineage cells remain unclear. Emerging studies have shown that N6-methyladenosine (m6A), the most common internal RNA modification of mammalian mRNA, plays a critical role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f96ecd7fb58f03b3303d36188cc7065d
https://doi.org/10.1016/j.neuron.2019.12.013
https://doi.org/10.1016/j.neuron.2019.12.013
Autor:
Miriam H. Meisler, Leif A. Havton, Peter Shrager, Jing-Ping Lin, Yevgeniya A. Mironova, Alessandra Bolino, Roman J. Giger, Ilaria Vaccari, Charles S. Abrams, Sang H. Min, Jeffery L. Twiss, Seung Joon Lee, Guy M. Lenk
Publikováno v:
eLife
eLife, Vol 5 (2016)
eLife, Vol 5 (2016)
Proper development of the CNS axon-glia unit requires bi-directional communication between axons and oligodendrocytes (OLs). We show that the signaling lipid phosphatidylinositol-3,5-bisphosphate [PI(3,5)P2] is required in neurons and in OLs for norm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32f98a8d19b5f8465ad2a1132abe605f
https://doi.org/10.7554/elife.13023
https://doi.org/10.7554/elife.13023