Zobrazeno 1 - 10
of 28
pro vyhledávání: '"CNS PHARMACOLOGY"'
Publikováno v:
Biochemical Pharmacology. 168:162-172
MicroRNAs (miRNAs) represent a class of important post-transcriptional regulators of gene expression, enabling cells to follow their intrinsic developmental program. By directly binding to their targets, miRNAs can both promote transcriptional patter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5a9f549c35c5deb4057517af8263c58
https://doi.org/10.1016/j.bcp.2019.06.019
https://doi.org/10.1016/j.bcp.2019.06.019
Autor:
Robert Newman, Benjamin G. Tehan, J.D. Brown, Richard Mould, Alicia P. Higueruelo, K.A. Bennett, O'brien Michael Alistair, Flavia Autore, Cliona MacSweeney, Heather Currinn, Cheryl A. Brighton, Lisa A. Stott, Steve P. Watson
Publikováno v:
Heliyon
Heliyon, Vol 7, Iss 6, Pp e07201-(2021)
Heliyon, Vol 7, Iss 6, Pp e07201-(2021)
The identification of cannabinoid ligands Cannabidiol and O-1918 as inverse agonists of the orphan receptor GPR52 is reported. Detailed characterisation of GPR52 pharmacology and modelling of the proposed receptor interaction is described. The identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74e712b64596b5eaa25e6dd34e58553b
https://pubmed.ncbi.nlm.nih.gov/34189291
https://pubmed.ncbi.nlm.nih.gov/34189291
Publikováno v:
Advances in Neurobiology ISBN: 9783319283814
India has traditionally been known to all over the world for spices and medicinal plants. Spices exhibit a wide range of pharmacological activities. In contemporary, Indian spices are used to rustle up delicious delicacies. However, the Indian spices
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb8c44db727df4e83f792877782ddadb
https://doi.org/10.1007/978-3-319-28383-8_4
https://doi.org/10.1007/978-3-319-28383-8_4
Autor:
Andreas Reichel
Publikováno v:
Current Drug Metabolism. 7:183-203
The blood-brain barrier (BBB) remains one of the greatest challenges for the discovery and development of treatments for CNS disorders, which to this day remains one of the riskiest disease areas in terms of clinical success rates. Although the BBB i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::593a6a64b6dc67c0c9604a902fb8af6f
https://doi.org/10.2174/138920006775541525
https://doi.org/10.2174/138920006775541525
Autor:
Michael F. James, R.A. Leslie
Publikováno v:
Trends in Pharmacological Sciences. 21:314-318
Various methods, including functional magnetic resonance imaging (fMRI), have recently been developed to allow investigators to study functional activity in the living brain. Such techniques are now being used to investigate regionally specific brain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54deadaf73d2eb721b432da6961de20e
https://doi.org/10.1016/s0165-6147(00)01507-8
https://doi.org/10.1016/s0165-6147(00)01507-8
Publikováno v:
Drugs. 50:971-983
The 21-aminosteroids (lazaroids) are inhibitors of lipid membrane peroxidation and appear to function as oxygen free radical scavengers. The therapeutic potential of the lazaroid tirilazad mesylate has been extensively studied in several CNS disorder
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2ae0696724c98f10215f030abbd456f
https://doi.org/10.2165/00003495-199550060-00005
https://doi.org/10.2165/00003495-199550060-00005
Publikováno v:
The FASEB Journal. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23cc57e7e502900dd9b90bc8d136ecb4
https://doi.org/10.1096/fasebj.23.1_supplement.463.11
https://doi.org/10.1096/fasebj.23.1_supplement.463.11
Akademický článek
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Publisher Summary This chapter describes the actions of gangliosides on the central nervous system (CNS) in vivo , the effective doses, and their penetration into the brain. It is demonstrated that exogenous gangliosides could reduce the injury and f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d30bc29fec3577ba6f657234cfd74218
https://doi.org/10.1016/s0079-6123(08)61960-3
https://doi.org/10.1016/s0079-6123(08)61960-3
Autor:
David J. Nutt
Publikováno v:
Current Aspects of the Neurosciences ISBN: 9781349119240
We are all familiar with the term benzodiazepine, as are a significant proportion of the general public. In the public domain it is a term synonymous with diazepam that connotes dependence and withdrawal. The scientific community also has its misconc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82977d39cffe55d70ec3835136cda974
https://doi.org/10.1007/978-1-349-11922-6_9
https://doi.org/10.1007/978-1-349-11922-6_9