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Dissecting the Landscape of Activated CMV-Stimulated CD4+ T Cells in Humans by Linking Single-Cell RNA-Seq With T-Cell Receptor Sequencing

Autor: Menghua Lyu, Shiyu Wang, Kai Gao, Longlong Wang, Xijun Zhu, Ya Liu, Meiniang Wang, Xiao Liu, Bin Li, Lei Tian

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

CD4+ T cells are crucial in cytomegalovirus (CMV) infection, but their role in infection remains unclear. The heterogeneity and potential functions of CMVpp65-reactivated CD4+ T cell subsets isolated from human peripheral blood, as well as their pote

Externí odkaz: https://doaj.org/article/53a9bd0d77954e7a94bf0f97036ac8e9

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Definição do ponto de corte da carga viral quantitativa do citomegalovírus para o tratamento preemptivo baseado na correlação com a antigenemia pp65, cinética viral e desfecho clínico em receptores de transplante cardíaco

Autor: Telles, Paula Fernanda Gomes, 1984

Publikováno v: Biblioteca Digital de Teses e Dissertações da Universidade Estadual de Campinas (UNICAMP)
Universidade Estadual de Campinas (UNICAMP)
instacron:UNICAMP

Orientadores: Mariângela Ribeiro Resende, Sandra Cecília Botelho Costa Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas Resumo: Embora as diferentes estratégias de monitorização do Citomegalovírus (C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0555c7e5f09334d12cb8edd9852972fb
https://doi.org/10.47749/t/unicamp.2015.960239

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Gene Expression-Based Identification of Antigen-Responsive CD8+ T Cells on a Single-Cell Level

Autor: Yannick F. Fuchs, Virag Sharma, Anne Eugster, Gloria Kraus, Robert Morgenstern, Andreas Dahl, Susanne Reinhardt, Andreas Petzold, Annett Lindner, Doreen Löbel, Ezio Bonifacio

Publikováno v: Frontiers in Immunology, Vol 10 (2019)
Frontiers in Immunology
Front. Immunol. 10:2568 (2019)

CD8+ T cells are important effectors of adaptive immunity against pathogens, tumors and self antigens. Here, we asked how human cognate antigen-responsive CD8+ T cells and their receptors could be identified in unselected single-cell gene expression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f908a52d07dd39b9ba9207d42b9a346
https://doi.org/10.3389/fimmu.2019.02568

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The Value of Persistent Cytomegalovirus Infection in the Formation of Groups of Children with Recurrent Acute Respiratory Diseases

Autor: Array А. Сотников, Array А. Вальтц, Array А. Кущ, Array В. Чичаев, Array Ю. Егорова

Publikováno v: Detskie Infekcii (Moskva), Vol 14, Iss 4, Pp 13-16 (2015)

So far not defined the value of CMV persistence in frequently and chronically ill children, the impact of active CMV-infection on the severity of the condition and the incidence of viral-bacterial complications. 149 surveyed frequently and long ill c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03ed0640a04c27f4faaf40f62cee8660
https://detinf.elpub.ru/jour/article/view/178

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Correlations of programmed death 1 expression and serum IL-6 level with exhaustion of cytomegalovirus-specific T cells after allogeneic hematopoietic stem cell transplantation

Autor: Makoto Murata, Miho Murase, Tetsuya Nishida, Tomonori Kato, Tomoki Naoe, Yoshinori Ito

Publikováno v: Cellular Immunology. 288:53-59

The effect of programmed death 1 (PD-1) on cytomegalovirus (CMV)-specific T cells has not been thoroughly examined. We evaluated the involvement of exhausted CMV-specific T cells in persistent CMV infection after allogeneic hematopoietic stem cell tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee4ee10972781d20652fe054dd615e33
https://doi.org/10.1016/j.cellimm.2014.02.007

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Avidity characterization of genetically engineered T-cells with novel and established approaches

Autor: Victoria Hillerdal, Hanna Björkelund, Karl Andersson, Magnus Essand, Vanessa F. Boura

Publikováno v: BMC Immunology

Background: Adoptive transfer of genetically engineered autologous T-cells is becoming a successful therapy for cancer. The avidity of the engineered T-cells is of crucial importance for therapy success. We have in the past cloned a T-cell receptor (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cafed2df07737766c79dbfd213e5c4bc
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-300454

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