T2 Subphenotypes in patients with severe acute respiratory failure requiring extracorporeal membrane oxygenation

Autor: K Reddy, JE Millar, MV Malfertheiner, P Sinha, D Antcliffe, CS Calfee, CM O’Kane, T Müller, DF McAuley

Publikováno v: Joint BTS/BALR/A+L UK Early Career Investigator Symposium.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::260a0d58d5faeb76aeb645fdce6093f3
https://doi.org/10.1136/thorax-2022-btsabstracts.2

Mechanical Stretch Induces Senescence of Lung Epithelial Cells and Drives Fibroblast Activation by Paracrine Mechanisms.

Autor: Martín-Vicente P; Instituto de Investigación Sanitaria del Principado de Asturias, Oviedo, Spain.; Universidad de Oviedo, Oviedo, Asturias, Spain., López-Martínez C; Instituto de Investigación Sanitaria del Principado de Asturias, Oviedo, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain., López-Alonso I; Instituto de Investigación Sanitaria del Principado de Asturias, Oviedo, Spain.; Centro de Investigación Biomédica en Red, Enfermedades Respiratorias, Madrid, Spain., Exojo-Ramírez SM; Instituto de Investigación Sanitaria del Principado de Asturias, Oviedo, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain., Duarte-Herrera ID; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain., Amado-Rodríguez L; Hospital Universitario Central de Asturias, Cardiac Intensive Care Unit, Oviedo, Spain.; Instituto de Investigación Sanitaria del Principado de Asturias, Oviedo, Spain.; Centro de Investigación Biomédica en Red, Enfermedades Respiratorias, Madrid, Spain., Ordoñez I; Universidad de Oviedo, Oviedo, Asturias, Spain., Cuesta-Llavona E; Hospital Universitario Central de Asturias, Genetics, Oviedo, Spain., Gómez J; Hospital Universitario Central de Asturias, Genetics, Oviedo, Spain., Campo N; Instituto de Investigación Sanitaria del Principado de Asturias, Oviedo, Spain., O'Kane CM; Queen's University of Belfast, Centre for Infection and Immunity, Belfast, N. Ireland, United Kingdom of Great Britain and Northern Ireland.; United Kingdom of Great Britain and Northern Ireland., McAuley DF; University of Belfast, Belfast, United Kingdom of Great Britain and Northern Ireland., Huidobro C; Universidad de Oviedo, Oviedo, Asturias, Spain., Albaiceta GM; Hospital Universitario Central de Asturias, Department of Functional Biology, Oviedo, Asturias, Spain; gma@crit-lab.org.

Publikováno v: American journal of respiratory cell and molecular biology [Am J Respir Cell Mol Biol] 2024 Aug 12. Date of Electronic Publication: 2024 Aug 12.

Patient stratification using plasma cytokines and their regulators in sepsis: relationship to outcomes, treatment effect and leucocyte transcriptomic subphenotypes.

Autor: Antcliffe DB; Division of Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK d.antcliffe@imperial.ac.uk.; Centre for Perioperative and Critical Care Research, Imperial College Healthcare NHS Trust, London, UK., Mi Y; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Santhakumaran S; Imperial Clinical Trials Unit, School of Public Health, Imperial College London, London, UK., Burnham KL; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Prevost AT; Nightingale-Saunders Clinical Trials and Epidemiology Unit, King's College London, London, UK., Ward JK; Conway Institute, School of Medicine, University College Dublin, Dublin, Ireland., Marshall TJ; Department of Anaesthetics, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.; Central Clinical School Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia., Bradley C; Division of Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK., Al-Beidh F; Division of Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK., Hutton P; Adult Intensive Care Unit, John Radcliffe Hospital, Oxford, UK., McKechnie S; Adult Intensive Care Unit, John Radcliffe Hospital, Oxford, UK., Davenport EE; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Hinds CJ; William Harvey Research Institute, Barts & The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., O'Kane CM; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK., McAuley DF; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK.; Regional Intensive Care Unit, Royal Victoria Hospital, Belfast, UK.; Northern Ireland Clinical Trials Unit, Royal Hospitals, Belfast, UK., Shankar-Hari M; The Queen's Medical Research Institute, The University of Edinburgh College of Medicine and Veterinary Medicine, Edinburgh, UK.; Intensive Care Unit, Royal Infirmary of Edinburgh, Edinburgh, UK., Gordon AC; Division of Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK.; Centre for Perioperative and Critical Care Research, Imperial College Healthcare NHS Trust, London, UK., Knight JC; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK.

Publikováno v: Thorax [Thorax] 2024 May 20; Vol. 79 (6), pp. 515-523. Date of Electronic Publication: 2024 May 20.

Cell-based Therapies for Acute Respiratory Distress Syndrome: Where Are We Now?

Autor: Curley GF; Department of Anaesthesia, Royal College of Surgeons in Ireland, Dublin, Ireland., O'Kane CM; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, United Kingdom., McAuley DF; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, United Kingdom.; Department of Critical Care, Belfast Health and Social Care Trust, Belfast, United Kingdom., Matthay MA; Department of Medicine and Department of Anesthesia, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California., Laffey JG; Department of Anaesthesia and Intensive Care Medicine, Galway University Hospitals, Saolta University Healthcare System, Galway, Ireland; and.; Anaesthesia, School of Medicine, College of Medicine, Nursing and Health Sciences, and CÚRAM Centre for Research in Medical Devices, University of Galway, Galway, Ireland.

Publikováno v: American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2024 Apr 01; Vol. 209 (7), pp. 789-797.

Elevated ferritin, mediated by IL-18 is associated with systemic inflammation and mortality in acute respiratory distress syndrome (ARDS).

Autor: Mehta P; Centre for inflammation and Tissue Repair (CITR), University College London Division of Medicine, London, UK., Samanta RJ; Department of Medicine, University of Cambridge, Cambridge, UK., Wick K; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California, USA., Coll RC; Wellcome Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK., Mawhinney T; Wellcome Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK., McAleavey PG; Wellcome Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK., Boyle AJ; Wellcome Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK.; Royal Victoria Hospital, Belfast Health and Social Care Trust, Belfast, UK., Conlon J; Wellcome Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK., Shankar-Hari M; The Queen's Medical Research Institute, Edinburgh BioQuarter, Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK.; Intensive Care Medicine, Royal Infirmary of Edinburgh, NHS Lothian, Edinburgh, UK., Rogers A; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Stanford University, Stanford, California, USA., Calfee CS; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California, USA.; Departments of Medicine and Anesthesia, University of California, San Francisco, San Francisco, California, USA., Matthay MA; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California, USA.; Departments of Medicine and Anesthesia, University of California, San Francisco, San Francisco, California, USA., Summers C; Department of Medicine, University of Cambridge, Cambridge, UK., Chambers RC; Centre for Inflammation and Tissue Repair, UCL, London, UK., McAuley DF; Wellcome Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK.; Royal Victoria Hospital, Belfast Health and Social Care Trust, Belfast, UK., O'Kane CM; Wellcome Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK c.okane@qub.ac.uk.

Publikováno v: Thorax [Thorax] 2024 Feb 15; Vol. 79 (3), pp. 227-235. Date of Electronic Publication: 2024 Feb 15.