Correlation of Optical and Automated Patch Clamp Electrophysiology for Identification of Na V 1.7 Inhibitors.

Autor: Zhang H; Q-State Biosciences, Cambridge, MA, USA., Moyer BD; Neuroscience, Amgen Research, Thousand Oaks, CA, USA., Yu V; Neuroscience, Amgen Research, Cambridge, MA, USA., McGivern JG; Discovery Technologies, Amgen Research, South San Francisco, CA, USA., Jarosh M; Neuroscience, Amgen Research, Cambridge, MA, USA., Werley CA; Q-State Biosciences, Cambridge, MA, USA., Hecht VC; Q-State Biosciences, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Babcock RJ; Q-State Biosciences, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Dong K; Q-State Biosciences, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Dempsey GT; Q-State Biosciences, Cambridge, MA, USA., McManus OB; Q-State Biosciences, Cambridge, MA, USA., Hempel CM; Q-State Biosciences, Cambridge, MA, USA.; Expressive Neuroscience, Syracuse, NY, USA.

Publikováno v: SLAS discovery : advancing life sciences R & D [SLAS Discov] 2020 Jun; Vol. 25 (5), pp. 434-446. Date of Electronic Publication: 2020 Apr 15.

Upregulation of μ3A Drives Homeostatic Plasticity by Rerouting AMPAR into the Recycling Endosomal Pathway.

Autor: Steinmetz CC; Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA., Tatavarty V; Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA., Sugino K; Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA., Shima Y; Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA., Joseph A; Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA., Lin H; Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA., Rutlin M; Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA., Lambo M; Department of Brain and Cognitive Science, MIT, Cambridge, MA 02139, USA., Hempel CM; Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA., Okaty BW; Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA., Paradis S; Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA., Nelson SB; Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA. Electronic address: nelson@brandeis.edu., Turrigiano GG; Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA. Electronic address: turrigiano@brandeis.edu.

Publikováno v: Cell reports [Cell Rep] 2016 Sep 06; Vol. 16 (10), pp. 2711-2722. Date of Electronic Publication: 2016 Aug 25.

Cell-type-specific repression by methyl-CpG-binding protein 2 is biased toward long genes.

Autor: Sugino K; Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, Massachusetts 02454, and Janelia Farm Research Campus, Ashburn, Virginia 20147 suginok@janelia.hhmi.org nelson@brandeis.edu., Hempel CM; Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, Massachusetts 02454, and., Okaty BW; Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, Massachusetts 02454, and., Arnson HA; Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, Massachusetts 02454, and., Kato S; Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, Massachusetts 02454, and., Dani VS; Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, Massachusetts 02454, and., Nelson SB; Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, Massachusetts 02454, and suginok@janelia.hhmi.org nelson@brandeis.edu.

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2014 Sep 17; Vol. 34 (38), pp. 12877-83.

A system for performing high throughput assays of synaptic function.

Autor: Hempel CM; Galenea Corporation, Cambridge, Massachusetts, United States of America., Sivula M, Levenson JM, Rose DM, Li B, Sirianni AC, Xia E, Ryan TA, Gerber DJ, Cottrell JR

Publikováno v: PloS one [PLoS One] 2011; Vol. 6 (10), pp. e25999. Date of Electronic Publication: 2011 Oct 05.

A manual method for the purification of fluorescently labeled neurons from the mammalian brain.

Autor: Hempel CM; Department of Biology and National Center for Behavioral Genomics, Brandeis University, MS 008, 415 South Street, Waltham, Massachusetts 02454-9110, USA., Sugino K, Nelson SB

Publikováno v: Nature protocols [Nat Protoc] 2007; Vol. 2 (11), pp. 2924-9.