Extracellular vesicle activities regulating macrophage- and tissue-mediated injury and repair responses

Autor: Wen-Fu Tang, Jesse K. Fletcher, Tony Y. Hu, Christopher J. Lyon, Mei-Hua Wan, Qian Hu

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 6, Pp 1493-1512 (2021)

Macrophages are typically identified as classically activated (M1) macrophages and alternatively activated (M2) macrophages, which respectively exhibit pro- and anti-inflammatory phenotypes, and the balance between these two subtypes plays a critical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3ea92a17df434fa277efb35adc11fe4
https://doi.org/10.1016/j.apsb.2020.12.014

γ-glutamylcysteine exhibits anti-inflammatory effects by increasing cellular glutathione level

Autor: Zhimin Yin, Qiyun Hang, Yang Yang, Lan Luo, Peng Cao, Xiaoliang Dong, Ling Li, Yuan Fang

Publikováno v: Redox Biology, Vol 20, Iss, Pp 157-166 (2019)
Redox Biology

Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to infection and characterized by redox imbalance and severe oxidative stress. Glutathione (GSH) serves several vital functions, including scavenging free radicals an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae683ecc0cc66bb2849c7654b0119182
http://www.sciencedirect.com/science/article/pii/S221323171830836X

Subtribe Hyptidinae: a promising source of bioactive metabolites

Autor: Gabriela de Carvalho Meirelles, Gilsane Lino von Poser, Henrique Bridi

Publikováno v: Journal of Ethnopharmacology

Ethnopharmacological relevance The subtribe Hyptidinae contains approximately 400 accepted species distributed in 19 genera (Hyptis, Eriope, Condea, Cantinoa, Mesosphaerum, Cyanocephalus, Hypenia, Hyptidendron, Oocephalus, Medusantha, Gymneia, Marsyp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7648d82747c7cec828132a1d0a2532c7
http://europepmc.org/articles/PMC7403033

Human cholesteryl ester transfer protein lacks lipopolysaccharide transfer activity, but worsens inflammation and sepsis outcomes in mice

Autor: Thomas Gautier, Kevin van Dongen, Émilie Charron, Stéphane Mandard, Valérie Deckert, Jean-Paul Pais de Barros, Hélène Choubley, Jérôme Labbé, Naig Le Guern, Jacques Grober, Alois Dusuel, Laurent Lagrost

Publikováno v: Journal of Lipid Research
Journal of Lipid Research, American Society for Biochemistry and Molecular Biology, 2020, pp.jlr.RA120000704. ⟨10.1194/jlr.RA120000704⟩
Journal of Lipid Research, Vol 62, Iss, Pp 100011-(2021)
Journal of Lipid Research, 2020, pp.jlr.RA120000704. ⟨10.1194/jlr.RA120000704⟩

International audience; Bacterial lipopolysaccharides (LPSs or endotoxins) can bind most proteins of the lipid transfer/LPS-binding protein (LT/LBP) family in host organisms. The LPS-bound LT/LBP proteins then trigger either an LPS-induced proinflamm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afd34527c453da1363375ba2659935a9
https://www.hal.inserm.fr/inserm-03052637

Impaired vascular function in sepsis-surviving rats mediated by oxidative stress and Rho-Kinase pathway

Autor: Maria Fernanda de Paula Werner, Karin Scheschowitsch, Jamil Assreuy, Luisa Mota da Silva, Priscila de Souza, José Eduardo da Silva-Santos, Karla L. Guarido

Publikováno v: Redox Biology, Vol 10, Iss C, Pp 140-147 (2016)
Redox Biology

We investigated long-lasting changes in endothelial and vascular function in adult rat survivors of severe sepsis induced by cecal ligation and puncture (CLP) model. For this, male Wistar rats (200–350 g) had their cecum punctured once (non-transfi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f683d0498c4a1ae5e694f26e46daa2d5
http://www.sciencedirect.com/science/article/pii/S2213231716301409