Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium

Autor: Robert F. Krueger, Teresa Nutile, Georg Homuth, Ina Giegling, Aarno Palotie, Katja Appel, Grant W. Montgomery, Elisabeth Widen, Jouke-Jan Hottenga, Beate St Pourcain, Caroline Hayward, Andrea Maschio, Andrew C. Heath, Narelle K. Hansell, Terho Lehtimäki, Wendy S. Slutske, Sarah E. Medland, Johan G. Eriksson, John M. Starr, Antonio Terracciano, Jonathan Marten, Olli T. Raitakari, Liisa Keltikangas-Järvinen, Igor Rudan, Kati Heinonen, Brenda W.J.H. Penninx, David J. Porteous, Klaasjan G. Ouwens, Barbara Franke, Jaakko Kaprio, Erik Pettersson, Jueri Allik, Ian J. Deary, Alessandra Minelli, Nicholas G. Martin, William G. Iacono, Yuri Milaneschi, Ilkka Seppälä, David M. Evans, Lina Zgaga, John P. Kemp, Alexander Teumer, Dorret I. Boomsma, Harry Campbell, Margaret J. Wright, Abraham A. Palmer, Jun Ding, Patrik K. E. Magnusson, Marleen H. M. de Moor, James F. Wilson, Anu Realo, Paul T. Costa, Scott D. Gordon, Jaime Derringer, Michel G. Nivard, Cornelia M. van Duijn, David C. Liewald, David Schlessinger, Marina Ciullo, Juho Wedenoja, Amy B. Hart, Laura J. Bierut, Angelina R. Sutin, Hamdi Mbarek, Alexander Viktorin, Stéphanie Martine van den Berg, Ozren Polasek, Harriet de Wit, Jari Lahti, Dan Rujescu, Nicholas J. Timpson, Matthias Nauck, Fabio Busonero, Iryna O. Fedko, Evelin Mihailov, Gonçalo R. Abecasis, John M. Hettema, Daniel E. Adkins, Hans J. Grabe, Richard A. Grucza, Luigi Ferrucci, Alejandro Arias Vasquez, Barbara E. Engelhardt, Laura Pulkki-Råback, Antti Latvala, Bettina Konte, Michelle Luciano, Robert Karlsson, Chiara Magri, Sita H. Vermeulen, Tõnu Esko, Arpana Agrawal, Matt McGue, Holly Trochet, Joost G. E. Janzing, Gail Davies, Toshiko Tanaka, Rossella Sorice, Timothy B. Bigdeli, Abdel Abdellaoui, Karin J. H. Verweij, Andres Metspalu, Nancy L. Pedersen, Anjali K. Henders, Matthew G. Kirkpatrick, Yong Qian, Lindsay K. Matteson, Annette M. Hartmann, George Davey Smith, Michael B. Miller, Najaf Amin, Pamela A. F. Madden, Richard J. Rose, Minyoung Lee, Eero Vuoksimaa, Katri Räikkönen, Markus Jokela, Jennifer E. Huffman, Carsten Oliver Schmidt, Jasper Wouda, Daniela Ruggiero

Publikováno v: Behavior Genetics
van den Berg, S M, de Moor, M H M, Verweij, C J H, Krueger, R F, Luciano, M, Vasquez, A A, Matteson, L K, Derringer, J, Esko, T, Amin, N, Gordon, S D, Hansell, N K, Hart, A B, Seppälä, I, Huffman, J E, Konte, B, Lahti, J, Miller, M, Nutile, T, Tanaka, T, Teumer, A, Viktorin, A, Wedenoja, J, Abdellaoui, A, Abecasis, G R, Adkins, D E, Agrawal, A, Allik, J, Appel, K, Bigdeli, T B, Busonero, F, Campbell, H, Costa, P T, Davey Smith, G, Davies, G, de Wit, H, Ding, J, Engelhardt, B E, Eriksson, J G, Fedko, I O, Ferrucci, L, Franke, B, Giegling, I, Grucza, R, Hartmann, A M, Heath, A C, Heinonen, K, Henders, A K, Homuth, G, Hottenga, J J, Iacono, W G, Janzing, J, Jokela, M, Karlsson, R, Kemp, J P, Kirkpatrick, M G, Latvala, A, Lehtimäki, T, Liewald, D C, Madden, P A F, Magri, C, Magnusson, P K E, Marten, J, Maschio, A, Mbarek, H, Medland, S E, Mihailov, E, Milaneschi, Y, Montgomery, G W, Nauck, M, Nivard, M G, Ouwens, K G, Palotie, A, Pettersson, E, Polasek, O, Qian, Y, Pulkki-Raback, L, Raitakari, O T, Realo, A, Rose, R J, Ruggiero, D, Schmidt, C O, Slutske, W S, Sorice, R, Starr, J M, St Pourcain, B, Sutin, A R, Timpson, N J, Trochet, H, Zgaga, L, Porteous, D, Minelli, A, Palmer, A A, Rujescu, D, Ciullo, M, Hayward, C, Rudan, I, Metspalu, A, Kaprio, J, Deary, I J, Räikkönen, K, Wilson, J F, Keltikangas-Järvinen, L, Bierut, L J, Hettema, J M, Grabe, H J, Penninx, B W J H, van Duijn, C M, Evans, D M, Schlessinger, D, Pedersen, N L, Terracciano, A, McGue, M, Martin, N G & Boomsma, D I 2016, ' Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium ', Behavior Genetics, vol. 46, no. 2, pp. 170-182 . https://doi.org/10.1007/s10519-015-9735-5
Behavior genetics, 46(2), 170-182. Springer New York
Behavior Genetics, 46, 2, pp. 170-82
Behavior genetics (2015). doi:10.1007/s10519-015-9735-5
info:cnr-pdr/source/autori:van Den Berg S.M.; de Moor M.H.M.; Verweij K.J.H.; Krueger R.F.; Luciano M.; Arias Vasquez A.; Matteson L.K.; Derringer J.; Esko T.; Amin N.; Gordon S.D.; Hansell N.K.; Hart A.B.; Seppala I.; Huffman J.E.; Konte B.; Lahti J.; Lee M.; Miller M.; Nutile T.; Tanaka T.; Teumer A.; Viktorin A.; Wedenoja J.; Abdellaoui A.; Abecasis G.R.; Adkins D.E.; Agrawal A.; Allik J.; Appel K.; Bigdeli T.B.; Busonero F.; Campbell H.; Costa P.T.; Smith G.D.; Davies G.; de Wit H.; Ding J.; Engelhardt B.E.; Eriksson J.G.; Fedko I.O.; Ferrucci L.; Franke B.; Giegling I.; Grucza R.; Hartmann A.M.; Heath A.C.; Heinonen K.; Henders A.K.; Homuth G.; Hottenga J.-J.; Iacono W.G.; Janzing J.; Jokela M.; Karlsson R.; Kemp J.P.; Kirkpatrick M.G.; Latvala A.; Lehtimaki T.; Liewald D.C.; Madden P.A.F.; Magri C.; Magnusson P.K.E.; Marten J.; Maschio A.; Mbarek H.; Medland S.E.; Mihailov E.; Milaneschi Y.; Montgomery G.W.; Nauck M.; Nivard M.G.; Ouwens K.G.; Palotie A.; Pettersson E.; Polasek O.; Qian Y.; Pulkki-Raback L.; Raitakari O.T.; Realo A.; Rose R.J.; Ruggiero D.; Schmidt C.O.; Slutske W.S.; Sorice R.; Starr J.M.; St Pourcain B.; Sutin A.R.; Timpson N.J.; Trochet H.; Vermeulen S.; Vuoksimaa E.; Widen E.; Wouda J.; Wright M.J.; Zgaga L.; Generation Scotland; Porteous D.; Minelli A.; Palmer A.A.; Rujescu D.; Ciullo M.; Hayward C.; Rudan I.; Metspalu A.; Kaprio J.; Deary I.J.; Raikkonen K.; Wilson J.F.; Keltikangas-Jarvinen L.; Bierut L.J.; Hettema J.M.; Grabe H.J.; Penninx B.W.J.H.; van Duijn C.M.; Evans D.M.; Schlessinger D.; Pedersen N.L.; Terracciano A.; McGue M.; Martin N.G.; Boomsma D.I./titolo:Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium/doi:10.1007%2Fs10519-015-9735-5/rivista:Behavior genetics/anno:2015/pagina_da:/pagina_a:/intervallo_pagine:/volume
van den Berg, S M, de Moor, M H M, Verweij, K J H, Krueger, R F, Luciano, M, Arias Vasquez, A, Matteson, L K, Derringer, J, Esko, T, Amin, N, Gordon, S D, Hansell, N K, Hart, A B, Seppälä, I, Huffman, J E, Konte, B, Lahti, J, Lee, M, Miller, M, Nutile, T, Tanaka, T, Teumer, A, Viktorin, A, Wedenoja, J, Abdellaoui, A, Abecasis, G R, Adkins, D E, Agrawal, A, Allik, J, Appel, K, Bigdeli, T B, Busonero, F, Campbell, H, Costa, P T, Smith, G D, Davies, G, de Wit, H, Ding, J, Engelhardt, B E, Eriksson, J G, Fedko, I O, Ferrucci, L, Franke, B, Giegling, I, Grucza, R, Kemp, J P, Medland, S E, St Pourcain, B, Timpson, N J, Evans, D M 2016, ' Meta-analysis of Genome-Wide Association Studies for Extraversion : Findings from the Genetics of Personality Consortium ', Behavior Genetics, vol. 46, no. 2, pp. 170-182 . https://doi.org/10.1007/s10519-015-9735-5
Behavior Genetics, 46, 170-182
Behavior genetics, 46(2), 170-182. Springer
Behavior Genetics, 46(2), 170-182. Springer US
Behavior Genetics, 46(2), 170-182. Springer
Behavior Genetics, 46, 170-82
van den Berg, S M, de Moor, M H M, Verweij, K J H, Krueger, R F, Luciano, M, Vasquez, A A, Matteson, L K, Derringer, J, Esko, T, Amin, N, Gordon, S D, Hansell, N K, Hart, A B, Seppala, I, Huffman, J E, Konte, B, Lahti, J, Lee, M, Miller, M, Nutile, T, Tanaka, T, Teumer, A, Viktorin, A, Wedenoja, J, Abdellaoui, A, Abecasis, G R, Adkins, D E, Agrawal, A, Allik, J, Appel, K, Bigdeli, T B, Busonero, F, Campbell, H, Costa, P T, Smith, G D, Davies, G, de Wit, H, Ding, J, Engelhardt, B E, Eriksson, J G, Fedko, I O, Ferrucci, L, Franke, B, Giegling, I, Grucza, R, Hartmann, A M, Heath, A C, Heinonen, K, Henders, A K, Homuth, G, Hottenga, J-J, Iacono, W G, Janzing, J, Jokela, M, Karlsson, R, Kemp, J P, Kirkpatrick, M G, Latvala, A, Lehtimaki, T, Liewald, D C, Madden, P A F, Magri, C, Magnusson, P K E, Marten, J, Maschio, A, Mbarek, H, Medland, S E, Mihailov, E, Milaneschi, Y, Montgomery, G W, Nauck, M, Nivard, M G, Ouwens, K G, Palotie, A, Pettersson, E, Polasek, O, Qian, Y, Pulkki-Raback, L, Raitakari, O T, Realo, A, Rose, R J, Ruggiero, D, Schmidt, C O, Slutske, W S, Sorice, R, Starr, J M, St Pourcain, B, Sutin, A R, Timpson, N J, Trochet, H, Vermeulen, S, Vuoksimaa, E, Widen, E, Wouda, J, Wright, M J, Zgaga, L, Porteous, D, Minelli, A, Palmer, A A, Rujescu, D, Ciullo, M, Hayward, C, Rudan, I, Metspalu, A, Kaprio, J, Deary, I J, Raikkonen, K, Wilson, J F, Keltikangas-Jarvinen, L, Bierut, L J, Hettema, J M, Grabe, H J, Penninx, B W J H, van Duijn, C M, Evans, D M, Schlessinger, D, Pedersen, N L, Terracciano, A, McGue, M, Martin, N G & Boomsma, D I 2016, ' Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium ', Behavior Genetics, vol. 46, no. 2, pp. 170-182 . https://doi.org/10.1007/s10519-015-9735-5
Behavior Genetics, 46(2), 170-182. Springer New York
van den Berg, S M, de Moor, M H M, Verweij, K J H, Krueger, R F, Luciano, M, Arias Vasquez, A, Matteson, L K, Derringer, J, Esko, T, Amin, N, Gordon, S D, Hansell, N K, Hart, A B, Seppälä, I, Huffman, J E, Konte, B, Lahti, J, Lee, M, Miller, M, Nutile, T, Tanaka, T, Teumer, A, Viktorin, A, Wedenoja, J, Abdellaoui, A, Abecasis, G R, Adkins, D E, Agrawal, A, Allik, J, Appel, K, Bigdeli, T B, Busonero, F, Campbell, H, Costa, P T, Smith, G D, Davies, G, de Wit, H, Ding, J, Engelhardt, B E, Eriksson, J G, Fedko, I O, Liewald, D C, Polasek, O, Starr, J M, Zgaga, L, Porteous, D, Hayward, C, Rudan, I & Deary, I J & Wilson, J F 2015, ' Meta-analysis of genome-wide association studies for extraversion : Findings from the Genetics of Personality Consortium ', Behavior Genetics . https://doi.org/10.1007/s10519-015-9735-5
van den Berg, S M, de Moor, M H M, Verweij, K J H, Krueger, R F, Luciano, M, Arias Vasquez, A, Matteson, L K, Derringer, J, Esko, T, Amin, D N, Gordon, S D, Hansell, N K, Hart, A B, Seppälä, I, Huffman, J E, Konte, B, Lahti, J, Lee, J M, Miller, M, Nutile, T, Tanaka, T, Teumer, A, Viktorin, A, Wedenoja, J, Abdellaoui, A, Abecasis, G R, Adkins, D E, Agrawal, A, Allik, J, Appel, K, Bigdeli, T B, Busonero, F, Campbell, H, Costa, P T, Smith, G D, Davies, G, De Wit, H, Ding, J Z, Engelhardt, B E, Eriksson, J G, Fedko, I O, Ferrucci, L, Franke, B, Giegling, I, Grucza, R, Hartmann, A M, Heath, A C, Heinonen, K, Henders, A K, Homuth, G, Hottenga, J J, Iacono, W G, Janzing, J, Jokela, M, Karlsson, R, Kemp, J P, Kirkpatrick, M G, Latvala, A, Lehtimäki, T, Liewald, D C, Madden, P A F, Magri, C, Magnusson, P K E, Marten, J, Maschio, A, Mbarek, H, Medland, S E, Mihailov, E, Milaneschi, Y, Montgomery, G W, Nauck, M, Nivard, M G, Ouwens, K G, Palotie, A, Pettersson, E, Polasek, O, Qian, Y-P, Pulkki-Råback, L, Raitakari, O T, Realo, A, Rose, R J, Ruggiero, D, Schmidt, C O, Slutske, W S, Sorice, R, Starr, J M, St Pourcain, B, Sutin, A R, Timpson, N J, Trochet, H, Vermeulen, S H, Vuoksimaa, E, Widen, E, Wouda, J, Wright, M J, Zgaga, L, Generation, S, Porteous, D J, Minelli, A, Palmer, L A, Rujescu, D, Ciullo, M, Hayward, C, Rudan, I, Metspalu, A, Kaprio, J, Deary, I J, Räikkönen, K, Wilson, J F, Keltikangas-Järvinen, L, Bierut, L J, Hettema, J M, Grabe, H-J, Penninx, B W J H, van Duijn, C M, Evans, D M, Schlessinger, D, Pedersen, N L, Terracciano, A, McGue, M, Martin, N G & Boomsma, D I 2016, ' Meta-analysis of Genome-Wide Association Studies for Extraversion : Findings from the Genetics of Personality Consortium ', Behavior Genetics, vol. 46, no. 2, pp. 170-182 . https://doi.org/10.1007/s10519-015-9735-5
Behavior Genetics, 46, 2, pp. 170-182

Extraversion is a relatively stable and heritable personality trait associated with numerous psychosocial, lifestyle and health outcomes. Despite its substantial heritability, no genetic variants have been detected in previous genome-wide association

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https://doi.org/10.1007/s10519-015-9735-5

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