Zobrazeno 1 - 10
of 198
pro vyhledávání: '"CLEMENTINA MANERA"'
Autor:
Maria Cristina Barbalace, Michela Freschi, Irene Rinaldi, Lorenzo Zallocco, Marco Malaguti, Clementina Manera, Gabriella Ortore, Mariachiara Zuccarini, Maurizio Ronci, Doretta Cuffaro, Marco Macchia, Silvana Hrelia, Laura Giusti, Maria Digiacomo, Cristina Angeloni
Publikováno v:
Antioxidants, Vol 13, Iss 9, p 1074 (2024)
Neuroinflammation is a critical aspect of various neurodegenerative diseases, such as Alzheimer’s and Parkinson’s diseases. This study investigates the anti-neuroinflammatory properties of oleocanthal and its oxidation product, oleocanthalic acid
Externí odkaz:
https://doaj.org/article/d9f544849f184aaabd43dac2b700cf24
Autor:
Beatrice Polini, Lorenzo Zallocco, Francesca Gado, Rebecca Ferrisi, Caterina Ricardi, Mariachiara Zuccarini, Vittoria Carnicelli, Clementina Manera, Maurizio Ronci, Antonio Lucacchini, Riccardo Zucchi, Laura Giusti, Grazia Chiellini
Publikováno v:
Cells, Vol 13, Iss 10, p 875 (2024)
Neurodegenerative diseases (NDDs) are progressive multifactorial disorders of the nervous system sharing common pathogenic features, including intracellular misfolded protein aggregation, mitochondrial deficit, and inflammation. Taking into considera
Externí odkaz:
https://doaj.org/article/e6f18c9d077e4bf597055d2cba86e5e3
Autor:
Andrea Caddeo, Marina Serra, Francesca Sedda, Andrea Bacci, Clementina Manera, Simona Rapposelli, Amedeo Columbano, Andrea Perra, Marta Anna Kowalik
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionSeveral lines of evidence suggest that the thyroid hormone signaling pathway is altered in patients with NAFLD and that pharmacological strategies to target the thyroid hormone/thyroid hormone nuclear receptor axis (TH/THR) in the liver m
Externí odkaz:
https://doaj.org/article/12be0e61ed8d46dc99ce7eb38fd5f8db
Autor:
Vito Antonio Baldassarro, Corinne Quadalti, Massimiliano Runfola, Clementina Manera, Simona Rapposelli, Laura Calzà
Publikováno v:
Pharmaceuticals, Vol 16, Iss 9, p 1207 (2023)
Oligodendrocytes and their precursors are the cells responsible for developmental myelination and myelin repair during adulthood. Their differentiation and maturation processes are regulated by a complex molecular machinery driven mainly by triiodoth
Externí odkaz:
https://doaj.org/article/398aa36f048c4a6289a0411069f6cdb8
Autor:
Rebecca Ferrisi, Francesca Gado, Beatrice Polini, Caterina Ricardi, Kawthar A. Mohamed, Lesley A. Stevenson, Gabriella Ortore, Simona Rapposelli, Giuseppe Saccomanni, Roger G. Pertwee, Robert B. Laprairie, Clementina Manera, Grazia Chiellini
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
It is well known that G protein–coupled receptors (GPCRs) assume multiple active states. Orthosteric ligands and/or allosteric modulators can preferentially stabilize specific conformations, giving rise to pathway-biased signaling. One of the most
Externí odkaz:
https://doaj.org/article/2b848fee1ff74619863f32ed3419e73b
Autor:
Daniela Gabbia, Sara Carpi, Samantha Sarcognato, Luana Cannella, Martina Colognesi, Michela Scaffidi, Beatrice Polini, Maria Digiacomo, Jasmine Esposito Salsano, Clementina Manera, Marco Macchia, Paola Nieri, Maria Carrara, Francesco Paolo Russo, Maria Guido, Sara De Martin
Publikováno v:
Frontiers in Nutrition, Vol 8 (2021)
Liver fibrosis, which is the outcome of wound-healing response to chronic liver damage, represents an unmet clinical need. This study evaluated the anti-fibrotic and anti-inflammatory effects of the polyphenol oleocanthal (OC) extracted from extra vi
Externí odkaz:
https://doaj.org/article/a97ed788a32f45a696e867d5596501c4
Autor:
Andrea Bacci, Francesca Corsi, Massimiliano Runfola, Simona Sestito, Ilaria Piano, Clementina Manera, Giuseppe Saccomanni, Claudia Gargini, Simona Rapposelli
Publikováno v:
Pharmaceuticals, Vol 15, Iss 6, p 688 (2022)
Overproduction of reactive oxygen species (ROS) and alterations in metallostasis are common and related hallmarks in several neurodegenerative diseases (NDDs). Nature-based derivatives always represent an attractive tool in MTDL drug design, especial
Externí odkaz:
https://doaj.org/article/01cccc83f1664f2b81c758eca66ebccf
Autor:
Francesca Gado, Rebecca Ferrisi, Sarah Di Somma, Fabiana Napolitano, Kawthar A. Mohamed, Lesley A. Stevenson, Simona Rapposelli, Giuseppe Saccomanni, Giuseppe Portella, Roger G. Pertwee, Robert B. Laprairie, Anna Maria Malfitano, Clementina Manera
Publikováno v:
Molecules, Vol 27, Iss 9, p 3019 (2022)
1,8-naphthyridine-3-carboxamide structures were previously identified as a promising scaffold from which to obtain CB2R agonists with anticancer and anti-inflammatory activity. This work describes the synthesis and functional characterization of new
Externí odkaz:
https://doaj.org/article/101b3cbd7b224d4aafd7636fae7db135
Autor:
Sara Carpi, Beatrice Polini, Clementina Manera, Maria Digiacomo, Jasmine Esposito Salsano, Marco Macchia, Egeria Scoditti, Paola Nieri
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Extra-virgin olive oil (EVOO) polyphenols contribute to Mediterranean diet health-promoting properties. One of the most abundant secoiridoid present in EVOO, Oleacein (OA), demonstrated anticancer activity against several tumors. Nevertheless, its ro
Externí odkaz:
https://doaj.org/article/943622cbfcb8477e9ca7d1c82b57b192
Autor:
Antonella Capozzi, Daniela Caissutti, Vincenzo Mattei, Francesca Gado, Stefano Martellucci, Agostina Longo, Serena Recalchi, Valeria Manganelli, Gloria Riitano, Tina Garofalo, Maurizio Sorice, Clementina Manera, Roberta Misasi
Publikováno v:
Molecules, Vol 27, Iss 1, p 64 (2021)
The endocannabinoid system (ECS) exerts immunosuppressive effects, which are mostly mediated by cannabinoid receptor 2 (CBR2), whose expression on leukocytes is higher than CBR1, mainly localized in the brain. Targeted CBR2 activation could limit inf
Externí odkaz:
https://doaj.org/article/4df138465d51425ab4b50f7f751fac86