Zobrazeno 1 - 10
of 115
pro vyhledávání: '"CLDN6"'
Publikováno v:
Cellular & Molecular Biology Letters, Vol 29, Iss 1, Pp 1-23 (2024)
Abstract Background Breast cancer (BC) ranks as the third most fatal malignant tumor worldwide, with a strong reliance on fatty acid metabolism. CLDN6, a candidate BC suppressor gene, was previously identified as a regulator of fatty acid biosynthesi
Externí odkaz:
https://doaj.org/article/4efe1a97eb60427aa817c80b7246b5c7
Autor:
Adrian Georg Simon, Su Ir Lyu, Mark Laible, Stefan Wöll, Özlem Türeci, Uğur Şahin, Hakan Alakus, Luca Fahrig, Thomas Zander, Reinhard Buettner, Christiane Josephine Bruns, Wolfgang Schroeder, Florian Gebauer, Alexander Quaas
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-16 (2023)
Abstract Background The prognosis of esophageal adenocarcinoma (EAC) and gastric adenocarcinoma (GAC) remains poor, and new therapeutic approaches are urgently needed. Claudin 6 (CLDN6) is an oncofetal antigen that is largely absent in healthy tissue
Externí odkaz:
https://doaj.org/article/955b99c2c4e6441e84f326d2f0b2a4bd
Autor:
Margaretha A. Skowron, Mara Kotthoff, Felix Bremmer, Katja Ruhnke, Fatma Parmaksiz, Annika Richter, Stefan Küffer, Kirsten Reuter-Jessen, Stella Pauls, Anja Stefanski, Philipp Ströbel, Kai Stühler, Daniel Nettersheim
Publikováno v:
Molecular Medicine, Vol 29, Iss 1, Pp 1-15 (2023)
Abstract Background Being the standard-of-care for four decades, cisplatin-based chemotherapy is highly efficient in treating germ cell tumors (GCT). However, often refractory patients present with a remaining (resistant) yolk-sac tumor (YST(-R)) com
Externí odkaz:
https://doaj.org/article/caf7ef9e806d4a1ba23d65a22dace983
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-17 (2023)
Abstract Background As a breast cancer suppressor gene, CLDN6 overexpression was found to inhibit breast cancer metastasis in our previous studies, but the specific mechanism remains unclear. This study aimed to clarify the role and mechanism of CLDN
Externí odkaz:
https://doaj.org/article/2f10e3f5224f40c1b1aa5cbf363abfcc
Autor:
Rosa A. van Amerongen, Sander Tuit, Anne K. Wouters, Marian van de Meent, Sterre L. Siekman, Miranda H. Meeuwsen, Tassilo L. A. Wachsmann, Dennis F. G. Remst, Renate S. Hagedoorn, Dirk M. van der Steen, Arnoud H. de Ru, Els M. E. Verdegaal, Peter A. van Veelen, J. H. Frederik Falkenburg, Mirjam H. M. Heemskerk
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Recurrent disease emerges in the majority of patients with ovarian cancer (OVCA). Adoptive T-cell therapies with T-cell receptors (TCRs) targeting tumor-associated antigens (TAAs) are considered promising solutions for less-immunogenic ‘cold’ ova
Externí odkaz:
https://doaj.org/article/97169a79cc174ce282d2474ef1bf87ec
Akademický článek
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Akademický článek
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K zobrazení výsledku je třeba se přihlásit.
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Autor:
Yiyang Jia, Yantong Guo, Qiu Jin, Huinan Qu, Da Qi, Peiye Song, Xiaoli Zhang, Xinqi Wang, Wenhong Xu, Yuan Dong, Yingying Liang, Chengshi Quan
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 39, Iss 1, Pp 1-15 (2020)
Abstract Background We have previously described CLDN6 as a tumor suppressor gene in breast cancer. Here, a new finding is that CLDN6 was upregulated under hypoxia, a commonly recognized factor that promotes tumor metastasis. In this study, we aim to
Externí odkaz:
https://doaj.org/article/9e67ef8801f24136bc02c80e99cdc5a7
Autor:
Peipei Gao, Ting Peng, Canhui Cao, Shitong Lin, Ping Wu, Xiaoyuan Huang, Juncheng Wei, Ling Xi, Qin Yang, Peng Wu
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
BackgroundThe claudin family is a group of transmembrane proteins related to tight junctions. While their involvement in cancer has been studied extensively, their relationship with the tumor immune microenvironment remains poorly understood. In this
Externí odkaz:
https://doaj.org/article/3b72d6162c33483e98878caef8702207
Autor:
Peiye Song, Yanru Li, Yuan Dong, Yingying Liang, Huinan Qu, Da Qi, Yan Lu, Xiangshu Jin, Yantong Guo, Yiyang Jia, Xinqi Wang, Wenhong Xu, Chengshi Quan
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-18 (2019)
Abstract Background Estrogen receptor β (ERβ) has been reported to play an anti-cancer role in breast cancer, but the regulatory mechanism by which ERβ exerts this effect is not clear. Claudin-6 (CLDN6), a tight junction protein, acts as a tumor s
Externí odkaz:
https://doaj.org/article/7239d92e4c0d4c9b91ad72ecfe0571f0