Zobrazeno 1 - 10
of 342
pro vyhledávání: '"CLAYTON H. HEATHCOCK"'
Autor:
Clayton H. Heathcock, Kazuhiko Takai
Publikováno v:
Journal of Synthetic Organic Chemistry, Japan. 68:3-18
Development of nucleophilic organometallic species plays an important role in organic synthesis, especially for construction of carbon skeletons. This account describes the following synthetic reactions with novel organometallic species: (1) Preparat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c69cc71bdb786e1060ad8133dc207b9d
https://doi.org/10.5059/yukigoseikyokaishi.68.3
https://doi.org/10.5059/yukigoseikyokaishi.68.3
Autor:
Alexander Melamed, Clayton H. Heathcock, Robert A. Wild, Qiang Wang, Carl E. Wagner, Craig R. Fairchild
Publikováno v:
Tetrahedron. 64:124-136
Several structural analogs that contain only part of the altohyrtin structure have been prepared and compared with synthetic altohyrtin C (2) for in vitro cytotoxicity against human colon (HCT116) and ovarian (A2780) cell lines. Whereas altohyrtin C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b28f07de43aec8ff8214993c23e56a25
https://doi.org/10.1016/j.tet.2007.10.065
https://doi.org/10.1016/j.tet.2007.10.065
Autor:
Grier A. Wallace, Clayton H. Heathcock, Michele M Claffey, Christopher J. Hayes, Mark L. McLaughlin, Jed L. Hubbs, J. R. Medina, Robert W. J. Scott, Gregory R. Ott
Publikováno v:
Journal of the American Chemical Society. 125:12844-12849
A multigram synthesis of the C29−C51 subunit of altohyrtin C (spongistatin 2) has been accomplished. Union of this intermediate with the C1−C28 fragment and further elaboration furnished the natural product. Completion of the C29−C51 subunit be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8610ac9837e397ce741b422b10b10430
https://doi.org/10.1021/ja030317+
https://doi.org/10.1021/ja030317+
Autor:
Clayton H. Heathcock, David Skyler
Publikováno v:
Journal of Natural Products. 65:1573-1581
The pyridoacridine natural products represent a large and growing class and serve here to illustrate the wealth of information that can be extracted by comparing natural products on the basis of structure and occurrence.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ccbcc0eda62250e07eac1da6235496a
https://doi.org/10.1021/np020016y
https://doi.org/10.1021/np020016y
Autor:
Jennifer D. Fell, Clayton H. Heathcock
Publikováno v:
The Journal of Organic Chemistry. 67:4742-4746
Two methods have been developed for efficient conversion of pregna-14,16-dien-20-ones into 14β-hydroxyandrost-15-en-17-ones. One procedure consists of treatment of the ring-D dienone successively with sodium borohydride and singlet oxygen. The react
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c936a55934ad5c312fc00ea90008e242
https://doi.org/10.1021/jo011175+
https://doi.org/10.1021/jo011175+
Autor:
Clayton H. Heathcock, Grier A. Wallace
Publikováno v:
The Journal of Organic Chemistry. 66:450-454
The scope of the 2-azadiene intramolecular Diels-Alder cyclization, previously employed for synthesis of the Daphniphyllum alkaloids, has been further investigated. Through a series of 1,5-diol cyclization precursors the substitution pattern of both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13b4672f9cba50dc56b2ae38f243015d
https://doi.org/10.1021/jo001145r
https://doi.org/10.1021/jo001145r
Autor:
Kana Yamamoto, Clayton H. Heathcock
Publikováno v:
Organic Letters. 2:1709-1712
Reactions of steroidal α,β-epoxy vinyl triflates in Pd-catalyzed reactions are described. Oxidative insertion of Pd0 into the C−O bond, giving vinylpalladium 12, is faster than formation of the π-a...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f506e49d1f181271ca15b2668b44924
https://doi.org/10.1021/ol000064e
https://doi.org/10.1021/ol000064e
Publikováno v:
The Journal of Organic Chemistry. 65:2642-2645
(+/-)-Aspidospermidine (1) has been synthesized from readily available methyl 3-ethyl-2-oxocylo-pentanecarboxylate (17) in 5.9% yield over 13 steps. The key step of the synthesis is an intramolecular cascade reaction that simultaneously forms the B,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb0d78d3b7435831862877243042e3d1
https://doi.org/10.1021/jo991599s
https://doi.org/10.1021/jo991599s
Autor:
Clayton H. Heathcock, Gregory R. Ott
Publikováno v:
Organic Letters. 1:1475-1478
[formula: see text] A method to construct the C44-C51 side chain of altohyrtin C has been developed and applied to a model aldehyde derived from D-glucose. The approach relies on a Wittig reaction to couple the side chain to an aldehyde and utilizes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de4b02431d38d358ff0582c900a888ed
https://doi.org/10.1021/ol990281j
https://doi.org/10.1021/ol990281j
Autor:
Shannon Chi, Clayton H. Heathcock
Publikováno v:
Organic Letters. 1:3-6
Preussomerins G and I (2 and 3) have been synthesized for the first time. The key reaction in the synthesis is a possibly biomimetic tautomerization reaction depicted in Scheme 3 and the foregoing graphic. The driving force for this interesting rearr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d94a3190127102d930ceffeea2d483ef
https://doi.org/10.1021/ol990020+
https://doi.org/10.1021/ol990020+