Zobrazeno 1 - 10
of 25
pro vyhledávání: '"CLAUDIA P. FIGUEIREDO"'
Autor:
Clara de O. Nogueira, Mariana Oliveira Lopes da Silva, Emanuelle V. de Lima, Raíssa Rilo Christoff, Daniel Gavino-Leopoldino, Felipe S. Lemos, Nicolas E. da Silva, Andrea T. Da Poian, Iranaia Assunção-Miranda, Claudia P. Figueiredo, Julia R. Clarke
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110178- (2024)
Summary: Zika virus (ZIKV) is a neurotropic flavivirus that can persist in several tissues. The late consequences of ZIKV persistence and whether new rounds of active replication can occur, remain unaddressed. Here, we investigated whether neonatally
Externí odkaz:
https://doaj.org/article/27b392db262740b08b1a5ba702918626
Autor:
Fabricia L. Fontes-Dantas, Gabriel G. Fernandes, Elisa G. Gutman, Emanuelle V. De Lima, Leticia S. Antonio, Mariana B. Hammerle, Hannah P. Mota-Araujo, Lilian C. Colodeti, Suzana M.B. Araújo, Gabrielle M. Froz, Talita N. da Silva, Larissa A. Duarte, Andreza L. Salvio, Karina L. Pires, Luciane A.A. Leon, Claudia Cristina F. Vasconcelos, Luciana Romão, Luiz Eduardo B. Savio, Jerson L. Silva, Robson da Costa, Julia R. Clarke, Andrea T. Da Poian, Soniza V. Alves-Leon, Giselle F. Passos, Claudia P. Figueiredo
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112189- (2023)
Summary: Cognitive dysfunction is often reported in patients with post-coronavirus disease 2019 (COVID-19) syndrome, but its underlying mechanisms are not completely understood. Evidence suggests that severe acute respiratory syndrome coronavirus 2 (
Externí odkaz:
https://doaj.org/article/fe134363e486421c960c5fd3b4c479bc
Autor:
Talita Nascimento da Silva, Emanuelle V. de Lima, Thaís Nogueira Barradas, Carla G. Testa, Paulo H.S. Picciani, Claudia P. Figueiredo, Flavia A. do Carmo, Julia R. Clarke
Publikováno v:
Materials Today Bio, Vol 18, Iss , Pp 100525- (2023)
Several human pathogens can cause long-lasting neurological damage. Despite the increasing clinical knowledge about these conditions, most still lack efficient therapeutic interventions. Gene therapy (GT) approaches comprise strategies to modify or a
Externí odkaz:
https://doaj.org/article/8fe72e0acfe140d6bd6891cc0b86b091
Autor:
Ana C. Vicente Santos, Francisca H. Guedes-da-Silva, Carlos H. Dumard, Vivian N. S. Ferreira, Igor P. S. da Costa, Ruana A. Machado, Fernanda G. Q. Barros-Aragão, Rômulo L. S. Neris, Júlio S. dos-Santos, Iranaia Assunção-Miranda, Claudia P. Figueiredo, André A. Dias, Andre M. O. Gomes, Herbert L. de Matos Guedes, Andrea C. Oliveira, Jerson L. Silva
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 11 (2021)
Zika virus (ZIKV) emerged as an important infectious disease agent in Brazil in 2016. Infection usually leads to mild symptoms, but severe congenital neurological disorders and Guillain-Barré syndrome have been reported following ZIKV exposure. Crea
Externí odkaz:
https://doaj.org/article/cfd630acb424434ca57acb58b694898d
Autor:
Claudia P. Figueiredo, Fernanda G. Q. Barros-Aragão, Rômulo L. S. Neris, Paula S. Frost, Carolina Soares, Isis N. O. Souza, Julianna D. Zeidler, Daniele C. Zamberlan, Virginia L. de Sousa, Amanda S. Souza, André Luis A. Guimarães, Maria Bellio, Jorge Marcondes de Souza, Soniza V. Alves-Leon, Gilda A. Neves, Heitor A. Paula-Neto, Newton G. Castro, Fernanda G. De Felice, Iranaia Assunção-Miranda, Julia R. Clarke, Andrea T. Da Poian, Sergio T. Ferreira
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Here, using ex-vivo human adult cortical tissue and a mouse model, the authors investigate the functional consequences of Zika virus (ZIKV) infection in the adult brain, and show that ZIKV causes synapse damage and altered brain function that impacts
Externí odkaz:
https://doaj.org/article/0bac999998154571acca058da9d921c8
Autor:
Helen M. Melo, Gisele da S. Seixas da Silva, Marcella Ramos Sant’Ana, Camila Vieira Ligo Teixeira, Julia R. Clarke, Vivian S. Miya Coreixas, Bruno C. de Melo, Juliana T.S. Fortuna, Leticia Forny-Germano, José Henrique Ledo, Maíra S. Oliveira, Claudia P. Figueiredo, Raphaelle Pardossi-Piquard, Frédéric Checler, José María Delgado-García, Agnès Gruart, Licio A. Velloso, Marcio L.F. Balthazar, Dennys E. Cintra, Sergio T. Ferreira, Fernanda G. De Felice
Publikováno v:
Cell Reports, Vol 30, Iss 7, Pp 2180-2194.e8 (2020)
Summary: Obesity has been associated with cognitive decline, atrophy of brain regions related to learning and memory, and higher risk of developing dementia. However, the molecular mechanisms underlying these neurological alterations are still largel
Externí odkaz:
https://doaj.org/article/a8705f38283e423d9640c717a5d7ee14
Autor:
Michelle P. Papa, Lana M. Meuren, Sharton V. A. Coelho, Carolina G. de Oliveira Lucas, Yasmin M. Mustafá, Flavio Lemos Matassoli, Paola P. Silveira, Paula S. Frost, Paula Pezzuto, Milene R. Ribeiro, Amilcar Tanuri, Mauricio L. Nogueira, Loraine Campanati, Marcelo T. Bozza, Heitor A. Paula Neto, Pedro M. Pimentel-Coelho, Claudia P. Figueiredo, Renato S. de Aguiar, Luciana B. de Arruda
Publikováno v:
Frontiers in Microbiology, Vol 8 (2017)
Zika virus (ZIKV) has been associated to central nervous system (CNS) harm, and virus was detected in the brain and cerebrospinal fluids of microcephaly and meningoencephalitis cases. However, the mechanism by which the virus reaches the CNS is uncle
Externí odkaz:
https://doaj.org/article/a7bf18c33a754b9189d2f87ed6c92534
Autor:
CLAUDIA P. FIGUEIREDO, NATALIA C. FERREIRA, GISELLE F. PASSOS, ROBSON DA COSTA, FERNANDA S. NEVES, CLARICE S.C. MACHADO, ALESSANDRA MASCARELLO, LOUISE D. CHIARADIA-DELATORRE, PATRÍCIA D. NEUENFELDT, RICARDO J. NUNES, YRAIMA CORDEIRO
Publikováno v:
Anais da Academia Brasileira de Ciências, Vol 87, Iss 2 suppl, Pp 1421-1434 (2015)
An altered form of the cellular prion protein, the PrPScor PrPRes, is implicated in the occurrence of the still untreatable transmissible spongiform encephalopathies. We have previously synthesized and characterized aromatic compounds that inhibit pr
Externí odkaz:
https://doaj.org/article/7c9d0eadc0b24f0895791b4cc5cc305c
Autor:
RICARDO A.L. DE SOUSA, YASMIN S. TORRES, CLAUDIA P. FIGUEIREDO, GISELLE F. PASSOS, JULIA R. CLARKE
Publikováno v:
Anais da Academia Brasileira de Ciências, Iss 0 (2017)
ABSTRACT Gestational diabetes mellitus (GD) is a form of insulin resistance triggered during the second/third trimesters of pregnancy in previously normoglycemic women. It is currently estimated that 10% of all pregnancies in the United States show t
Externí odkaz:
https://doaj.org/article/94c0a748c7a54a949fe4293f12342921
Autor:
Isis N. O. Souza, Fernanda G. Q. Barros-Aragão, Paula S. Frost, Claudia P. Figueiredo, Julia R. Clarke
Publikováno v:
Pharmaceuticals, Vol 12, Iss 2, p 60 (2019)
Zika virus (ZIKV) infection was historically considered a disease with mild symptoms and no major consequences to human health. However, several long-term, late onset, and chronic neurological complications, both in congenitally-exposed babies and in
Externí odkaz:
https://doaj.org/article/0c980daaca1542dda9dec2b7cee1b71f