Targeted demethylation and activation of NLRC5 augment cancer immunogenicity through MHC class I.

Autor: Sun X; Department of Immunology, Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, Japan., Watanabe T; Department of Immunology, Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, Japan., Oda Y; Department of Cancer Pathology, Graduate School of Medicine, Hokkaido University, Hokkaido, Sapporo 060-8638, Japan., Shen W; Division of Functional Immunology, Section of Disease Control, Institute for Genetic Medicine, Hokkaido University, Sapporo 060-8638, Japan., Ahmad A; Department of Immunology, Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, Japan., Ouda R; Department of Immunology, Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, Japan., de Figueiredo P; Department of Microbial Pathogenesis and Immunology, Texas A&M Health Science Center, Bryan, TX 77807.; Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, MO 65211.; Christopher S. Bond Life Sciences Center, University of Missouri, Columbia, MO 65211.; Department of Veterinary Pathobiology, University of Missouri School of Veterinary Medicine, Columbia, MO 65211., Kitamura H; Division of Functional Immunology, Section of Disease Control, Institute for Genetic Medicine, Hokkaido University, Sapporo 060-8638, Japan.; Department of Biomedical Engineering, Faculty of Science and Engineering, Toyo University, Kawagoe 350-8585, Japan., Tanaka S; Department of Cancer Pathology, Graduate School of Medicine, Hokkaido University, Hokkaido, Sapporo 060-8638, Japan.; Institute for Chemical Reaction Design and Discovery, Hokkaido University, Sapporo 001-0021, Japan., Kobayashi KS; Department of Immunology, Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, Japan.; Department of Microbial Pathogenesis and Immunology, Texas A&M Health Science Center, Bryan, TX 77807.; Institute for Vaccine Research and Development, Hokkaido University, Sapporo 060-8638, Japan.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Feb 06; Vol. 121 (6), pp. e2310821121. Date of Electronic Publication: 2024 Feb 01.

MR1 presents vitamin B6-related compounds for recognition by MR1-reactive T cells.

Autor: McInerney MP; Department of Biochemistry and Molecular Biology and Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia., Awad W; Department of Biochemistry and Molecular Biology and Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia., Souter MNT; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC 3052, Australia., Kang Y; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC 3052, Australia., Wang CJH; Department of Biochemistry and Molecular Biology and Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia., Chan Yew Poa K; Department of Biochemistry and Molecular Biology and Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia., Abdelaal MR; Department of Biochemistry and Molecular Biology and Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia., Le NH; Department of Biochemistry and Molecular Biology and Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia., Shepherd CM; Department of Biochemistry and Molecular Biology and Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia., McNeice C; Department of Biochemistry and Molecular Biology and Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia., Meehan LJ; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC 3052, Australia., Nelson AG; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC 3052, Australia., Raynes JM; Department of Biochemistry and Molecular Biology and Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia., Mak JYW; Centre for Chemistry and Drug Discovery and Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia., McCluskey J; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC 3052, Australia., Chen Z; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, VIC 3052, Australia., Ang CS; Mass Spectrometry and Proteomics Facility, Bio21 Institute, The University of Melbourne, Parkville, VIC 3052, Australia., Fairlie DP; Centre for Chemistry and Drug Discovery and Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia., Le Nours J; Department of Biochemistry and Molecular Biology and Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia., Illing PT; Department of Biochemistry and Molecular Biology and Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia., Rossjohn J; Department of Biochemistry and Molecular Biology and Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.; Institute of Infection and Immunity, Cardiff University, School of Medicine, Heath Park, Cardiff CF10 3AT, United Kingdom., Purcell AW; Department of Biochemistry and Molecular Biology and Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Dec 03; Vol. 121 (49), pp. e2414792121. Date of Electronic Publication: 2024 Nov 26.

Beyond FAScinating: advances in diagnosis and management of autoimmune lymphoproliferative syndrome and activated PI3 kinase δ syndrome.

Autor: Rao VK; National Institutes of Health (NIH), Bethesda, MD., Pittaluga S; National Institutes of Health (NIH), Bethesda, MD., Uzel G; National Institutes of Health (NIH), Bethesda, MD.

Publikováno v: Hematology. American Society of Hematology. Education Program [Hematology Am Soc Hematol Educ Program] 2024 Dec 06; Vol. 2024 (1), pp. 126-136.

ATP-competitive inhibitors of PI3K enzymes demonstrate an isoform selective dual action by controlling membrane binding.

Autor: Gong GQ; Department of Molecular Medicine, The University of Auckland, Auckland, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand., Masson GR; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB20QH, U.K., Lee WJ; Department of Molecular Medicine, The University of Auckland, Auckland, New Zealand., Dickson JMJ; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand.; School of Biological Sciences, The University of Auckland, Auckland, New Zealand., Kendall JD; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand.; Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand., Rathinaswamy MK; Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada V8W 2Y2., Buchanan CM; Department of Molecular Medicine, The University of Auckland, Auckland, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand., Middleditch M; School of Biological Sciences, The University of Auckland, Auckland, New Zealand., Owen BM; Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand., Spicer JA; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand.; Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand., Rewcastle GW; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand.; Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand., Denny WA; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand.; Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand., Burke JE; Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada V8W 2Y2., Shepherd PR; Department of Molecular Medicine, The University of Auckland, Auckland, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand.; Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand., Williams RL; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB20QH, U.K., Flanagan JU; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand.; Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand.; Department of Pharmacology and Clinical Pharmacology, The University of Auckland, Auckland, New Zealand.

Publikováno v: The Biochemical journal [Biochem J] 2024 Dec 04; Vol. 481 (23), pp. 1787-1802.

The neonatal Fc receptor is a cellular receptor for human astrovirus.

Autor: Ingle H; Division of Infectious Diseases, Department of Medicine, Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA., Molleston JM; Division of Infectious Diseases, Department of Medicine, Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA.; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Washington University School of Medicine, St Louis, MO, USA., Hall PD; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA., Bui D; Division of Infectious Diseases, Department of Medicine, Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA., Wang L; Division of Infectious Diseases, Department of Medicine, Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA., Bhatt KD; Division of Infectious Diseases, Department of Medicine, Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA., Foster L; Division of Infectious Diseases, Department of Medicine, Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA., Antia A; Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA., Ding S; Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA., Lee S; Department of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University, Providence, RI, USA., Fremont DH; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.; Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA.; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, MO, USA., Baldridge MT; Division of Infectious Diseases, Department of Medicine, Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA. mbaldridge@wustl.edu.; Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA. mbaldridge@wustl.edu.

Publikováno v: Nature microbiology [Nat Microbiol] 2024 Dec; Vol. 9 (12), pp. 3321-3331. Date of Electronic Publication: 2024 Nov 22.