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Cross-Ancestry Investigation of Venous Thromboembolism Genomic Predictors

Autor: Thibord, Florian, Klarin, Derek, Brody, Jennifer A., Chen, Ming-Huei, Levin, Michael G., Chasman, Daniel I., Goode, Ellen L., Hveem, Kristian, Teder-Laving, Maris, Martinez-Perez, Angel, Aïssi, Dylan, Daian-Bacq, Delphine, Ito, Kaoru, Natarajan, Pradeep, Lutsey, Pamela L., Nadkarni, Girish N., de Vries, Paul S., Cuellar-Partida, Gabriel, Wolford, Brooke N., Pattee, Jack W., Kooperberg, Charles, Braekkan, Sigrid K., Li-Gao, Ruifang, Saut, Noemie, Sept, Corriene, Germain, Marine, Judy, Renae L., Wiggins, Kerri L., Ko, Darae, O’Donnell, Christopher J., Taylor, Kent D., Giulianini, Franco, De Andrade, Mariza, Nøst, Therese H., Boland, Anne, Empana, Jean-Philippe, Koyama, Satoshi, Gilliland, Thomas, Do, Ron, Huffman, Jennifer E., Wang, Xin, Zhou, Wei, Manuel Soria, Jose, Carlos Souto, Juan, Pankratz, Nathan, Haessler, Jeffery, Hindberg, Kristian, Rosendaal, Frits R., Turman, Constance, Olaso, Robert, Kember, Rachel L., Bartz, Traci M., Lynch, Julie A., Heckbert, Susan R., Armasu, Sebastian M., Brumpton, Ben, Smadja, David M., Jouven, Xavier, Komuro, Issei, Clapham, Katharine R., Loos, Ruth J.F., Willer, Cristen J., Sabater-Lleal, Maria, Pankow, James S., Reiner, Alexander P., Morelli, Vania M., Ridker, Paul M, Vlieg, Astrid van Hylckama, Deleuze, Jean-François, Kraft, Peter, Rader, Daniel J., Min Lee, Kyung, Psaty, Bruce M., Heidi Skogholt, Anne, Emmerich, Joseph, Suchon, Pierre, Rich, Stephen S., Vy, Ha My T., Tang, Weihong, Jackson, Rebecca D., Hansen, John-Bjarne, Morange, Pierre-Emmanuel, Kabrhel, Christopher, Trégouët, David-Alexandre, Damrauer, Scott M., Johnson, Andrew D., Smith, Nicholas L.

Publikováno v: Circulation (Ovid); October 2022, Vol. 146 Issue: 16 p1225-1242, 18p

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The W100 pocket on HIV-1 gp120 penetrated by b12 is not a target for other CD4bs monoclonal antibodies

Autor: Dueñas-Decamp Maria J, O'Connell Olivia J, Corti Davide, Zolla-Pazner Susan, Clapham Paul R

Publikováno v: Retrovirology, Vol 9, Iss 1, p 9 (2012)

Abstract Background The conserved CD4 binding site (CD4bs) on HIV-1 gp120 is a major target for vaccines. It is a priority to determine sites and structures within the CD4bs that are important for inclusion in vaccines. We studied a gp120 pocket pene

Externí odkaz: https://doaj.org/article/99d2d90bc0f240bb94e3e4e965a8fb46

Modulation of HIV-1 macrophage-tropism among R5 envelopes occurs before detection of neutralizing antibodies

Autor: McKnight Áine, Aasa-Chapman Marlén MI, Richards Kathryn H, Clapham Paul R

Publikováno v: Retrovirology, Vol 7, Iss 1, p 48 (2010)

Abstract HIV-1 R5 viruses vary widely in their capacity to infect primary macrophages. R5 macrophage-tropism is associated with an increased envelope:CD4 affinity that partly results from an increased exposure of CD4 contact residues on gp120 and all

Externí odkaz: https://doaj.org/article/72c77121e22d4fbf80c437fe7840b989