Elucidating the molecular genetic basis of cluster headache: delineation of the genetic architecture by exome sequencing

Autor: L Southgate, S Scollen, W He, A Moss, MA Simpson, B Zhang, L Xi, T Schlitt, ME Weale, CL Hyde, JC Stephens, C Sjöstrand, MB Russell, M Leone, SL John, RC Trembath

Publikováno v: The Journal of Headache and Pain. 1:P34

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f2a6d3a456ebe5e0d607694dab4723d
https://doi.org/10.1186/1129-2377-1-s1-p34

Genome-wide pharmacogenetics of anti-drug antibody response to bococizumab highlights key residues in HLA DRB1 and DQB1.

Autor: Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA. dchasman@research.bwh.harvard.edu.; Harvard Medical School, Boston, MA, USA. dchasman@research.bwh.harvard.edu., Hyde CL; Pfizer Inc., 1 Portland Street, Cambridge, MA, USA., Giulianini F; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA., Danning RD; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA., Wang EQ; Pfizer Inc., New York, NY, USA., Hickling T; Pfizer Inc., 1 Portland Street, Cambridge, MA, USA., Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Loomis AK; Pfizer Inc., 1 Portland Street, Cambridge, MA, USA.

Publikováno v: Scientific reports [Sci Rep] 2022 Mar 11; Vol. 12 (1), pp. 4266. Date of Electronic Publication: 2022 Mar 11.

The genomics of heart failure: design and rationale of the HERMES consortium.

Autor: Lumbers RT; Institute of Health Informatics, University College London, Gower St, London, WC1E 7HB, UK.; Health Data Research UK London, University College London, London, UK.; BHF Research Accelerator, University College London, London, UK., Shah S; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.; Institute of Cardiovascular Science, University College London, London, UK., Lin H; Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.; National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA., Czuba T; Department of Cardiology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden., Henry A; Institute of Health Informatics, University College London, Gower St, London, WC1E 7HB, UK.; Institute of Cardiovascular Science, University College London, London, UK., Swerdlow DI; Institute of Cardiovascular Science, University College London, London, UK.; Department of Medicine, Imperial College London, London, UK., Mälarstig A; Pfizer Worldwide Research & Development, Cambridge, MA, USA.; Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institute, Stockholm, Sweden., Andersson C; National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.; Department of Cardiology, Herlev Gentofte Hospital, Herlev, Denmark., Verweij N; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Holmes MV; Medical Research Council Population Health Research Unit at the University of Oxford, Oxford, UK.; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, Big Data Institute, University of Oxford, Oxford, UK.; National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospital, Oxford, UK., Ärnlöv J; Department of Neurobiology, Care Sciences and Society/Section of Family Medicine and Primary Care, Karolinska Institutet, Stockholm, Sweden.; School of Health and Social Sciences, Dalarna University, Falun, Sweden., Svensson P; Department of Clinical Science and Education, Karolinska Institutet, Södersjukhuset, Stockholm, Sweden.; Department of Cardiology, Södersjukhuset, Stockholm, Sweden., Hemingway H; Institute of Health Informatics, University College London, Gower St, London, WC1E 7HB, UK.; Health Data Research UK London, University College London, London, UK.; The National Institute for Health Research, University College London Hospitals Biomedical Research Centre, University College London, London, UK., Sallah N; Institute of Health Informatics, University College London, Gower St, London, WC1E 7HB, UK.; Health Data Research UK London, University College London, London, UK.; UCL Genetics Institute, University College London, London, UK., Almgren P; Department of Clinical Sciences, Lund University, Malmö, Sweden., Aragam KG; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Asselin G; Montreal Heart Institute, Montreal, Quebec, Canada., Backman JD; Regeneron Genetics Center, Tarrytown, NY, USA., Biggs ML; Department of Biostatistics, University of Washington, Seattle, WA, USA.; Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, WA, USA., Bloom HL; Division of Cardiology, Department of Medicine, Emory University Medical Center, Atlanta, GA, USA., Boersma E; Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Brandimarto J; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Brown MR; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Brunner-La Rocca HP; Maastricht University Medical Center, Maastricht, The Netherlands., Carey DJ; Department of Molecular and Functional Genomics, Geisinger, Danville, PA, USA., Chaffin MD; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Chazara O; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Chen X; Pfizer Worldwide Research & Development, Cambridge, MA, USA., Chen X; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Chung JH; Regeneron Genetics Center, Tarrytown, NY, USA., Chutkow W; Novartis Institutes for Biomedical Research, Cambridge, MA, USA., Cleland JGF; Robertson Centre for Biostatistics & Glasgow Clinical Trials Unit, Institute of Health and Wellbeing, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK.; National Heart and Lung Institute, Imperial College, London, UK., Cook JP; Department of Biostatistics, University of Liverpool, Liverpool, UK., de Denus S; Montreal Heart Institute, Montreal, Quebec, Canada.; Faculty of Pharmacy, Université de Montréal, Montreal, Quebec, Canada., Dehghan A; Department of Epidemiology and Biostatistics, Imperial College London, St Mary's Campus, London, UK.; MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, Imperial College London, St Mary's Campus, London, UK., Delgado GE; Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Heidelberg, Germany., Denaxas S; Institute of Health Informatics, University College London, Gower St, London, WC1E 7HB, UK.; Health Data Research UK London, University College London, London, UK.; The National Institute for Health Research, University College London Hospitals Biomedical Research Centre, University College London, London, UK.; The Alan Turing Institute, British Library, London, UK., Doney AS; Division of Molecular and Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK., Dörr M; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany., Dudley SC; Cardiovascular Division, Department of Medicine, University of Minnesota, Minneapolis, MN, USA., Engström G; Department of Clinical Sciences, Lund University, Malmö, Sweden., Esko T; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Fatemifar G; Institute of Health Informatics, University College London, Gower St, London, WC1E 7HB, UK.; Health Data Research UK London, University College London, London, UK., Felix SB; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany., Finan C; Institute of Cardiovascular Science, University College London, London, UK., Ford I; Robertson Centre for Biostatistics & Glasgow Clinical Trials Unit, Institute of Health and Wellbeing, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK., Fougerousse F; Translational and Clinical Research, Servier Cardiovascular Center for Therapeutic Innovation, Suresnes, France., Fouodjio R; Montreal Heart Institute, Montreal, Quebec, Canada., Ghanbari M; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands., Ghasemi S; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Giedraitis V; Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden., Giulianini F; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA., Gottdiener JS; Department of Medicine, Division of Cardiology, University of Maryland School of Medicine, Baltimore, MD, USA., Gross S; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany., Guðbjartsson DF; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland., Gui H; Center for Individualized and Genomic Medicine Research, Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, USA., Gutmann R; Division of Cardiovascular Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA., Haggerty CM; Department of Translational Data Science and Informatics, Geisinger, Danville, PA, USA., van der Harst P; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, The Netherlands., Hedman ÅK; Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institute, Stockholm, Sweden., Helgadottir A; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Hillege H; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Hyde CL; Pfizer Worldwide Research & Development, Cambridge, MA, USA., Jacob J; Novartis Institutes for Biomedical Research, Cambridge, MA, USA., Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.; Netherlands Heart Institute, Utrecht, The Netherlands., Kamanu F; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Kardys I; Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Kavousi M; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands., Khaw KT; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Kleber ME; Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Heidelberg, Germany., Køber L; Department of Cardiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark., Koekemoer A; Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Kraus B; Duke Molecular Physiology Institute, Durham, NC, USA., Kuchenbaecker K; UCL Genetics Institute, University College London, London, UK.; Division of Psychiatry, University College of London, London, UK., Langenberg C; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK., Lind L; Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Lindgren CM; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., London B; Division of Cardiovascular Medicine and Abboud Cardiovascular Research Center, University of Iowa, Iowa City, IA, USA., Lotta LA; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK., Lovering RC; Institute of Cardiovascular Science, University College London, London, UK., Luan J; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK., Magnusson P; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Mahajan A; Genentech Inc., San Francisco, CA, USA., Mann D; Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Margulies KB; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Marston NA; TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., März W; Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Heidelberg, Germany.; Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim, Germany.; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria., McMurray JJV; BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, UK., Melander O; Department of Internal Medicine, Clinical Sciences, Lund University and Skåne University Hospital, Malmö, Sweden., Melloni G; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Mordi IR; Division of Molecular and Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK., Morley MP; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Morris AD; Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Morris AP; Department of Biostatistics, University of Liverpool, Liverpool, UK.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Morrison AC; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Nagle MW; Pfizer Worldwide Research & Development, Cambridge, MA, USA., Nelson CP; Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Newton-Cheh C; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA., Niessner A; Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria., Niiranen T; Finnish Institute for Health and Welfare, Helsinki, Finland.; Department of Medicine, Turku University Hospital and University of Turku, Turku, Finland., Nowak C; Department of Neurobiology, Care Sciences and Society/Section of Family Medicine and Primary Care, Karolinska Institutet, Stockholm, Sweden., O'Donoghue ML; TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Owens AT; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Palmer CNA; Division of Molecular and Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK., Paré G; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada., Perola M; National Institute for Health and Welfare, Helsinki, Finland., Perreault LL; Montreal Heart Institute, Montreal, Quebec, Canada., Portilla-Fernandez E; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.; Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands., Psaty BM; Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle, WA, USA., Rice KM; Department of Biostatistics, University of Washington, Seattle, WA, USA., Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Romaine SPR; Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Roselli C; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Ruff CT; TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Sabatine MS; TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Salo P; Finnish Institute for Health and Welfare, Helsinki, Finland., Salomaa V; Finnish Institute for Health and Welfare, Helsinki, Finland., van Setten J; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands., Shalaby AA; Division of Cardiology, Department of Medicine, University of Pittsburgh Medical Center and VA Pittsburgh HCS, Pittsburgh, PA, USA., Smelser DT; Department of Molecular and Functional Genomics, Geisinger, Danville, PA, USA., Smith NL; Kaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Veterans Affairs Office of Research and Development, Seattle Epidemiologic Research and Information Center, Seattle, WA, USA., Stefansson K; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Faculty of Medicine, Department of Medicine, University of Iceland, Reykjavik, Iceland., Stender S; Department of Clinical Biochemistry, Copenhagen University Hospital, Herlev and Gentofte, Denmark., Stott DJ; Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Sveinbjörnsson G; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Tammesoo ML; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Tardif JC; Montreal Heart Institute, Montreal, Quebec, Canada.; Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada., Taylor KD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Teder-Laving M; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Teumer A; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Thorgeirsson G; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Faculty of Medicine, Department of Medicine, University of Iceland, Reykjavik, Iceland., Thorsteinsdottir U; deCODE genetics/Amgen Inc., Reykjavik, Iceland.; Faculty of Medicine, Department of Medicine, University of Iceland, Reykjavik, Iceland., Torp-Pedersen C; Department of Epidemiology and Biostatistics, Aalborg University Hospital, Aalborg, Denmark.; Department of Health, Science and Technology, Aalborg University Hospital, Aalborg, Denmark.; Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark., Trompet S; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.; Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands., Tuckwell D; Novartis Institutes for Biomedical Research, Cambridge, MA, USA., Tyl B; Translational and Clinical Research, Servier Cardiovascular Center for Therapeutic Innovation, Suresnes, France., Uitterlinden AG; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Vaura F; Finnish Institute for Health and Welfare, Helsinki, Finland.; Department of Clinical Medicine, University of Turku, Turku, Finland., Veluchamy A; Division of Molecular and Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK., Visscher PM; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia., Völker U; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany., Voors AA; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Wang X; Novartis Institutes for Biomedical Research, Cambridge, MA, USA., Wareham NJ; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK., Weeke PE; Department of Cardiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark., Weiss R; Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University Medical Center, Columbus, OH, USA., White HD; Green Lane Cardiovascular Service, Auckland City Hospital, Auckland, New Zealand., Wiggins KL; Department of Medicine, University of Washington, Seattle, WA, USA., Xing H; Novartis Institutes for Biomedical Research, Cambridge, MA, USA., Yang J; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia., Yang Y; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Yerges-Armstrong LM; Human Genetics, GlaxoSmithKline, Collegeville, PA, USA., Yu B; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Zannad F; CHU de Nancy, Inserm and INI-CRCT (F-CRIN), Institut Lorrain du Coeur et des Vaisseaux, Université de Lorraine, Nancy, France., Zhao F; Novartis Institutes for Biomedical Research, Cambridge, MA, USA., Wilk JB; Pfizer Worldwide Research & Development, Cambridge, MA, USA., Holm H; deCODE genetics/Amgen Inc., Reykjavik, Iceland., Sattar N; BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, UK., Lubitz SA; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiac Arrhythmia Service and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Lanfear DE; Center for Individualized and Genomic Medicine Research, Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, USA.; Heart and Vascular Institute, Henry Ford Hospital, Detroit, MI, USA., Shah S; Duke Molecular Physiology Institute, Durham, NC, USA.; Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC, USA.; Duke Clinical Research Institute, Durham, NC, USA., Dunn ME; Regeneron Pharmaceuticals, Cardiovascular Research, Tarrytown, NY, USA., Wells QS; Division of Cardiovascular Medicine and the Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University, Nashville, TN, USA., Asselbergs FW; Health Data Research UK London, University College London, London, UK.; BHF Research Accelerator, University College London, London, UK.; Institute of Cardiovascular Science, University College London, London, UK.; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands., Hingorani AD; BHF Research Accelerator, University College London, London, UK.; Institute of Cardiovascular Science, University College London, London, UK., Dubé MP; Montreal Heart Institute, Montreal, Quebec, Canada.; Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada., Samani NJ; Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Lang CC; Division of Molecular and Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK., Cappola TP; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Ellinor PT; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiac Arrhythmia Service and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Vasan RS; National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.; Sections of Cardiology, Preventive Medicine and Epidemiology, Department of Medicine, Boston University Schools of Medicine and Public Health, Boston, MA, USA., Smith JG; Department of Cardiology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden.; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Wallenberg Center for Molecular Medicine and Lund University Diabetes Center, Lund University, Lund, Sweden.; The Wallenberg Laboratory/Department of Molecular and Clinical Medicine, Institute of Medicine, Gothenburg University and the Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden.

Publikováno v: ESC heart failure [ESC Heart Fail] 2021 Dec; Vol. 8 (6), pp. 5531-5541. Date of Electronic Publication: 2021 Sep 03.

Self-report data as a tool for subtype identification in genetically-defined Parkinson's Disease.

Autor: Winslow AR; Human Genetics and Computational Biomedicine, Pfizer Worldwide Research and Development, 1 Portland Street, Cambridge, MA, 02139, USA. awinslow@upenn.edu.; Orphan Disease Center, University of Pennsylvania, 125 S. 31st St., Philadelphia, PA, 19104, USA. awinslow@upenn.edu., Hyde CL; Early Clinical Development, Pfizer Worldwide Research and Development, 558 Eastern Point Rd., Groton, CT, 06340, USA., Wilk JB; Human Genetics and Computational Biomedicine, Pfizer Worldwide Research and Development, 1 Portland Street, Cambridge, MA, 02139, USA., Eriksson N; 23andMe Inc., 899W. Evelyn Avenue, Mountain View, CA, 94041, USA., Cannon P; 23andMe Inc., 899W. Evelyn Avenue, Mountain View, CA, 94041, USA., Miller MR; Human Genetics and Computational Target Validation, Pfizer Worldwide Research and Development, 1 Portland Street, Cambirdge, MA, 02139, USA., Hirst WD; Neuroscience, Pfizer Worldwide Research and Development, 1 Portland Street, Cambridge, MA, 02139, USA.; Parkinson's Disease and Movement Disorders Research, Biogen Research and Early Development, 115 Broadway, Cambridge, MA, 02142, USA.

Publikováno v: Scientific reports [Sci Rep] 2018 Aug 28; Vol. 8 (1), pp. 12992. Date of Electronic Publication: 2018 Aug 28.

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression.

Autor: Wray NR; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia. naomi.wray@uq.edu.au.; Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia. naomi.wray@uq.edu.au., Ripke S; Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Department of Psychiatry and Psychotherapy, Universitätsmedizin Berlin Campus Charité Mitte, Berlin, Germany., Mattheisen M; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; iSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, Denmark.; iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden., Trzaskowski M; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., Byrne EM; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., Abdellaoui A; Department of Biological Psychology and EMGO+ Institute for Health and Care Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Adams MJ; Division of Psychiatry, University of Edinburgh, Edinburgh, UK., Agerbo E; iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Centre for Integrated Register-Based Research, Aarhus University, Aarhus, Denmark.; National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark., Air TM; Discipline of Psychiatry, University of Adelaide, Adelaide, South Australia, Australia., Andlauer TMF; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Bacanu SA; Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA., Bækvad-Hansen M; iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark., Beekman AFT; Department of Psychiatry, Vrije Universiteit Medical Center and GGZ inGeest, Amsterdam, The Netherlands., Bigdeli TB; Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.; Virginia Institute for Psychiatric and Behavior Genetics, Richmond, VA, USA., Binder EB; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA., Blackwood DRH; Division of Psychiatry, University of Edinburgh, Edinburgh, UK., Bryois J; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Buttenschøn HN; iSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, Denmark.; iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Department of Clinical Medicine, Translational Neuropsychiatry Unit, Aarhus University, Aarhus, Denmark., Bybjerg-Grauholm J; iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark., Cai N; Statistical Genomics and Systems Genetics, European Bioinformatics Institute (EMBL-EBI), Cambridge, UK.; Human Genetics, Wellcome Trust Sanger Institute, Cambridge, UK., Castelao E; Department of Psychiatry, University Hospital of Lausanne, Prilly, Switzerland., Christensen JH; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; iSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, Denmark.; iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark., Clarke TK; Division of Psychiatry, University of Edinburgh, Edinburgh, UK., Coleman JIR; MRC Social Genetic and Developmental Psychiatry Centre, King's College London, London, UK., Colodro-Conde L; Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia., Couvy-Duchesne B; Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.; Centre for Advanced Imaging, University of Queensland, Brisbane, Queensland, Australia., Craddock N; Psychological Medicine, Cardiff University, Cardiff, UK., Crawford GE; Center for Genomic and Computational Biology, Duke University, Durham, NC, USA.; Department of Pediatrics, Division of Medical Genetics, Duke University, Durham, NC, USA., Crowley CA; Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Dashti HS; Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Davies G; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK., Deary IJ; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK., Degenhardt F; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Life & Brain Center, Department of Genomics, University of Bonn, Bonn, Germany., Derks EM; Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia., Direk N; Psychiatry, Dokuz Eylul University School of Medicine, Izmir, Turkey.; Epidemiology, Erasmus MC, Rotterdam, The Netherlands., Dolan CV; Department of Biological Psychology and EMGO+ Institute for Health and Care Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Dunn EC; Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.; Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.; Psychiatric and Neurodevelopmental Genetics Unit (PNGU), Massachusetts General Hospital, Boston, MA, USA., Eley TC; MRC Social Genetic and Developmental Psychiatry Centre, King's College London, London, UK., Eriksson N; Research, 23andMe, Inc., Mountain View, CA, USA., Escott-Price V; Neuroscience and Mental Health, Cardiff University, Cardiff, UK., Kiadeh FHF; Bioinformatics, University of British Columbia, Vancouver, British Columbia, Canada., Finucane HK; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.; Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA, USA., Forstner AJ; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Life & Brain Center, Department of Genomics, University of Bonn, Bonn, Germany.; Department of Psychiatry (UPK), University of Basel, Basel, Switzerland.; Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland., Frank J; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Gaspar HA; MRC Social Genetic and Developmental Psychiatry Centre, King's College London, London, UK., Gill M; Department of Psychiatry, Trinity College Dublin, Dublin, Ireland., Giusti-Rodríguez P; Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Goes FS; Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA., Gordon SD; Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Grove J; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; iSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, Denmark.; iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark., Hall LS; Division of Psychiatry, University of Edinburgh, Edinburgh, UK.; Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, UK., Hannon E; University of Exeter Medical School, Exeter, UK., Hansen CS; iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark., Hansen TF; Danish Headache Centre, Department of Neurology, Rigshospitalet, Glostrup, Denmark.; Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Capital Region of Denmark, Copenhagen, Denmark.; iPSYCH, Lundbeck Foundation Initiative for Psychiatric Research, Copenhagen, Denmark., Herms S; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Life & Brain Center, Department of Genomics, University of Bonn, Bonn, Germany.; Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland., Hickie IB; Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia., Hoffmann P; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Life & Brain Center, Department of Genomics, University of Bonn, Bonn, Germany.; Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland., Homuth G; Interfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, University Medicine and Ernst Moritz Arndt University Greifswald, Greifswald, Germany., Horn C; Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche, Ltd, Basel, Switzerland., Hottenga JJ; Department of Biological Psychology and EMGO+ Institute for Health and Care Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Hougaard DM; iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark., Hu M; Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA., Hyde CL; Statistics, Pfizer Global Research and Development, Groton, CT, USA., Ising M; Max Planck Institute of Psychiatry, Munich, Germany., Jansen R; Department of Psychiatry, Vrije Universiteit Medical Center and GGZ inGeest, Amsterdam, The Netherlands., Jin F; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA.; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA., Jorgenson E; Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA., Knowles JA; Psychiatry and Behavioral Sciences, University of Southern California, Los Angeles, CA, USA., Kohane IS; Informatics Program, Boston Children's Hospital, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA., Kraft J; Department of Psychiatry and Psychotherapy, Universitätsmedizin Berlin Campus Charité Mitte, Berlin, Germany., Kretzschmar WW; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Krogh J; Department of Endocrinology at Herlev University Hospital, University of Copenhagen, Copenhagen, Denmark., Kutalik Z; Swiss Institute of Bioinformatics, Lausanne, Switzerland.; Institute of Social and Preventive Medicine (IUMSP), University Hospital of Lausanne, Lausanne, Switzerland., Lane JM; Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA., Li Y; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Li Y; Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Lind PA; Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia., Liu X; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA., Lu L; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA., MacIntyre DJ; Mental Health, NHS 24, Glasgow, UK.; Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK., MacKinnon DF; Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA., Maier RM; Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia., Maier W; Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany., Marchini J; Statistics, University of Oxford, Oxford, UK., Mbarek H; Department of Biological Psychology and EMGO+ Institute for Health and Care Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., McGrath P; Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA., McGuffin P; MRC Social Genetic and Developmental Psychiatry Centre, King's College London, London, UK., Medland SE; Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia., Mehta D; Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.; School of Psychology and Counseling, Queensland University of Technology, Brisbane, Queensland, Australia., Middeldorp CM; Department of Biological Psychology and EMGO+ Institute for Health and Care Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Child and Youth Mental Health Service, Children's Health Queensland Hospital and Health Service, South Brisbane, Queensland, Australia.; Child Health Research Centre, University of Queensland, Brisbane, Queensland, Australia., Mihailov E; Estonian Genome Center, University of Tartu, Tartu, Estonia., Milaneschi Y; Department of Psychiatry, Vrije Universiteit Medical Center and GGZ inGeest, Amsterdam, The Netherlands., Milani L; Estonian Genome Center, University of Tartu, Tartu, Estonia., Mill J; University of Exeter Medical School, Exeter, UK., Mondimore FM; Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA., Montgomery GW; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., Mostafavi S; Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.; Statistics, University of British Columbia, Vancouver, British Columbia, Canada., Mullins N; MRC Social Genetic and Developmental Psychiatry Centre, King's College London, London, UK., Nauck M; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, University Medicine, University Medicine Greifswald, Greifswald, Germany.; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany., Ng B; Statistics, University of British Columbia, Vancouver, British Columbia, Canada., Nivard MG; Department of Biological Psychology and EMGO+ Institute for Health and Care Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Nyholt DR; Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia., O'Reilly PF; MRC Social Genetic and Developmental Psychiatry Centre, King's College London, London, UK., Oskarsson H; Humus, Reykjavik, Iceland., Owen MJ; MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Painter JN; Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia., Pedersen CB; iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Centre for Integrated Register-Based Research, Aarhus University, Aarhus, Denmark.; National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark., Pedersen MG; iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Centre for Integrated Register-Based Research, Aarhus University, Aarhus, Denmark.; National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark., Peterson RE; Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.; Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA., Pettersson E; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Peyrot WJ; Department of Psychiatry, Vrije Universiteit Medical Center and GGZ inGeest, Amsterdam, The Netherlands., Pistis G; Department of Psychiatry, University Hospital of Lausanne, Prilly, Switzerland., Posthuma D; Complex Trait Genetics, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Clinical Genetics, Vrije Universiteit Medical Center, Amsterdam, The Netherlands., Purcell SM; Department of Psychiatry, Brigham and Women's Hospital, Boston, MA, USA., Quiroz JA; Solid Biosciences, Boston, MA, USA., Qvist P; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; iSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, Denmark.; iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark., Rice JP; Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, MO, USA., Riley BP; Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA., Rivera M; MRC Social Genetic and Developmental Psychiatry Centre, King's College London, London, UK.; Department of Biochemistry and Molecular Biology II, Institute of Neurosciences, Center for Biomedical Research, University of Granada, Granada, Spain., Saeed Mirza S; Epidemiology, Erasmus MC, Rotterdam, The Netherlands., Saxena R; Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA., Schoevers R; Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Schulte EC; Department of Psychiatry and Psychotherapy, Medical Center of the University of Munich, Campus Innenstadt, Munich, Germany.; Institute of Psychiatric Phenomics and Genomics (IPPG), Medical Center of the University of Munich, Campus Innenstadt, Munich, Germany., Shen L; Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA., Shi J; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Shyn SI; Behavioral Health Services, Kaiser Permanente Washington, Seattle, WA, USA., Sigurdsson E; Faculty of Medicine, Department of Psychiatry, University of Iceland, Reykjavik, Iceland., Sinnamon GBC; School of Medicine and Dentistry, James Cook University, Townsville, Queensland, Australia., Smit JH; Department of Psychiatry, Vrije Universiteit Medical Center and GGZ inGeest, Amsterdam, The Netherlands., Smith DJ; Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK., Stefansson H; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland., Steinberg S; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland., Stockmeier CA; Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA., Streit F; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Strohmaier J; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Tansey KE; College of Biomedical and Life Sciences, Cardiff University, Cardiff, UK., Teismann H; Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany., Teumer A; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Thompson W; iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Capital Region of Denmark, Copenhagen, Denmark.; KG Jebsen Centre for Psychosis Research, Norway Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA., Thomson PA; Medical Genetics Section, CGEM, IGMM, University of Edinburgh, Edinburgh, UK., Thorgeirsson TE; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland., Tian C; Research, 23andMe, Inc., Mountain View, CA, USA., Traylor M; Clinical Neurosciences, University of Cambridge, Cambridge, UK., Treutlein J; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Trubetskoy V; Department of Psychiatry and Psychotherapy, Universitätsmedizin Berlin Campus Charité Mitte, Berlin, Germany., Uitterlinden AG; Internal Medicine, Erasmus MC, Rotterdam, The Netherlands., Umbricht D; Roche Pharmaceutical Research and Early Development, Neuroscience, Ophthalmology and Rare Diseases Discovery and Translational Medicine Area, Roche Innovation Center Basel, F. Hoffmann-La Roche, Ltd, Basel, Switzerland., Van der Auwera S; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany., van Hemert AM; Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands., Viktorin A; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Visscher PM; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.; Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia., Wang Y; iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Capital Region of Denmark, Copenhagen, Denmark.; KG Jebsen Centre for Psychosis Research, Norway Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., Webb BT; Virginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA., Weinsheimer SM; iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Capital Region of Denmark, Copenhagen, Denmark., Wellmann J; Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany., Willemsen G; Department of Biological Psychology and EMGO+ Institute for Health and Care Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Witt SH; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Wu Y; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., Xi HS; Computational Sciences Center of Emphasis, Pfizer Global Research and Development, Cambridge, MA, USA., Yang J; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.; Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia., Zhang F; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., Arolt V; Department of Psychiatry, University of Münster, Munster, Germany., Baune BT; Discipline of Psychiatry, University of Adelaide, Adelaide, South Australia, Australia., Berger K; Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany., Boomsma DI; Department of Biological Psychology and EMGO+ Institute for Health and Care Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Cichon S; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland.; Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany.; Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Basel, Switzerland., Dannlowski U; Department of Psychiatry, University of Münster, Munster, Germany., de Geus ECJ; Department of Biological Psychology and EMGO+ Institute for Health and Care Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Public Health Institute, Vrije Universiteit Medical Center, Amsterdam, The Netherlands., DePaulo JR; Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA., Domenici E; Centre for Integrative Biology, Università degli Studi di Trento, Trento, Italy., Domschke K; Department of Psychiatry and Psychotherapy, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Esko T; Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.; Estonian Genome Center, University of Tartu, Tartu, Estonia., Grabe HJ; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany., Hamilton SP; Psychiatry, Kaiser Permanente Northern California, San Francisco, CA, USA., Hayward C; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Heath AC; Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, MO, USA., Hinds DA; Research, 23andMe, Inc., Mountain View, CA, USA., Kendler KS; Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA., Kloiber S; Max Planck Institute of Psychiatry, Munich, Germany.; Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada., Lewis G; Division of Psychiatry, University College London, London, UK., Li QS; Neuroscience Therapeutic Area, Janssen Research and Development, LLC, Titusville, NJ, USA., Lucae S; Max Planck Institute of Psychiatry, Munich, Germany., Madden PFA; Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, MO, USA., Magnusson PK; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Martin NG; Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., McIntosh AM; Division of Psychiatry, University of Edinburgh, Edinburgh, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK., Metspalu A; Estonian Genome Center, University of Tartu, Tartu, Estonia.; Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia., Mors O; iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Psychosis Research Unit, Aarhus University Hospital, Risskov, Aarhus, Denmark., Mortensen PB; iSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, Denmark.; iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Centre for Integrated Register-Based Research, Aarhus University, Aarhus, Denmark.; National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark., Müller-Myhsok B; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; Institute of Translational Medicine, University of Liverpool, Liverpool, UK., Nordentoft M; iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Mental Health Center Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark., Nöthen MM; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Life & Brain Center, Department of Genomics, University of Bonn, Bonn, Germany., O'Donovan MC; MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Paciga SA; Human Genetics and Computational Biomedicine, Pfizer Global Research and Development, Groton, CT, USA., Pedersen NL; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Penninx BWJH; Department of Psychiatry, Vrije Universiteit Medical Center and GGZ inGeest, Amsterdam, The Netherlands., Perlis RH; Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.; Psychiatry, Harvard Medical School, Boston, MA, USA., Porteous DJ; Medical Genetics Section, CGEM, IGMM, University of Edinburgh, Edinburgh, UK., Potash JB; Psychiatry, University of Iowa, Iowa City, IA, USA., Preisig M; Department of Psychiatry, University Hospital of Lausanne, Prilly, Switzerland., Rietschel M; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Schaefer C; Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA., Schulze TG; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.; Institute of Psychiatric Phenomics and Genomics (IPPG), Medical Center of the University of Munich, Campus Innenstadt, Munich, Germany.; Human Genetics Branch, NIMH Division of Intramural Research Programs, Bethesda, MD, USA.; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany., Smoller JW; Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.; Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.; Psychiatric and Neurodevelopmental Genetics Unit (PNGU), Massachusetts General Hospital, Boston, MA, USA., Stefansson K; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Tiemeier H; Epidemiology, Erasmus MC, Rotterdam, The Netherlands.; Child and Adolescent Psychiatry, Erasmus MC, Rotterdam, The Netherlands.; Psychiatry, Erasmus MC, Rotterdam, The Netherlands., Uher R; Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada., Völzke H; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Weissman MM; Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA.; Division of Epidemiology, New York State Psychiatric Institute, New York, NY, USA., Werge T; iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Capital Region of Denmark, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Winslow AR; Human Genetics and Computational Biomedicine, Pfizer Global Research and Development, Cambridge, MA, USA.; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Lewis CM; MRC Social Genetic and Developmental Psychiatry Centre, King's College London, London, UK.; Department of Medical and Molecular Genetics, King's College London, London, UK., Levinson DF; Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA., Breen G; MRC Social Genetic and Developmental Psychiatry Centre, King's College London, London, UK.; NIHR BRC for Mental Health, King's College London, London, UK., Børglum AD; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; iSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, Denmark.; iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark., Sullivan PF; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. pfsulliv@med.unc.edu.; Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. pfsulliv@med.unc.edu.; Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. pfsulliv@med.unc.edu.

Publikováno v: Nature genetics [Nat Genet] 2018 May; Vol. 50 (5), pp. 668-681. Date of Electronic Publication: 2018 Apr 26.