Renal drug transporters and their significance in drug–drug interactions

Autor: Jia Yin, Joanne Wang

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 6, Iss 5, Pp 363-373 (2016)

The kidney is a vital organ for the elimination of therapeutic drugs and their metabolites. Renal drug transporters, which are primarily located in the renal proximal tubules, play an important role in tubular secretion and reabsorption of drug molec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7217cc1a65f4bf7866028e5df2970a9d
https://doi.org/10.1016/j.apsb.2016.07.013

Toxicological evaluation and metabolism of two

Autor: Donald S, Karanewsky, Amy J, Arthur, Hanghui, Liu, Bert, Chi, Lily, Ida

Publikováno v: Toxicology Reports

Toxicological evaluations of two N-alkyl benzamide umami flavour compounds, N-(heptan-4-yl)benzo[d][1,3]dioxole-5-carboxamide (S807, CAS 745047-51-2) and (R)-N-(1-methoxy-4-methylpentan-2-yl)-3,4-dimethylbenzamide (S9229, CAS 851669-60-8), were compl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::524e0c72486864471f513cad6066e211
https://pubmed.ncbi.nlm.nih.gov/28959612

Toxicological evaluation of a novel cooling compound: 2-(4-methylphenoxy)-N-(1H-pyrazol-3-yl)-N-(2-thienylmethyl)acetamide

Autor: Bert Chi, Amy J. Arthur, Hanghui Liu, Donald S. Karanewsky, Stacy Markison

Publikováno v: Toxicology Reports, Vol 2, Iss C, Pp 1291-1309 (2015)
Toxicology Reports

A toxicological evaluation of a novel cooling agent, 2-(4-methylphenoxy)-N-(1H-pyrazol-3-yl)-N-(2-thienylmethyl) acetamide (S2227; CAS 1374760-95-8), was completed for the purpose of assessing its safety for use in food and beverage applications. S22

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06d1e260dd2b23d9d5cd11c92f241eb3

Toxicological evaluation of the flavour ingredient N -(1-((4-amino-2,2-dioxido-1 H -benzo[ c ][1,2,6]thiadiazin-5-yl)oxy)-2-methylpropan-2-yl)-2,6-dimethylisonicotinamide (S2218).

Autor: Karanewsky DS; Senomyx, Inc., 4767 Nexus Centre Drive, San Diego, CA 92121, United States., Servant G; Senomyx, Inc., 4767 Nexus Centre Drive, San Diego, CA 92121, United States., Liu H; Senomyx, Inc., 4767 Nexus Centre Drive, San Diego, CA 92121, United States., Chi B; Senomyx, Inc., 4767 Nexus Centre Drive, San Diego, CA 92121, United States., Ida L; Senomyx, Inc., 4767 Nexus Centre Drive, San Diego, CA 92121, United States., Saganich M; Senomyx, Inc., 4767 Nexus Centre Drive, San Diego, CA 92121, United States., Werner S; Senomyx, Inc., 4767 Nexus Centre Drive, San Diego, CA 92121, United States., Fotsing JR; Senomyx, Inc., 4767 Nexus Centre Drive, San Diego, CA 92121, United States., Patron A; Senomyx, Inc., 4767 Nexus Centre Drive, San Diego, CA 92121, United States., Tachdjian C; Senomyx, Inc., 4767 Nexus Centre Drive, San Diego, CA 92121, United States., Arthur A; Senomyx, Inc., 4767 Nexus Centre Drive, San Diego, CA 92121, United States.

Publikováno v: Toxicology reports [Toxicol Rep] 2017 Sep 14; Vol. 4, pp. 507-520. Date of Electronic Publication: 2017 Sep 14 (Print Publication: 2017).

Renal drug transporters and their significance in drug-drug interactions.

Autor: Yin J; Department of Pharmaceutics, University of Washington, Seattle, WA 98195-7610, USA., Wang J; Department of Pharmaceutics, University of Washington, Seattle, WA 98195-7610, USA.

Publikováno v: Acta pharmaceutica Sinica. B [Acta Pharm Sin B] 2016 Sep; Vol. 6 (5), pp. 363-373. Date of Electronic Publication: 2016 Aug 09.