EP1230 Development of a pragmatic assay to assess homologous recombination competency in endometrial cancer

Autor: Mpg Vreeswijk, Tjalling Bosse, MM de Jonge, C.D. de Kroon, Violeta Serra, A Llop-Guevara, LM van Wijk, Cjh Kramer

Publikováno v: ePoster Talks: Ovarian + Endometria.

Introduction/Background Homologous recombination deficiency (HRD) is frequent in non-endometrioid endometrial cancer (EC), justifying clinical trials testing PARP-inhibitors. To facilitate this development a pragmatic test to asses HR competency is r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5d25dd5303ab57d50565eaef6472b4a8
https://doi.org/10.1136/ijgc-2019-esgo.64

Clinical Behavior and Molecular Landscape of Stage I p53-Abnormal Low-Grade Endometrioid Endometrial Carcinomas.

Autor: Jamieson A; Department of Gynecology and Obstetrics, Division of Gynecologic Oncology, University of British Columbia, Vancouver, Canada., Vermij L; Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands., Kramer CJH; Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands., Jobsen JJ; Department of Radiation Oncology, Medisch Spectrum Twente, Enschede, the Netherlands., Jürgemlienk-Schulz I; Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, the Netherlands., Lutgens L; MAASTRO Clinic, Maastricht, the Netherlands., Mens JW; Department of Radiation Oncology, Erasmus Medical Center, Rotterdam, the Netherlands., Haverkort MAD; Radiotherapiegroep Arnhem, Arnhem, the Netherlands., Slot A; Radiotherapeutic Institute Friesland, Leeuwarden, the Netherlands., Nout RA; Department of Radiation Oncology, Leiden University Medical Center, Leiden, the Netherlands., Oosting J; Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands., Carlson J; Department of Pathology, University of Southern California, Los Angeles., Howitt BE; Department of Pathology, Stanford University School of Medicine, Palo Alto., Ip PPC; Department of Pathology, University of Hong Kong, Pokfulam, Hong Kong SAR, China., Lax SF; Department of Pathology, Hospital Graz II, Medical University of Graz, Graz, and Johannes Kepler University, Linz, Austria., McCluggage WG; Department of Pathology, Belfast Health and Social Care Trust, Belfast, Northern Ireland, United Kingdom., Singh N; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada., McAlpine JN; Department of Gynecology and Obstetrics, Division of Gynecologic Oncology, University of British Columbia, Vancouver, Canada., Creutzberg CL; Department of Radiation Oncology, Leiden University Medical Center, Leiden, the Netherlands., Horeweg N; Department of Radiation Oncology, Leiden University Medical Center, Leiden, the Netherlands., Gilks CB; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada., Bosse T; Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2023 Dec 01; Vol. 29 (23), pp. 4949-4957.

The RAD51-FFPE Test; Calibration of a Functional Homologous Recombination Deficiency Test on Diagnostic Endometrial and Ovarian Tumor Blocks.

Autor: van Wijk LM; Department of Human Genetics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Kramer CJH; Department of Pathology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Vermeulen S; Department of Human Genetics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Ter Haar NT; Department of Pathology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., de Jonge MM; Department of Pathology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Kroep JR; Department of Medical Oncology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., de Kroon CD; Department of Gynecology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Gaarenstroom KN; Department of Gynecology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Vrieling H; Department of Human Genetics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Bosse T; Department of Pathology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands., Vreeswijk MPG; Department of Human Genetics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.

Publikováno v: Cancers [Cancers (Basel)] 2021 Jun 15; Vol. 13 (12). Date of Electronic Publication: 2021 Jun 15.

The prognostic value of tumour-stroma ratio in primary breast cancer with special attention to triple-negative tumours: a review.

Autor: Kramer CJH; Department of Surgery, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands., Vangangelt KMH; Department of Surgery, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands., van Pelt GW; Department of Surgery, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands., Dekker TJA; Department of Surgery, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands., Tollenaar RAEM; Department of Surgery, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands., Mesker WE; Department of Surgery, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands. w.e.mesker@lumc.nl.

Publikováno v: Breast cancer research and treatment [Breast Cancer Res Treat] 2019 Jan; Vol. 173 (1), pp. 55-64. Date of Electronic Publication: 2018 Oct 09.