A geometric approach to quantifying the neuromodulatory effects of persistent inward currents on single motor unit discharge patterns

Autor: James. A. Beauchamp, Gregory E. P. Pearcey, Obaid U. Khurram, Matthieu Chardon, Curtis Wang, Randall K. Powers, Julius P.A. Dewald, CJ. Heckman

ObjectiveAll motor commands flow through motoneurons, which entrain control of their innervated muscle fibers, forming a motor unit (MU). Owing to the high fidelity of action potentials within MUs, their discharge profiles detail the organization of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6145380b6cc1eb7e44c677d5c7812a58
https://doi.org/10.1101/2022.10.06.511149

Acute Attenuation of Motor Impairments With a Noradrenergic Pharmacological Agent in Chronic Hemiparetic Stroke

Autor: James Beauchamp, Sebastian Urday, Thomas Plaisier, CJ Heckman, Julius Dewald

Publikováno v: Archives of Physical Medicine and Rehabilitation. 103:e117

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5f7a49847ab12a096bfd35962468b5e8
https://doi.org/10.1016/j.apmr.2022.08.743

The MAPP research network: a novel study of urologic chronic pelvic pain syndromes

Autor: Yi Luo, Epifanio Bagarinao, CJ Heckman, Katherine Martucci, Kris Greiner, Todd Parrish, Michael O'Donnell, Timothy Ness, J Richard Landis, Ziya Kirkali, David Williams, Catherine Bradley, Garth Ehrlich, Karl Kreder, Graham Colditz, Sean Mackey

Publikováno v: BMC Urology

Urologic chronic pelvic pain syndrome (UCPPS) may be defined to include interstitial cystitis/bladder pain syndrome (IC/BPS) and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). The hallmark symptom of UCPPS is chronic pain in the pelvis,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e5cd9abdd533bf7eaecf004d12562aa
http://europepmc.org/articles/PMC4134515

Pharmacological blocking of spinal GABA A receptors in monkeys reduces sensory transmission to the spinal cord, thalamus, and cortex.

Autor: Mahrous AA; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Liang L; Rehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA; Center for Neural Basis of Cognition, Pittsburgh, PA, USA., Balaguer JM; Rehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA; Center for Neural Basis of Cognition, Pittsburgh, PA, USA., Ho JC; School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Grigsby EM; Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA, USA., Karapetyan V; Rehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA; Center for Neural Basis of Cognition, Pittsburgh, PA, USA., Damiani A; Rehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA; Center for Neural Basis of Cognition, Pittsburgh, PA, USA., Fields DP; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA., Gonzalez-Martinez JA; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA., Gerszten PC; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA., Bennett DJ; Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada; Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, AB, Canada., Heckman CJ; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Department of Physical Medicine and Rehabilitation, Shirley Ryan AbilityLab, Chicago, IL, USA., Pirondini E; Rehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA; Center for Neural Basis of Cognition, Pittsburgh, PA, USA; Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA, USA; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA; Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: elvirap@pitt.edu., Capogrosso M; Rehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA; Center for Neural Basis of Cognition, Pittsburgh, PA, USA; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA; Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: mcapo@pitt.edu.

Publikováno v: Cell reports [Cell Rep] 2024 Dec 18; Vol. 44 (1), pp. 115100. Date of Electronic Publication: 2024 Dec 18.

Supercomputer framework for reverse engineering firing patterns of neuron populations to identify their synaptic inputs.

Autor: Chardon MK; Department of Neuroscience, Northwestern University, Chicago, United States.; Northwestern-Argonne Institute of Science and Engineering (NAISE), Evanston, United States., Wang YC; Department of Electrical and Computer Engineering, California State University, Los Angeles, Los Angeles, United States., Garcia M; Argonne Leadership Computing Facility, Argonne National Laboratory, Lemont, United States., Besler E; Department of Electrical Engineering, Northwestern University, Evanston, United States., Beauchamp JA; Department of Biomedical Engineering, Northwestern University, Chicago, United States., D'Mello M; Intel Corporation, Santa Clara, United States., Powers RK; Department of Physiology and Biophysics, University of Washington, Seattle, United States., Heckman CJ; Department of Neuroscience, Northwestern University, Chicago, United States.; Physical Medicine and Rehabilitation, Shirley Ryan Ability Lab, Chicago, United States.; Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, United States.

Publikováno v: ELife [Elife] 2024 Oct 16; Vol. 12. Date of Electronic Publication: 2024 Oct 16.