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Akademický článek

Hypoexcitability precedes denervation in the large fast-contracting motor units in two unrelated mouse models of ALS

Autor: María de Lourdes Martínez-Silva, Rebecca D Imhoff-Manuel, Aarti Sharma, CJ Heckman, Neil A Shneider, Francesco Roselli, Daniel Zytnicki, Marin Manuel

Publikováno v: eLife, Vol 7 (2018)

Hyperexcitability has been suggested to contribute to motoneuron degeneration in amyotrophic lateral sclerosis (ALS). If this is so, and given that the physiological type of a motor unit determines the relative susceptibility of its motoneuron in ALS

Externí odkaz: https://doaj.org/article/e84ef059e33a431c86730f1b886b6e3d

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A geometric approach to quantifying the neuromodulatory effects of persistent inward currents on single motor unit discharge patterns

Autor: James. A. Beauchamp, Gregory E. P. Pearcey, Obaid U. Khurram, Matthieu Chardon, Curtis Wang, Randall K. Powers, Julius P.A. Dewald, CJ. Heckman

ObjectiveAll motor commands flow through motoneurons, which entrain control of their innervated muscle fibers, forming a motor unit (MU). Owing to the high fidelity of action potentials within MUs, their discharge profiles detail the organization of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6145380b6cc1eb7e44c677d5c7812a58
https://doi.org/10.1101/2022.10.06.511149

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A geometric approach to quantifying the neuromodulatory effects of persistent inward currents on individual motor unit discharge patterns

Autor: James A Beauchamp, Gregory E P Pearcey, Obaid U Khurram, Matthieu Chardon, Y Curtis Wang, Randall K Powers, Julius P A Dewald, CJ Heckman

Publikováno v: Journal of Neural Engineering. 20:016034

Objective. All motor commands flow through motoneurons, which entrain control of their innervated muscle fibers, forming a motor unit (MU). Owing to the high fidelity of action potentials within MUs, their discharge profiles detail the organization o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bbf6565959e9a572246a2dfc853ad12c
https://doi.org/10.1088/1741-2552/acb1d7

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Acute Attenuation of Motor Impairments With a Noradrenergic Pharmacological Agent in Chronic Hemiparetic Stroke

Autor: James Beauchamp, Sebastian Urday, Thomas Plaisier, CJ Heckman, Julius Dewald

Publikováno v: Archives of Physical Medicine and Rehabilitation. 103:e117

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5f7a49847ab12a096bfd35962468b5e8
https://doi.org/10.1016/j.apmr.2022.08.743

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A computational approach for generating continuous estimates of motor unit discharge rates and visualizing population discharge characteristics

Autor: James A Beauchamp, Obaid U Khurram, Julius P A Dewald, CJ Heckman, Gregory E P Pearcey

Publikováno v: Journal of neural engineering. 19(1)

Objective. Successive improvements in high density surface electromyography and decomposition techniques have facilitated an increasing yield in decomposed motor unit (MU) spike times. Though these advancements enhance the generalizability of finding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f9ba3ac5ed067b8faa54cc15cfc3835
https://pubmed.ncbi.nlm.nih.gov/34937005

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The MAPP research network: a novel study of urologic chronic pelvic pain syndromes

Autor: Yi Luo, Epifanio Bagarinao, CJ Heckman, Katherine Martucci, Kris Greiner, Todd Parrish, Michael O'Donnell, Timothy Ness, J Richard Landis, Ziya Kirkali, David Williams, Catherine Bradley, Garth Ehrlich, Karl Kreder, Graham Colditz, Sean Mackey

Publikováno v: BMC Urology

Urologic chronic pelvic pain syndrome (UCPPS) may be defined to include interstitial cystitis/bladder pain syndrome (IC/BPS) and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). The hallmark symptom of UCPPS is chronic pain in the pelvis,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e5cd9abdd533bf7eaecf004d12562aa
http://europepmc.org/articles/PMC4134515

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Alterations in synaptic input to motoneurons during partial spinal cord injury

Autor: CJ Heckman

Publikováno v: Scopus-Elsevier

An acute animal model (dorsal hemisection of the spinal cord in the decerebrate cat preparation) has been developed that closely mimics the spasticity in humans that occurs subsequent to partial spinal cord injury and hemiparetic stroke. In this anim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::616bc9a014f0883a5ff8ff35daac7f0b
https://pubmed.ncbi.nlm.nih.gov/7869883

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