Zobrazeno 1 - 10
of 82
pro vyhledávání: '"CJ Newton"'
Autor:
Annie K. Powell, Sabari Dutta, CJ Newton, Shreelekha Padhye, Subhash Padhye, Christopher E. Anson, Zahra Afrasiabi, Ekk Sinn
Publikováno v:
Journal of Inorganic Biochemistry. 95:306-314
The thiosemicarbazone derivative of 9,10-phenanthrenequinone, 1, and its metal complexes were synthesized. The X-ray crystal structure for 1 confirms the presence of the E tautomeric arrangement in this compound. Its copper complex shows 1:1 stoichio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7246dbc7e2765ee6e2d1aef5e7282735
https://doi.org/10.1016/s0162-0134(03)00131-4
https://doi.org/10.1016/s0162-0134(03)00131-4
Autor:
Peter T. McCollum, A Abidia, Ian P. Adams, Stephen L. Atkin, CJ Newton, Y.-X. Xie, C.H. Burgoyne
Publikováno v:
Cardiovascular Surgery. 11:52-60
Statins block de novo synthesis of cholesterol by inhibiting the enzyme, HMG CoA reductase. The product of this reaction, mevalonic acid, is also a precursor of isoprenoids, molecules required for the activation of signaling G-proteins, such as Ras.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95fbc817046ad55552992ad3773412ab
https://doi.org/10.1016/s0967-2109(02)00117-5
https://doi.org/10.1016/s0967-2109(02)00117-5
Publikováno v:
Journal of Endocrinology. 169:249-261
The oestrogen receptor is fundamental to the growth and survival of the rat pituitary tumour cell line, GH(3). Our previous studies have shown that antioestrogens such as RU 58668 and ZM 182780 will reduce the rate of cell division and also induce ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9343e2cd1900db4aacbb14413561891e
https://doi.org/10.1677/joe.0.1690249
https://doi.org/10.1677/joe.0.1690249
Autor:
Daniel L. Rathbone, David C. Billington, Subhash Padhye, Nikhil H. Gokhale, CJ Newton, Carl H. Schwalbe, P. R. Lowe
Publikováno v:
Inorganic Chemistry Communications. 4:26-29
The crystal structure of the neutral, distorted square planar copper(II) complex, viz. cis-[dichloro (N1-(2-benzyloxybenzylidene) pyridine-2-carboxamidrazone) copper(II)] (1) is reported which is the first well-characterized copper(II) complex of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6ad44995187ee348a3a5ae648d97c7f
https://doi.org/10.1016/s1387-7003(00)00185-4
https://doi.org/10.1016/s1387-7003(00)00185-4
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 73:29-38
Cell survival is dependent on both external and internally generated signalling processes and current strategies for medical intervention in neoplastic disease are directed towards signal transduction blockade. Redundancy in signalling pathways may m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f62f2db9bd2e57aa9dcb129dafdc637
https://doi.org/10.1016/s0960-0760(00)00047-9
https://doi.org/10.1016/s0960-0760(00)00047-9
Publikováno v:
Metal-Based Drugs
The C-3 substituted phenylazo derivatives of lawsone (2-hydroxy-l,4 p-naphthoquinone, III) were synthesized and characterized. The X-ray crystal structure was determined for the ligand 3-(3′-methyl phenylazo) lawsone. The copper complexes of these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b6b59857b787bce30c116b29d856e83
https://doi.org/10.1155/mbd.2000.121
https://doi.org/10.1155/mbd.2000.121
Autor:
Stephen L. Atkin, Peter T. McCollum, CJ Newton, D Bilko, G Ran, Y.-X. Xie, Ian P. Adams, A Abidia, CH Burgoyne
Publikováno v:
The Journal of endocrinology. 187(1)
The journal wishes to draw attention to a paper by C J Newton et al., ‘Fluvastatin induces apoptosis of vascular endothelial cells: blockade by glucocorticoids’, published in Cardiovascular Surgery 2003 11 52–60, that bears close similarity to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::636e58b022f4fa8d2b36c19eae8ac037
https://pubmed.ncbi.nlm.nih.gov/12543573
https://pubmed.ncbi.nlm.nih.gov/12543573
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(11)
A new semicarbazone derivative of curcumin (CRSC) was synthesized and examined for its antioxidant, antiproliferative, and antiradical activity and compared with those of curcumin (CR). The antioxidant activity was tested by their ability to inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88f79f87f17e838b5142d2c564c47ca3
https://pubmed.ncbi.nlm.nih.gov/15878268
https://pubmed.ncbi.nlm.nih.gov/15878268
Autor:
CJ Newton, Andrew R. Green, Stephen L. Atkin, David S. Walton, S B Desai, Speirs, Michael J. Kerin
Publikováno v:
Europe PubMed Central
Estrogen is mitogenic in breast cancer where IL-1beta also fulfils a role. The aim of this study was to determine any relationship between IL-1beta and ERalpha in breast cancer. By RT-PCR, 26/77 tumours expressed IL-1beta, and 57/77 expressed ERalpha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a5d171efbdeb8658376367e9014cc3d
https://doi.org/10.3892/ijo.15.6.1251
https://doi.org/10.3892/ijo.15.6.1251