LB1.64 Cd64-mediated phagocytosis of human syphilitic serum opsonizedtreponema pallidumby human macrophages required ifn-gamma

Autor: Juan C. Salazar, Lucero Ramírez, SL Benjamin, CJ La Vake, Justin D. Radolf, Morgan LeDoyt, Kelly L. Hawley, Adriana R. Cruz

Publikováno v: Systems Biology and Novel Technologies For Molecular Analysis and Diagnosis.

Introduction Syphilis is a multi-stage, sexually transmitted disease caused by the spirochete Treponema pallidum (Tp). Clinical manifestations result from the treponeme’s ability to elicit a robust immune response while at the same time evading hos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0ac89dfb9b8009d63cd6a6750f02ba75
https://doi.org/10.1136/sextrans-2017-053264.169

Treponema pallidum genetic diversity and its implications for targeted vaccine development: A cross-sectional study of early syphilis cases in Southwestern Colombia.

Autor: Salazar JC; Department of Pediatrics, University of Connecticut School of Medicine, Farmington, CT, United States of America.; Department of Immunology, University of Connecticut School of Medicine, Farmington, CT, United States of America.; Division of Infectious Diseases, Connecticut Children's, Hartford, CT, United States of America.; Centro Internacional de Entrenamiento e Investigaciones Médicas (CIDEIM), Cali, Colombia., Vargas-Cely F; Centro Internacional de Entrenamiento e Investigaciones Médicas (CIDEIM), Cali, Colombia., García-Luna JA; Centro Internacional de Entrenamiento e Investigaciones Médicas (CIDEIM), Cali, Colombia.; Universidad ICESI, Cali, Colombia.; Division of Dermatology, School of Medicine, Universidad del Valle, Cali, Colombia., Ramirez LG; Centro Internacional de Entrenamiento e Investigaciones Médicas (CIDEIM), Cali, Colombia.; Universidad ICESI, Cali, Colombia., Bettin EB; Department of Medicine, University of Connecticut School of Medicine, Farmington, CT, United States of America., Romero-Rosas N; Centro Internacional de Entrenamiento e Investigaciones Médicas (CIDEIM), Cali, Colombia., Amórtegui MF; Centro Internacional de Entrenamiento e Investigaciones Médicas (CIDEIM), Cali, Colombia., Silva S; Centro Internacional de Entrenamiento e Investigaciones Médicas (CIDEIM), Cali, Colombia., Oviedo O; Centro Internacional de Entrenamiento e Investigaciones Médicas (CIDEIM), Cali, Colombia., Vigil J; Department of Pediatrics, University of Connecticut School of Medicine, Farmington, CT, United States of America., La Vake CJ; Department of Pediatrics, University of Connecticut School of Medicine, Farmington, CT, United States of America., Galindo X; Corporación de Lucha Contra el SIDA, Cali, Colombia., Ramirez JD; Centro Internacional de Entrenamiento e Investigaciones Médicas (CIDEIM), Cali, Colombia., Martínez-Valencia AJ; Centro Internacional de Entrenamiento e Investigaciones Médicas (CIDEIM), Cali, Colombia.; Universidad ICESI, Cali, Colombia., Caimano MJ; Department of Pediatrics, University of Connecticut School of Medicine, Farmington, CT, United States of America.; Department of Medicine, University of Connecticut School of Medicine, Farmington, CT, United States of America.; Department of Molecular Biology and Biophysics, UConn Health, Farmington, CT, United States of America., Hennelly CM; Institute for Global Health and Infectious Diseases, University of North Carolina, Chapel Hill, NC, United States of America., Aghakhanian F; Institute for Global Health and Infectious Diseases, University of North Carolina, Chapel Hill, NC, United States of America., Moody MA; Duke Human Vaccine Institute, Durham, NC, United States of America.; Department of Pediatrics, Duke University Medical Center, Durham, NC, United States of America.; Department of Integrative Immunology, Duke University Medical Center, Durham, NC, United States of America., Seña AC; Institute for Global Health and Infectious Diseases, University of North Carolina, Chapel Hill, NC, United States of America., Parr JB; Institute for Global Health and Infectious Diseases, University of North Carolina, Chapel Hill, NC, United States of America., Hawley KL; Department of Pediatrics, University of Connecticut School of Medicine, Farmington, CT, United States of America.; Department of Immunology, University of Connecticut School of Medicine, Farmington, CT, United States of America.; Division of Infectious Diseases, Connecticut Children's, Hartford, CT, United States of America.; Department of Medicine, University of Connecticut School of Medicine, Farmington, CT, United States of America., López-Medina E; Centro Internacional de Entrenamiento e Investigaciones Médicas (CIDEIM), Cali, Colombia.; Centro de Estudios en Infectología Pediátrica (CEIP), Cali, Colombia., Radolf JD; Department of Pediatrics, University of Connecticut School of Medicine, Farmington, CT, United States of America.; Department of Immunology, University of Connecticut School of Medicine, Farmington, CT, United States of America.; Centro Internacional de Entrenamiento e Investigaciones Médicas (CIDEIM), Cali, Colombia.; Department of Medicine, University of Connecticut School of Medicine, Farmington, CT, United States of America.; Department of Genetics and Genome Sciences, UConn Health, Farmington, CT, United States of America.

Publikováno v: PloS one [PLoS One] 2024 Jul 19; Vol. 19 (7), pp. e0307600. Date of Electronic Publication: 2024 Jul 19 (Print Publication: 2024).

Extracellular Loops of the Treponema pallidum FadL Orthologs TP0856 and TP0858 Elicit IgG Antibodies and IgG ⁺ -Specific B-Cells in the Rabbit Model of Experimental Syphilis.

Autor: Delgado KN; Department of Medicine, UConn Health, Farmington, Connecticut, USA., Montezuma-Rusca JM; Department of Medicine, UConn Health, Farmington, Connecticut, USA.; Division of Infectious Diseases, UConn Health, Farmington, Connecticut, USA.; Department of Pediatrics, UConn Health, Farmington, Connecticut, USA., Orbe IC; Department of Pediatrics, UConn Health, Farmington, Connecticut, USA., Caimano MJ; Department of Medicine, UConn Health, Farmington, Connecticut, USA.; Department of Pediatrics, UConn Health, Farmington, Connecticut, USA.; Department of Molecular Biology and Biophysics, UConn Health, Farmington, Connecticut, USA., La Vake CJ; Department of Pediatrics, UConn Health, Farmington, Connecticut, USA., Luthra A; Department of Medicine, UConn Health, Farmington, Connecticut, USA.; Department of Molecular Biology and Biophysics, UConn Health, Farmington, Connecticut, USA., Hennelly CM; Division of Infectious Diseases, Department of Medicine, and Institute for Global Health and Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina, USA., Nindo FN; Division of Infectious Diseases, Department of Medicine, and Institute for Global Health and Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina, USA., Meyer JW; Duke Human Vaccine Institute, Durham, North Carolina, USA., Jones LD; Duke Human Vaccine Institute, Durham, North Carolina, USA., Parr JB; Division of Infectious Diseases, Department of Medicine, and Institute for Global Health and Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina, USA., Salazar JC; Department of Pediatrics, UConn Health, Farmington, Connecticut, USA.; Division of Infectious Diseases and Immunology, Connecticut Children's, Hartford, Connecticut, USA.; Department of Immunology, UConn Health, Farmington, Connecticut, USA., Moody MA; Duke Human Vaccine Institute, Durham, North Carolina, USA.; Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA.; Department of Immunology, Duke University Medical Center, Durham, North Carolina, USA., Radolf JD; Department of Medicine, UConn Health, Farmington, Connecticut, USA.; Department of Pediatrics, UConn Health, Farmington, Connecticut, USA.; Department of Molecular Biology and Biophysics, UConn Health, Farmington, Connecticut, USA.; Department of Immunology, UConn Health, Farmington, Connecticut, USA.; Department of Genetics and Genome Sciences, UConn Health, Farmington, Connecticut, USA., Hawley KL; Department of Medicine, UConn Health, Farmington, Connecticut, USA.; Department of Pediatrics, UConn Health, Farmington, Connecticut, USA.; Division of Infectious Diseases and Immunology, Connecticut Children's, Hartford, Connecticut, USA.

Publikováno v: MBio [mBio] 2022 Aug 30; Vol. 13 (4), pp. e0163922. Date of Electronic Publication: 2022 Jul 12.

Evidence that immunization with TP0751, a bipartite Treponema pallidum lipoprotein with an intrinsically disordered region and lipocalin fold, fails to protect in the rabbit model of experimental syphilis.

Autor: Luthra A; Department of Medicine, UConn Health, Farmington, United States of America., Montezuma-Rusca JM; Department of Medicine, UConn Health, Farmington, United States of America.; Division of Infectious Diseases, UConn Health, Farmington, United States of America.; Department of Pediatrics, UConn Health, Farmington, United States of America., La Vake CJ; Department of Pediatrics, UConn Health, Farmington, United States of America., LeDoyt M; Department of Medicine, UConn Health, Farmington, United States of America., Delgado KN; Department of Medicine, UConn Health, Farmington, United States of America., Davenport TC; Department of Medicine, UConn Health, Farmington, United States of America., Fiel-Gan M; Department of Pathology, Hartford Hospital, Hartford, United States of America., Caimano MJ; Department of Medicine, UConn Health, Farmington, United States of America.; Department of Pediatrics, UConn Health, Farmington, United States of America.; Department of Molecular Biology and Biophysics, UConn Health, Farmington, United States of America., Radolf JD; Department of Medicine, UConn Health, Farmington, United States of America.; Department of Pediatrics, UConn Health, Farmington, United States of America.; Department of Molecular Biology and Biophysics, UConn Health, Farmington, United States of America.; Department of Genetics and Genome Sciences, UConn Health, Farmington, United States of America.; Department of Immunology, UConn Health, Farmington, United States of America., Hawley KL; Department of Pediatrics, UConn Health, Farmington, United States of America.; Division of Infectious Diseases and Immunology, Connecticut Children's, Hartford, United States of America.

Publikováno v: PLoS pathogens [PLoS Pathog] 2020 Sep 16; Vol. 16 (9), pp. e1008871. Date of Electronic Publication: 2020 Sep 16 (Print Publication: 2020).

IFNγ Enhances CD64-Potentiated Phagocytosis of Treponema pallidum Opsonized with Human Syphilitic Serum by Human Macrophages.

Autor: Hawley KL; Department of Pediatrics, UConn Health, Farmington, CT, United States.; Division of Infectious Diseases, Connecticut Children's Medical Center, Hartford, CT, United States., Cruz AR; Centro Internacional de Entrenamiento e Investigaciones Médicas (CIDEIM), Cali, Colombia., Benjamin SJ; Department of Pediatrics, UConn Health, Farmington, CT, United States.; Division of Infectious Diseases, Connecticut Children's Medical Center, Hartford, CT, United States.; Department of Immunology, UConn Health, Farmington, CT, United States., La Vake CJ; Department of Pediatrics, UConn Health, Farmington, CT, United States., Cervantes JL; Department of Pediatrics, UConn Health, Farmington, CT, United States.; Division of Infectious Diseases, Connecticut Children's Medical Center, Hartford, CT, United States., LeDoyt M; Department of Medicine, UConn Health, Farmington, CT, United States., Ramirez LG; Centro Internacional de Entrenamiento e Investigaciones Médicas (CIDEIM), Cali, Colombia., Mandich D; Department of Pathology, Hartford Hospital, Hartford, CT, United States., Fiel-Gan M; Department of Pathology, Hartford Hospital, Hartford, CT, United States., Caimano MJ; Department of Medicine, UConn Health, Farmington, CT, United States., Radolf JD; Department of Pediatrics, UConn Health, Farmington, CT, United States.; Division of Infectious Diseases, Connecticut Children's Medical Center, Hartford, CT, United States.; Centro Internacional de Entrenamiento e Investigaciones Médicas (CIDEIM), Cali, Colombia.; Department of Immunology, UConn Health, Farmington, CT, United States.; Department of Medicine, UConn Health, Farmington, CT, United States.; Department of Genetics and Developmental Biology, UConn Health, Farmington, CT, United States., Salazar JC; Department of Pediatrics, UConn Health, Farmington, CT, United States.; Division of Infectious Diseases, Connecticut Children's Medical Center, Hartford, CT, United States.; Centro Internacional de Entrenamiento e Investigaciones Médicas (CIDEIM), Cali, Colombia.; Department of Immunology, UConn Health, Farmington, CT, United States.

Publikováno v: Frontiers in immunology [Front Immunol] 2017 Oct 05; Vol. 8, pp. 1227. Date of Electronic Publication: 2017 Oct 05 (Print Publication: 2017).