Changes in sick notes associated with COVID-19 from 2020 to 2022: a cohort study in 24 million primary care patients in OpenSAFELY-TPP

Autor: Andrew Steptoe, John Macleod, Daniel McCartney, Aziz Sheikh, Annie Herbert, Ben Goldacre, David Evans, Louise Jones, Sam Harper, Michael Green, Nicholas Timpson, John Wright, Liam Smeeth, Laurie A Tomlinson, Sinead Brophy, Kate Tilling, Andy Gibson, Paola Zaninotto, Stefan Neubauer, Yinghui Wei, Betty Raman, Chloe Park, Alun Hughes, Jonathan Sterne, Elena Lukaschuk, Stefan Piechnik, Angela Wood, Mark Green, Agnieszka Lemanska, Krishnan Bhaskaran, Kathryn Willan, Elsie Horne, Hannah Woodward, Ian Douglas, Andrew Wong, Andy Boyd, Harriet Forbes, Sinéad Langan, Nishi Chaturvedi, Tom Palmer, Kathryn Mansfield, Rachel Denholm, Emily Herrett, Kevin Wang, Bo Hou, Felix Greaves, Laura Sheard, Praveetha Patalay, Kishan Patel, Jessica Morley, Bang Zheng, Charlotte Booth, Spiros Denaxas, Brian MacKenna, Ruth E Costello, Jonathan Kennedy, William Hulme, Michael Parker, Geneviève Cezard, Syed A Shah, Amir Mehrkar, Peter Inglesby, Jonathan Cockburn, Laurie Tomlinson, John Parry, Frank Hester, Eoin McElroy, Amelia Green, Gillian Santorelli, Alisia Carnemolla, Richard Shaw, Samantha Ip, Venexia Walker, Emma L Turner, Richard Thomas, Rebecca Rhead, Archie Campbell, Ellen Thompson, Ruth Bowyer, Jane Maddock, Helen Curtis, Alex Walker, Olivia Hamilton, Rosie McEachan, Ellena Badrick, Stephen Smith, Richard Dobson, Stela McLachlan, Vanessa Ferreira, Vittal Katikireddi, Scott Walker, Lucy Teece, Simon Davy, John Tazare, Bettina Moltrecht, Theocharis Kromydas, Giorgio Di Gessa, Gareth Griffith, Viyaasan Mahalingasivam, Elizabeth Tunnicliffe, George Hickman, Tom Ward, Rebecca M Smith, Sam Parsons, Callum Stewart, Amos Folarin, Daniel Kopasker, Claire Steves, Louis Fisher, Sebastian C J Bacon, Lisa Hopcroft, Robin Y Park, Jon Massey, Iain Dillingham, Steven Maude, Wels Jacques, Linda Nab, Christopher Bates, Milan Wiedemann, Ruth Mitchell, Chao Fang, Fatima Almaghrabi, Jingmin Zhu, Lucy Bridges, Kurt Taylor, Colm Andrews, Jean Stafford, Nathan Cheetham, Sebastian CJ Bacon, Alicja Rapala, Robin Flaig, Andrea L Schaffer, Benjamin FC Butler-Cole, Liam Hart Ben Goldacre, Thomas O’Dwyer, Dylan Williams, Anika Knueppel, Katharine M Evans, Samantha Berman, Matthew Crane, Rebecca Whitehorn, Jacqui Oakley, Diane Foster, Kirsteen C Campbell, Alex Kwong, Ana Goncalves Soares, Renin Toms, Lizzie Huntley, Laura Fox, Rochelle Knight, Northstone Kate, Kanagaratnam Arun, Teri North, Marwa AL Arab, Jose IC Coronado, Arun S Karthikeyan, Ploubidis George, Bozena Wielgoszewska, Charis Bridger-Staatz, Paz Garcia, Maxim Freydin, Amy Roberts, Alex Walker Ben Goldacre, Jess Morley, Anoop Shah Richard Silverwood, Thomas Cowling, Kate Mansfield, Tiffany Yang, Tom Bolton, Alexia Sampri, Elena Rafeti, Robert Willans, Fiona Glen, Steve Sharp, Lee Hamill Howes, Lidia Nigrelli, Fintan McArdle, Chelsea Beckford, Yatharth Ranjan, Jd Carpentieri, Sarah Baz, John Kellas, Laura C Saunders, James M Wild, Peter Jezzard, Zeena-Britt Sanders, Lucy Finnigan, Milla Kibble, Francisco Perez-Reche, Dominik Piehlmaier, Edward Parker

Publikováno v: BMJ Open, Vol 14, Iss 7 (2024)

Objectives Long-term sickness absence from employment has negative consequences for the economy and can lead to widened health inequalities. Sick notes (also called ‘fit notes’) are issued by general practitioners when a person cannot work for he

Externí odkaz: https://doaj.org/article/1038a096d89044e5a8996a5c8992b394

Data-Driven Identification of Unusual Prescribing Behavior: Analysis and Use of an Interactive Data Tool Using 6 Months of Primary Care Data From 6500 Practices in England

Autor: Lisa EM Hopcroft, Jon Massey, Helen J Curtis, Brian Mackenna, Richard Croker, Andrew D Brown, Thomas O'Dwyer, Orla Macdonald, David Evans, Peter Inglesby, Sebastian CJ Bacon, Ben Goldacre, Alex J Walker

Publikováno v: JMIR Medical Informatics, Vol 11, p e44237 (2023)

BackgroundApproaches to addressing unwarranted variation in health care service delivery have traditionally relied on the prospective identification of activities and outcomes, based on a hypothesis, with subsequent reporting against defined measures

Externí odkaz: https://doaj.org/article/78aa556f4b534078bc862772c0b702c4

Recording of ’COVID-19 vaccine declined‘: a cohort study on 57.9 million National Health Service patients’ records in situ using OpenSAFELY, England, 8 December 2020 to 25 May 2021

Autor: Helen J Curtis, Peter Inglesby, Brian MacKenna, Richard Croker, William J Hulme, Christopher T Rentsch, Krishnan Bhaskaran, Rohini Mathur, Caroline E Morton, Sebastian CJ Bacon, Rebecca M Smith, David Evans, Amir Mehrkar, Laurie Tomlinson, Alex J Walker, Christopher Bates, George Hickman, Tom Ward, Jessica Morley, Jonathan Cockburn, Simon Davy, Elizabeth J Williamson, Rosalind M Eggo, John Parry, Frank Hester, Sam Harper, Shaun O’Hanlon, Alex Eavis, Richard Jarvis, Dima Avramov, Paul Griffiths, Aaron Fowles, Nasreen Parkes, Stephen JW Evans, Ian J Douglas, Liam Smeeth, Ben Goldacre

Publikováno v: Eurosurveillance. 27

Background Priority patients in England were offered COVID-19 vaccination by mid-April 2021. Codes in clinical record systems can denote the vaccine being declined. Aim We describe records of COVID-19 vaccines being declined, according to clinical an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d05ce3914ff3672402ae23d417cdcad2
https://doi.org/10.2807/1560-7917.es.2022.27.33.2100885

A hypothesis-free data science approach to identifying novel patterns of clinical interest in clinicians' treatment preferences: clusters of high Pericyazine and Promazine use in England (Preprint)

Autor: Brian MacKenna, Helen J Curtis, Alex J Walker, Richard Croker, Orla Macdonald, Stephen JW Evans, Peter Inglesby, Dave Evans, Jessica Morley, Sebastian CJ Bacon, Ben Goldacre

BACKGROUND Data analysis can be used to identify signals suggestive of variation in treatment choice or clinical outcome. Analyses to date have generally focused on an hypothesis-driven approach. OBJECTIVE Develop hypothesis-blind data driven approac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::166e1a6d586ace0b2086c81c1f173293
https://doi.org/10.2196/preprints.41200

Comparative effectiveness of sotrovimab and molnupiravir for prevention of severe COVID-19 outcomes in non-hospitalised patients: an observational cohort study using the OpenSAFELY platform

Autor: Bang Zheng, Amelia CA Green, John Tazare, Helen J Curtis, Louis Fisher, Linda Nab, Anna Schultze, Viyaasan Mahalingasivam, Edward PK Parker, William J Hulme, Sebastian CJ Bacon, Nicholas J DeVito, Christopher Bates, David Evans, Peter Inglesby, Henry Drysdale, Simon Davy, Jonathan Cockburn, Caroline E Morton, George Hickman, Tom Ward, Rebecca M Smith, John Parry, Frank Hester, Sam Harper, Amir Mehrkar, Rosalind M Eggo, Alex J Walker, Stephen JW Evans, Ian J Douglas, Brian MacKenna, Ben Goldacre, Laurie A Tomlinson

ObjectiveTo compare the effectiveness of sotrovimab (a neutralising monoclonal antibody) vs. molnupiravir (an antiviral) in preventing severe COVID-19 outcomes in non-hospitalised high-risk COVID-19 adult patients.DesignWith the approval of NHS Engla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e16cfce8c8f2d7ab162808942dff7426
https://doi.org/10.1101/2022.05.22.22275417