GHSR blockade, but not reduction of peripherally circulating ghrelin via β 1 -adrenergic receptor antagonism, decreases binge-like alcohol drinking in mice.

Autor: Richardson RS; Clinical Psychoneuroendocrinology and Neuropsychopharmacology Section, Translational Addiction Medicine Branch, National Institute on Drug Abuse Intramural Research Program and National Institute on Alcohol Abuse and Alcoholism Division of Intramural Clinical and Biological Research, National Institutes of Health, Baltimore and Bethesda, MD, USA.; Neurobiology of Addiction Section, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.; University of North Carolina School of Medicine MD/PhD Program, University of North Carolina, Chapel Hill, NC, USA.; Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC, USA.; Stress and Addiction Neuroscience Unit, National Institute on Drug Abuse Intramural Research Program and National Institute on Alcohol Abuse and Alcoholism Division of Intramural Clinical and Biological Research, National Institutes of Health, Baltimore, MD, USA., Kryszak LA; National Institute on Drug Abuse Intramural Research Program Translational Analytical Core, National Institutes of Health, Baltimore, MD, USA., Vendruscolo JCM; Neurobiology of Addiction Section, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.; Stress and Addiction Neuroscience Unit, National Institute on Drug Abuse Intramural Research Program and National Institute on Alcohol Abuse and Alcoholism Division of Intramural Clinical and Biological Research, National Institutes of Health, Baltimore, MD, USA., Koob GF; Neurobiology of Addiction Section, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD, USA., Vendruscolo LF; Stress and Addiction Neuroscience Unit, National Institute on Drug Abuse Intramural Research Program and National Institute on Alcohol Abuse and Alcoholism Division of Intramural Clinical and Biological Research, National Institutes of Health, Baltimore, MD, USA. leandro.vendruscolo@nih.gov., Leggio L; Clinical Psychoneuroendocrinology and Neuropsychopharmacology Section, Translational Addiction Medicine Branch, National Institute on Drug Abuse Intramural Research Program and National Institute on Alcohol Abuse and Alcoholism Division of Intramural Clinical and Biological Research, National Institutes of Health, Baltimore and Bethesda, MD, USA. lorenzo.leggio@nih.gov.; National Institute on Drug Abuse Intramural Research Program Translational Analytical Core, National Institutes of Health, Baltimore, MD, USA. lorenzo.leggio@nih.gov.; Department of Behavioral and Social Sciences, Center for Alcohol and Addiction Studies, Brown University, Providence, RI, USA. lorenzo.leggio@nih.gov.; Medication Development Program, Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA. lorenzo.leggio@nih.gov.; Division of Addiction Medicine, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA. lorenzo.leggio@nih.gov.; Department of Neuroscience, Georgetown University Medical Center, Washington, DC, USA. lorenzo.leggio@nih.gov.

Publikováno v: Molecular psychiatry [Mol Psychiatry] 2024 Sep 05. Date of Electronic Publication: 2024 Sep 05.

Circulating ghrelin crosses the blood-cerebrospinal fluid barrier via growth hormone secretagogue receptor dependent and independent mechanisms

Autor: Uriarte, Maia, De Francesco, Pablo N., Fernández, Gimena, Castrogiovanni, Daniel, D'Arcangelo, Micaela, Imbernon, Mónica, Cantel, Sonia, Denoyelle, Severine, Fehrentz, Jean-Alain, Praetorius, Jeppe, Prevot, Vincent, Perello, Mario

Publikováno v: In Molecular and Cellular Endocrinology 1 December 2021 538

Circulating ghrelin levels in patients with gastric cancer: a systematic review and meta-analysis

Autor: Yuxuan Wang, Caishun Zhang, Jiaqing Yu, Qing Zhang, Yukai Wang, Yunqiu Xia, Jing Dong

Publikováno v: Frontiers in Oncology, Vol 13 (2023)

BackgroundGhrelin plays a critical role in regulating energy metabolism and homeostasis. The association between circulating ghrelin levels and gastric cancer has not been systematically analyzed.ObjectiveThis work explored the association between ci

Externí odkaz: https://doaj.org/article/7082b02dd9ee4d07b3e826eb57d7e015

A randomized crossover trial assessing the effects of acute exercise on appetite, circulating ghrelin concentrations, and butyrylcholinesterase activity in normal-weight males with variants of the obesity-linked FTO rs9939609 polymorphism

Autor: Dorling, James L, Clayton, David J, Jones, Jenny, Carter, Wayne G, Thackray, Alice E, King, James A, Pucci, Andrea, Batterham, Rachel L ^*, Stensel, David J ^*

Publikováno v: In The American Journal of Clinical Nutrition November 2019 110(5):1055-1066

CIRCULATING GHRELIN LEVELS AND SUSCEPTIBILITY TO COLORECTAL CÂNCER

Autor: Asadollah ASADI, Hamid FARAHANI, Touraj MAHMOUDI, Seidamir Pasha TABAEIAN, Gholamreza REZAMAND, Abolfazl MOHAMMADBEIGI, Reza DABIRI, Hossein NOBAKHT, Sajad REZVAN, Fatemeh MOHAMMADI

Publikováno v: Arquivos de Gastroenterologia, Vol 58, Iss 3, Pp 316-321 (2021)

ABSTRACT BACKGROUND AND OBJECTIVE: Considering the association between colorectal cancer (CRC) and both insulin resistance and obesity, and the prominent role of ghrelin in these metabolic disorders, we explored whether plasma levels of ghrelin were

Externí odkaz: https://doaj.org/article/e394a3437d8843a985681033f4350637