Value of peri-operative chemotherapy in patients with CINSARC high-risk localized grade 1 or 2 soft tissue sarcoma: study protocol of the target selection phase III CHIC-STS trial

Autor: Thomas Filleron, Sophie Le Guellec, Christine Chevreau, Bastien Cabarrou, Tom Lesluyes, Sabrina Lodin, Angélique Massoubre, Muriel Mounier, Muriel Poublanc, Frédéric Chibon, Thibaud Valentin

Publikováno v: BMC Cancer, Vol 20, Iss 1, Pp 1-8 (2020)

Abstract Background The value of chemotherapy in soft tissue sarcoma (STS) remains controversial. Several expert teams consider that chemotherapy provides a survival advantage and should be proposed in high-risk (HR) patients. However, the lack of ac

Externí odkaz: https://doaj.org/article/95159104642d44afbaa194669e03e23a

CINSARC in high-risk soft tissue sarcoma patients treated with neoadjuvant chemotherapy: Results from the ISG-STS 1001 study

Autor: Anna Maria Frezza, Silvia Stacchiotti, Frederic Chibon, Jean‐Michelle Coindre, Antoine Italiano, Cleofe Romagnosa, Silvia Bagué, Angelo Paolo Dei Tos, Luca Braglia, Emanuela Palmerini, Vittorio Quagliuolo, Javier Martin Broto, Antonio Lopez Pousa, Giovanni Grignani, Antonella Brunello, Jean‐Yves Blay, Robert Diaz Beveridge, Iwona Lugowska, Tom Lesluyes, Roberta Maestro, Franco Domenico Merlo, Paolo Giovanni Casali, Alessandro Gronchi

Publikováno v: Cancer Medicine
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau

Background The Complexity INdex in SARComas (CINSARC) is a transcriptional signature derived from the expression of 67 genes involved in mitosis control and chromosome integrity. This study aims to assess CINSARC value of in an independent series of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d81cbaae0de1b0e615225e8e7249247
https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=16940

Is there a link between genomic complexity and clinical outcome in uterine smooth muscle tumors?

Autor: Croce, Sabrina

Publikováno v: Médecine humaine et pathologie. Université de Lyon, 2020. Français. ⟨NNT : 2020LYSE1071⟩

Sarcomas with complex genomics such as leiomyosarcomas (LMS) are characterized by an altered genome in the absence of a known recurrent "driver" genomic event. According to their clinical outcome, smooth muscle uterine tumours are divided into leiomy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1398::a24055eaf2908740006e1b6aa3bacc81
https://theses.hal.science/tel-03358145

Heterogeneity in sarcoma cell lines reveals enhanced motility of tetraploid versus diploid cells

Autor: Nathalie Morin, Catherine Teyssier, Mohamed Jemaà, Pierre Roux, Frédéric Chibon, Gwendaline Lledo, Ariane Abrieu, Gaëlle Pérot, Samer Abdallah, Juliette van Dijk, Tom Lesluyes

Publikováno v: Oncotarget
Oncotarget, Impact journals, 2017, 8 (10), ⟨10.18632/oncotarget.14291⟩
Oncotarget, 2017, 8 (10), ⟨10.18632/oncotarget.14291⟩

// Mohamed Jemaa 1, 2 , Samer Abdallah 1, 2 , Gwendaline Lledo 1, 2 , Gaelle Perrot 3 , Tom Lesluyes 3 , Catherine Teyssier 4 , Pierre Roux 1, 2 , Juliette van Dijk 1, 2 , Frederic Chibon 3, 5 , Ariane Abrieu 1, 2 , Nathalie Morin 1, 2 1 Universites

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c1811293ed6c9d38f08347d44de4992
https://hal.archives-ouvertes.fr/hal-01875251/file/oncotarget-08-16669.pdf

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