Zobrazeno 1 - 10
of 24
pro vyhledávání: '"CIMP, CpG island methylator phenotype"'
Autor:
Sarah Holte, Jianjun Paul Tian, Frank Szulzewsky, Xianyi Zeng, Eric C. Holland, Ben Niu, Tuan Anh Phan
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 9, Pp 323-332 (2020)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
Background: Tumor-infiltrated immune cells compose a significant component of many cancers. They have been observed to have contradictory impacts on tumors. Although the primary reasons for these observations remain elusive, it is important to unders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2021e2b4c96d64bffc23e51a393dd57f
http://www.sciencedirect.com/science/article/pii/S1476558620301226
http://www.sciencedirect.com/science/article/pii/S1476558620301226
Autor:
Cheng Liu, Ann-Marie Patch, Lambros T. Koufariotis, Vicki L. J. Whitehall, Jennifer Borowsky, Stephen H. Kazakoff, John V. Pearson, Catherine Bond, Nicola Waddell, Barbara A. Leggett, Diane McKeone, Lochlan Fennell, Alexandra M. Kane
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 2, Pp 120-128 (2020)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
The serrated neoplasia pathway gives rise to a distinct subgroup of colorectal cancers distinguished by the presence of mutant BRAFV600E and the CpG Island Methylator Phenotype (CIMP). BRAF mutant CRC are commonly associated with microsatellite insta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::260bfe1ede9704d895b5f687e5f51c6b
https://doi.org/10.1016/j.neo.2019.12.002
https://doi.org/10.1016/j.neo.2019.12.002
Autor:
Hyun Yang Yeo, Kyung Hae Jung, Yongjun Cha, Sun-Young Kim, Moon Ki Choi, Hee Jin Chang, Seung Myung Dong, Ji Yeon Baek
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 21, Iss 1, Pp 146-155 (2019)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
Aberrant promoter methylation plays a vital role in colorectal carcinogenesis. However, its role in treatment responses is unclear, especially for metastatic disease. Here, we investigated the association between promoter methylation and treatment ou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef1cbf0456599fdf8daa9f9e9cfafef3
http://www.sciencedirect.com/science/article/pii/S147655861830530X
http://www.sciencedirect.com/science/article/pii/S147655861830530X
Autor:
Yasuko eKikuchi, Eiichi eTsuji, Koichi eYagi, Keisuke eMatsusaka, Shingo eTsuji, Junichi eKurebayashi, Toshihisa eOgawa, Hiroyuki eAburatani, Atsushi eKaneda
Publikováno v:
Frontiers in Genetics, Vol 4 (2013)
Cancer arises through accumulation of epigenetic and genetic alteration. Aberrant promoter methylation is a common epigenetic mechanism of gene silencing in cancer cells. We here performed genome-wide analysis of DNA methylation of promoter regions b
Externí odkaz:
https://doaj.org/article/be35db648fed401dae4c290976969dd9
Autor:
David J. Papke, Tomotaka Ugai, Shanshan Shi, Jeffrey A. Meyerhardt, Melissa Zhao, Annacarolina da Silva, Hongmei Nan, Jonathan A. Nowak, Marios Giannakis, Shuji Ogino, Naohiko Akimoto, Tyler S. Twombly, Andrew T. Chan, Xuehong Zhang, Mai Chan Lau, Mingyang Song, Koichiro Haruki, Simeng Gu, Juha P. Väyrynen, Kenji Fujiyoshi, Kota Arima, Jennifer Borowsky, Kana Wu, Jochen K. Lennerz, Junko Kishikawa, Charles S. Fuchs
Publikováno v:
EBioMedicine
EBioMedicine, Vol 57, Iss, Pp 102860-(2020)
EBioMedicine, Vol 57, Iss, Pp 102860-(2020)
Background/Objectives: Tumour budding and poorly differentiated clusters (PDC) represent forms of tumour invasion. We hypothesised that T-cell densities (reflecting adaptive anti-tumour immunity) might be inversely associated with tumour budding and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efa593303ac10de1b212634b5ae5e126
http://europepmc.org/articles/PMC7347996
http://europepmc.org/articles/PMC7347996
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 9, Pp 943-950 (2018)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
There are a substantial portion of colorectal cancers (CRCs), termed interval CRCs (I-CRCs), that are diagnosed shortly after a negative colonoscopy (i.e., no detectable polyps or CRC) and before recommended follow-up screening. The underlying cause(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75dda67723f19d1855fba7e45b3b3e0c
https://doi.org/10.1016/j.neo.2018.07.007
https://doi.org/10.1016/j.neo.2018.07.007
Autor:
Stephen J. Meltzer, Xi Liu
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Gastric cancer (GC) remains the third most common cause of cancer death worldwide, with limited therapeutic strategies available. With the advent of next-generation sequencing and new preclinical model technologies, our understanding of its pathogene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::950b09a9649220690e021736986bdf1f
https://doi.org/10.1016/j.jcmgh.2017.02.003
https://doi.org/10.1016/j.jcmgh.2017.02.003
Autor:
Arriba, María, García, Juan L., Rueda, Daniel, Pérez, Jessica, Brandariz, Lorena, Nutu, Oana A., Alonso, Laura, Rodríguez, Yolanda, Urioste, Miguel, González-Sarmiento, Rogelio, Perea, José
Publikováno v:
Neoplasia (New York, N.Y.)
AIM: To investigate whether chromosomal instability (CIN) is associated with tumor phenotypes and/or with global genomic status based on MSI (microsatellite instability) and CIMP (CpG island methylator phenotype) in early-onset colorectal cancer (EOC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b151cd45cbf4f266206d13112ed5ec4b
http://europepmc.org/articles/PMC5166699
http://europepmc.org/articles/PMC5166699
Autor:
Matthew D. Stachler
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and molecular gastroenterology and hepatology, vol 8, iss 2
Cellular and molecular gastroenterology and hepatology, vol 8, iss 2
Background & Aims Colorectal cancer is an epigenetically heterogeneous disease, however, the extent and spectrum of the CpG island methylator phenotype (CIMP) is not clear. Methods Genome-scale methylation and transcript expression were measured by D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::186f76e85935ebc574906565909230ab
http://europepmc.org/articles/PMC6717931
http://europepmc.org/articles/PMC6717931
Autor:
Larisa M. Haupt, Emily T. Camilleri, Rodney A. Lea, Lyn R. Griffiths, Heidi G. Sutherland, Gabrielle Bradshaw
Publikováno v:
Meta Gene
The methylenetetrahydrofolate reductase (MTHFR) gene codes for the MTHFR enzyme which plays a key role in the pathway of folate and methionine metabolism. Polymorphisms of genes in this pathway affect its regulation and have been linked to lymphoma.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::433215d47696f1c33e815a99db0f7f08
https://doi.org/10.1016/j.mgene.2015.09.004
https://doi.org/10.1016/j.mgene.2015.09.004