Zobrazeno 1 - 10
of 4 482
pro vyhledávání: '"CILIOGENESIS"'
Publikováno v:
Translational Neuroscience, Vol 15, Iss 1, Pp 2623-40 (2024)
This study aimed to elucidate the impact of the TTBK2 T3290C mutation (MUT) associated with Spinocerebellar Ataxia 11 (SCA11) on TTBK2 expression, function, and ciliogenesis. Lymphocytes were isolated from peripheral blood samples of SCA11 family me
Externí odkaz:
https://doaj.org/article/c2acbc2ada314a81993f7c1e2a662fa0
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-13 (2024)
Abstract Background Primary cilia on the surface of eukaryotic cells serve as sensory antennas for the reception and transmission in various cell signaling pathways. They are dynamic organelles that rapidly form during differentiation and cell cycle
Externí odkaz:
https://doaj.org/article/bc815ca100d24104aae14ad3b7c7cb0a
Autor:
Xiaodong Li, Chuanyuan Mao, Guantong Sun, Chen Zhao, Jingjing Dai, Fei Yang, Lei Wang, Xiaoqing Wang
Publikováno v:
View, Vol 5, Iss 4, Pp n/a-n/a (2024)
Abstract The lack of a cure for osteoarthritis (OA), a prevalent joint disease among older individuals, remains an ongoing challenge. Obesity is a common risk factor for OA. Chondrocyte autophagy plays a crucial role in delaying the onset of OA. Our
Externí odkaz:
https://doaj.org/article/69b619a1cce9458fa06cbeef446ac6a0
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 7 (2024)
Externí odkaz:
https://doaj.org/article/2552e55609d44f88920526ff4f1c8c6e
Autor:
Wallace F. Marshall
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
The unicellular green alga, Chlamydomonas reinhardtii, has played a central role in discovering much of what is currently known about the composition, assembly, and function of cilia and flagella. Chlamydomonas combines excellent genetics, such as th
Externí odkaz:
https://doaj.org/article/6715ca6894f8401d98b04f771bdd2f22
Autor:
Shiqi Xie, Xiaoyong Xie, Jing Tang, Biao Luo, Jian Chen, Qixin Wen, Jianrong Zhou, Guojun Chen
Publikováno v:
Genes and Diseases, Vol 11, Iss 3, Pp 101009- (2024)
Furin is a pro-protein convertase that moves between the trans-Golgi network and cell surface in the secretory pathway. We have previously reported that cerebral overexpression of furin promotes cognitive functions in mice. Here, by generating the br
Externí odkaz:
https://doaj.org/article/f82021dab071407f9faaf792fc01737d
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
The heterodimeric kinesin-2 motor (KIF3A/KIF3B with accessory protein KAP3) drives intraflagellar transport, essential for ciliogenesis and ciliary function. Three point mutations in the KIF3B subunit have recently been linked to disease in humans (E
Externí odkaz:
https://doaj.org/article/3b8534b4fd604a7f98f1e6e92fa0e53a
Autor:
Raymond G. Flax, Peter Rosston, Cecilia Rocha, Brian Anderson, Jacob L. Capener, Thomas M. Durcan, David H. Drewry, Panagiotis Prinos, Alison D. Axtman
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Cilia are cellular signaling hubs. Given that human kinases are central regulators of signaling, it is not surprising that kinases are key players in cilia biology. In fact, many kinases modulate ciliogenesis, which is the generation of cilia, and di
Externí odkaz:
https://doaj.org/article/075eef47e68a4433b9e2079571529b77
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Background The cilia are microtubule-based organelles that protrude from the cell surface. Abnormalities in cilia result in various ciliopathies, including polycystic kidney disease (PKD), Bardet-Biedl syndrome (BBS), and oral-facial-digital
Externí odkaz:
https://doaj.org/article/c2e0c25882fb487ebb44847bcb0b9d03
Autor:
Li-Qin Lin, Hai-Kang Zeng, Yu-Long Luo, Di-Fei Chen, Xiao-Qian Ma, Huan-Jie Chen, Xin-Yu Song, Hong-Kai Wu, Shi-Yue Li
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-14 (2023)
Abstract Background Airway basal stem cells (ABSCs) have self-renewal and differentiation abilities. Although an abnormal mechanical environment related to chronic airway disease (CAD) can cause ABSC dysfunction, it remains unclear how mechanical str
Externí odkaz:
https://doaj.org/article/89a10a41adf14d13bb382e460cedca20