Chronic and Latent Viral Infections and Leukocyte Telomere Length across the Lifespan of Female and Male Individuals Living with or without HIV

Autor: Nancy Yi Yang, Anthony Y. Y. Hsieh, Zhuo Chen, Amber R. Campbell, Izabella Gadawska, Fatima Kakkar, Laura Sauve, Ari Bitnun, Jason Brophy, Melanie C. M. Murray, Neora Pick, Mel Krajden, Hélène C. F. Côté, CIHR Team on Cellular Aging and HIV Comorbidities in Women and Children (CARMA)

Publikováno v: Viruses, Vol 16, Iss 5, p 755 (2024)

Background: Chronic/latent viral infections may accelerate immunological aging, particularly among people living with HIV (PLWH). We characterized chronic/latent virus infections across their lifespan and investigated their associations with leukocyt

Externí odkaz: https://doaj.org/article/f1729c1c030944f4b2ad0bda95dd641c

Dynamics of leukocyte telomere length in pregnant women living with HIV, and HIV-negative pregnant women: A longitudinal observational study.

Autor: Sara Saberi, Steve E Kalloger, Mayanne M T Zhu, Beheroze Sattha, Evelyn J Maan, Julianne van Schalkwyk, Deborah M Money, Hélène C F Côté, CIHR Team in Cellular Aging and HIV Comorbidities in Women and Children (CARMA)

Publikováno v: PLoS ONE, Vol 14, Iss 3, p e0212273 (2019)

BACKGROUND:HIV-mediated inflammation and immune activation can accelerate telomere attrition. In addition, antiretrovirals can inhibit telomerase, possibly shortening telomeres. We examined the longitudinal dynamics of leukocyte telomere length (LTL)

Externí odkaz: https://doaj.org/article/9fdb4b1bd0e14fe48842eccea22dff8f

Chronic and Latent Viral Infections and Leukocyte Telomere Length across the Lifespan of Female and Male Individuals Living with or without HIV.

Autor: Yang NY; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 1Z7, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC V6T 1Z4, Canada., Hsieh AYY; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 1Z7, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC V6T 1Z4, Canada., Chen Z; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC V6T 2A1, Canada., Campbell AR; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 1Z7, Canada.; Women's Health Research Institute, British Columbia Women's Hospital and Health Centre, Vancouver, BC V6H 2N9, Canada.; Oak Tree Clinic, BC Women's Hospital and Health Centre, Vancouver, BC V5Z 0C9, Canada., Gadawska I; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 1Z7, Canada., Kakkar F; Department of Pediatrics, CHU Sainte-Justine, Université de Montréal, Montreal, QC H3T 1C5, Canada., Sauve L; Women's Health Research Institute, British Columbia Women's Hospital and Health Centre, Vancouver, BC V6H 2N9, Canada.; Oak Tree Clinic, BC Women's Hospital and Health Centre, Vancouver, BC V5Z 0C9, Canada.; Department of Pediatrics, University of British Columbia, Vancouver, BC V6H 3V4, Canada., Bitnun A; Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, ON M5G 1X8, Canada., Brophy J; Department of Pediatrics, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON K1H 8L1, Canada., Murray MCM; Women's Health Research Institute, British Columbia Women's Hospital and Health Centre, Vancouver, BC V6H 2N9, Canada.; Oak Tree Clinic, BC Women's Hospital and Health Centre, Vancouver, BC V5Z 0C9, Canada.; Department of Medicine, Division of Infectious Diseases, University of British Columbia Faculty of Medicine, Vancouver, BC V5Z 1M9, Canada., Pick N; Women's Health Research Institute, British Columbia Women's Hospital and Health Centre, Vancouver, BC V6H 2N9, Canada.; Oak Tree Clinic, BC Women's Hospital and Health Centre, Vancouver, BC V5Z 0C9, Canada.; Department of Medicine, Division of Infectious Diseases, University of British Columbia Faculty of Medicine, Vancouver, BC V5Z 1M9, Canada., Krajden M; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 1Z7, Canada.; British Columbia Center for Disease Control, Vancouver, BC V5Z 4R4, Canada., Côté HCF; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 1Z7, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.; Women's Health Research Institute, British Columbia Women's Hospital and Health Centre, Vancouver, BC V6H 2N9, Canada., Cihr Team On Cellular Aging And Hiv Comorbidities In Women And Children Carma

Publikováno v: Viruses [Viruses] 2024 May 10; Vol. 16 (5). Date of Electronic Publication: 2024 May 10.