Zobrazeno 1 - 10
of 129
pro vyhledávání: '"CI-988"'
Publikováno v:
Neuroscience Letters. 462:303-307
In the present study we determined whether spinal cholecystokinin (CCK) or the cholecystokinin receptor is involved in below-level neuropathic pain of spinal cord injury (SCI). The effect of the CCK(B) receptor antagonist, CI-988 on mechanical allody
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c6eda6dfca00c2b1d13be8b9b24476a
https://doi.org/10.1016/j.neulet.2009.07.042
https://doi.org/10.1016/j.neulet.2009.07.042
Publikováno v:
Molecular Psychiatry. 13:1079-1092
Cholecystokinin (CCK) involvement in depression-like disorders is poorly documented. Here, we investigated whether CCKergic neurotransmission is relevant to depressive-like symptoms and antidepressant therapy using a novel preclinical model based on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8e3f967d9289117a537bace69a643df
https://doi.org/10.1038/sj.mp.4002097
https://doi.org/10.1038/sj.mp.4002097
Autor:
Andrew J Lawrence, Daniel J. Lodge
Publikováno v:
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 27:451-458
There is a vast literature examining the neurochemical effects of anxiolytics throughout the rat brain; however, although the behavioural actions of anxiolytic drugs are routinely assessed in animal models of anxiety, the majority of neurochemical st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed1eb5bddffa6faac71944f42a940bfa
https://doi.org/10.1016/s0278-5846(03)00032-0
https://doi.org/10.1016/s0278-5846(03)00032-0
Autor:
Rafael Maldonado, Marie Claude Fournie-Zaluski, Robert David Edmund Sewell, Bernard P. Roques, Fazal Subhan, Daniel M. Hutcheson, David Pache
Publikováno v:
European Journal of Pharmacology. 401:197-204
The systemically active mixed inhibitor of enkephalin metabolism, N-((S)-2-benzyl-3[(S) 2-amino-4-methylthio)butyldithio-]-1-oxopropyl)-L-alanine benzylester (RB 120), alone or in combination with 4-¿[2-[[3-(1H-indol-3-yl))-2-methyl-1-oxo-2-[[(tricy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5df72d9bedaf7dd7798e8cf9695dc6df
https://doi.org/10.1016/s0014-2999(00)00441-6
https://doi.org/10.1016/s0014-2999(00)00441-6
Publikováno v:
European Journal of Pharmacology. 390:137-143
The ability of the selective serotonin reuptake inhibitor, fluoxetine, to modify the effects of morphine, N-((S)-2-benzyl-3[(S) 2-amino-4-methylthio)butyldithio-]-1-oxopropyl)-L-alanine benzylester (RB 120; mixed inhibitor of enkephalin metabolism),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a12e6991cfd3da7abd87d275a7b3069
https://doi.org/10.1016/s0014-2999(99)00909-7
https://doi.org/10.1016/s0014-2999(99)00909-7
Publikováno v:
Toxicologic Pathology. 25:441-448
Gastric effects of subchronic treatment with the cholecystokinin-B (CCK-B)/gastrin receptor antagonist CI-988 were investigated in cynomolgus monkeys. In preliminary range-finding studies, CI-988 was given orally to 1 monkey per sex for 14 days at do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e535a73ddecd12bb5c301e6084413ad
https://doi.org/10.1177/019262339702500502
https://doi.org/10.1177/019262339702500502
Autor:
N. Suman-Chauhan, Louise Webdale, Bharat K. Trivedi, Terri S. Purchase, Bruce D. Roth, Bradley Dean Tait, Michael W. Wilson, C.E. Augelli-Szafran
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2009-2014
Due to the interesting pharmacological activity observed for CI-988, a potent and selective CCK-B receptor antagonist, we have continued to study the SAR of this antagonist. This particular study examines the importance of the indole moiety for bindi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5886e2071e1eb3e3a190e66876eee38b
https://doi.org/10.1016/s0960-894x(97)00356-9
https://doi.org/10.1016/s0960-894x(97)00356-9
Publikováno v:
Neuropeptides. 31:287-291
The effects of RB 101 {N-[(R,S)-2-benzyl-3[(S)(2-amino-4-methylthio)butyl dithio]-1-oxo-propyl]-L-phenylalanine benzyl ester}, a complete inhibitor of enkephalin-degrading enzymes and CI 988, a selective antagonist of the cholecystokinin (CCK)-B rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95f782e0afebb79bf7b831338ac64cb5
https://doi.org/10.1016/s0143-4179(97)90061-5
https://doi.org/10.1016/s0143-4179(97)90061-5
Publikováno v:
Psychopharmacology. 129(3):243-248
The effects of the cholecystokinin-B (CCK-B) receptor antagonist CI-988 on symptoms elicited by the cholecystokinin tetrapeptide (CCK4) were studied in DSM-IIIR patients with panic disorder. The study employed a double-blind, two-period incomplete bl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dris___00893::8671150049209399022f5d04044463ef
https://hdl.handle.net/11370/601c20b1-8379-44ad-98b3-3197205965a7
https://hdl.handle.net/11370/601c20b1-8379-44ad-98b3-3197205965a7
Publikováno v:
European Journal of Pharmacology. 312:153-161
This study uses immediate early transcription factor gene expression to map neuronal activation after a single exposure to the elevated X-maze. Exposure to this novel environment leads to widespread upregulation in the gene expression of c-fos, NGFI-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e67df271333d2e5469ddf6be882578ac
https://doi.org/10.1016/0014-2999(96)00471-2
https://doi.org/10.1016/0014-2999(96)00471-2