Phosphorylation of T897 in the dimerization domain of Gemin5 modulates protein interactions and translation regulation

Autor: Rosario Francisco-Velilla, Azman Embarc-Buh, Salvador Abellan, Francisco del Caño-Ochoa, Santiago Ramón-Maiques, Encarnacion Martinez-Salas

Publikováno v: Computational and Structural Biotechnology Journal. 20:6182-6191

10 páginas, 7 figuras
Gemin5 is a multifunctional RNA binding protein (RBP) organized in domains with a distinctive structural organization. The protein is a hub for several protein networks performing diverse RNA-dependent functions including

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8652d46d882bca23b654b6376c05d46
https://doi.org/10.1016/j.csbj.2022.11.018

Tubeimoside-1 induces TFEB-dependent lysosomal degradation of PD-L1 and promotes antitumor immunity by targeting mTOR

Autor: Mingxiao Yin, Xiaojia Liu, Na Zhang, Genxiang Mao, Lu Liu, Hongbin Deng, Peng Yang, Wenjian Min, Kuang Ze'an, Jingwen Dong

Publikováno v: Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 3134-3149 (2021)
Acta Pharmaceutica Sinica. B

Programmed cell death ligand 1 (PD-L1)/programmed cell death protein 1 (PD-1) cascade is an effective therapeutic target for immune checkpoint blockade (ICB) therapy. Targeting PD-L1/PD-1 axis by small-molecule drug is an attractive approach to enhan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71d344df92d314f733377ab3c9584020
http://www.sciencedirect.com/science/article/pii/S2211383521001118

MET inhibition downregulates DR4 expression in MET-amplified lung cancer cells with acquired resistance to EGFR inhibitors through suppressing AP-1-mediated transcription

Autor: Karin A. Vallega, Shuo Zhang, Puyu Shi, Shi-Yong Sun, Liang Deng

Publikováno v: Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 8, Pp 766-774 (2021)

Death receptor 4 (DR4) is a cell surface protein that is generally thought to mediate apoptosis upon binding to its ligand named TRAIL. However, its contribution to apoptosis resistance has also been reported. MET (or c-MET) gene amplification repres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6e6a057877b0a1f933980bc065e9a2d
https://doi.org/10.1016/j.neo.2021.06.006

IκB kinase-ε-mediated phosphorylation triggers IRF-1 degradation in breast cancer cells

Autor: Marta Acchioni, Anna Lisa Remoli, Angela Battistini, Robert Clarke, Chiara Acchioni, Giulia Marsili, Roberto Orsatti, Edvige Perrotti, Marco Sgarbanti

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 10, Pp 459-469 (2020)
Neoplasia (New York, N.Y.)

Interferon Regulatory Factors (IRFs) are key regulators of immunity, cell survival and apoptosis. IRF transcriptional activity and subcellular localization are tightly regulated by posttranscriptional modifications including phosphorylation. The IκB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90dc31ce8201d10ab9e5e10769229024
http://www.sciencedirect.com/science/article/pii/S1476558620301354

Asparagine Synthetase Is Highly Expressed at Baseline in the Pancreas Through Heightened PERK Signaling

Autor: Amitava Mukherjee, Rita Bottino, Nayyar Ahmed, Abraheem N. Ahmad, Michael S. Kilberg, Li Wen, Tanveer A. Javed, Xiangwei Xiao, Fateema T. Rose, Sohail Z. Husain

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 1, Pp 1-13 (2020)
Cellular and Molecular Gastroenterology and Hepatology

Asparaginase (ASNase) causes pancreatitis in approximately 10% of leukemia patients, and the mechanisms underlying this painful complication are not known. ASNase primarily depletes circulating asparagine, and the endogenously expressed enzyme, aspar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45b69cb5fb3be3dbac1c8790abb38907
https://doi.org/10.1016/j.jcmgh.2019.08.003