Zobrazeno 1 - 10
of 252
pro vyhledávání: '"CHUNLIANG LI"'
Publikováno v:
BMC Infectious Diseases, Vol 24, Iss 1, Pp 1-7 (2024)
Abstract Background Cystic echinococcosis (CE) is prevalent in livestock farming regions around the world. However, it remains relatively rare compared to other infectious diseases. CE typically affects the liver, lungs, brain, and kidneys. Spinal an
Externí odkaz:
https://doaj.org/article/cc1a153b94464b32afc7b34946dff42f
Autor:
Mengli Zhang, Judith Hyle, Xiaowen Chen, Ye Xin, Yingcai Jin, Jianxiang Zhang, Xue Yang, Xinfeng Chen, Shaela Wright, Zhenling Liu, Wojciech Rosikiewicz, Beisi Xu, Liusheng He, Hong Liu, Nana Ping, Depei Wu, Feiqiu Wen, Chunliang Li, Peng Xu
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-29 (2024)
Abstract Background The oncogenic protein HOXA9 plays a critical role in leukemia transformation and maintenance, and its aberrant expression is a hallmark of most aggressive acute leukemia. Although inhibiting the upstream regulators of HOXA9 has be
Externí odkaz:
https://doaj.org/article/26d5519bd45f4d089483909374e268f8
Autor:
Shaela Wright, Xujie Zhao, Wojciech Rosikiewicz, Shelby Mryncza, Judith Hyle, Wenjie Qi, Zhenling Liu, Siqi Yi, Yong Cheng, Beisi Xu, Chunliang Li
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Accumulating evidence indicates that HOXA9 dysregulation is necessary and sufficient for leukemic transformation and maintenance. However, it remains largely unknown how HOXA9, as a homeobox transcriptional factor, binds to noncoding regulat
Externí odkaz:
https://doaj.org/article/471e2ddbee5c446b898b4a5cbf5a07c6
Publikováno v:
Metals, Vol 14, Iss 7, p 779 (2024)
In this study, the molecular dynamics (MD) method was used to study the tensile deformation of polycrystalline γ-TiAl with complex and random grain orientations. Firstly, the tensile deformation was simulated with different average grain sizes (8.60
Externí odkaz:
https://doaj.org/article/dd3fdfed7bec4d4ea5eb0e2a876ba52a
Autor:
Heting Wang, Xuya Pan, Xiaoxin Xiang, Yang Zhang, Jianning Chen, Shiyi Wen, Jin Wang, Rong Gao, Jifeng Yang, Yaping Zhi, Siying Wen, Yubao Zheng, Ting Li, Heying Ai, Xuemin He, Yan Lu, Yanhua Zhu, Chunliang Li, Yanming Chen, Guojun Shi
Publikováno v:
Cell Death and Disease, Vol 14, Iss 8, Pp 1-12 (2023)
Abstract Unfolded protein response (UPR) maintains the endoplasmic reticulum (ER) homeostasis, survival, and physiological function of mammalian cells. However, how cells adapt to ER stress under physiological or disease settings remains largely uncl
Externí odkaz:
https://doaj.org/article/80c25923ef96473abc528f19e8c7dc70
Autor:
Judith Hyle, Mohamed Nadhir Djekidel, Justin Williams, Shaela Wright, Ying Shao, Beisi Xu, Chunliang Li
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-30 (2023)
Abstract Background CTCF is a well-established chromatin architectural protein that also plays various roles in transcriptional regulation. While CTCF biology has been extensively studied, how the domains of CTCF function to regulate transcription re
Externí odkaz:
https://doaj.org/article/653df8a9744f4e94aef44191fad0d353
Publikováno v:
Journal of Orthopaedic Surgery and Research, Vol 17, Iss 1, Pp 1-16 (2022)
Abstract Background Osteoarthritis (OA) is a chronic degenerative disease that is one of the main causes of disability in middle-aged and elderly people. Adipose stem cell (ASC)-derived exosomes (ASC-Exo) could repair cartilage damage and treat OA. M
Externí odkaz:
https://doaj.org/article/5f5848b4fdca464f9dfc69903e0f1280
Autor:
Beisi Xu, Hong Wang, Shaela Wright, Judith Hyle, Yang Zhang, Ying Shao, Mingming Niu, Yiping Fan, Wojciech Rosikiewicz, Mohamed Nadhir Djekidel, Junmin Peng, Rui Lu, Chunliang Li
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-25 (2021)
Abstract Background The transcription factor CTCF appears indispensable in defining topologically associated domain boundaries and maintaining chromatin loop structures within these domains, supported by numerous functional studies. However, acute de
Externí odkaz:
https://doaj.org/article/3af666db8ed9486ba062ca3e3c397961
Autor:
Justin Williams, Beisi Xu, Daniel Putnam, Andrew Thrasher, Chunliang Li, Jun Yang, Xiang Chen
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-27 (2021)
Abstract Although genome-wide DNA methylomes have demonstrated their clinical value as reliable biomarkers for tumor detection, subtyping, and classification, their direct biological impacts at the individual gene level remain elusive. Here we presen
Externí odkaz:
https://doaj.org/article/07f7d1b6e24d458898b48408a66b8c26
Autor:
Chuanhu Chen, Chunliang Li
Publikováno v:
IEEE Access, Vol 9, Pp 7723-7731 (2021)
Many process synthesis and design problems in engineering are actually mixed integer nonlinear programming problems (MINLP), because they contain both continuous and integer variables. These problems are generally recognized to be complex and intract
Externí odkaz:
https://doaj.org/article/516890b3b60e4c6db94cd7a5af3342fc