Zobrazeno 1 - 10
of 52
pro vyhledávání: '"CHUN, YAN REN"'
Autor:
Fan-Sheng Kong, Junjie Feng, Jin-Ping Yao, Yinghua Lu, Tao Guo, Meng Sun, Chun-Yan Ren, Yun-Yun Jin, Yaping Ma, Jian-Huan Chen
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-20 (2024)
Abstract Background Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder affecting women of reproductive ages. Our previous study has implicated a possible link between RNA editing and PCOS, yet the actual role of RNA editing, its assoc
Externí odkaz:
https://doaj.org/article/88eae5c60c8a42eabd30b8058cdfe7fe
Engineered CBEs based on Macaca fascicularis A3A with improved properties for precise genome editing
Autor:
Chun-Yan Ren, Yan-Shan Liu, Yu-Shan He, Lin-Pei Zhang, Jun-Hua Rao, Yijian Rao, Jian-Huan Chen
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113878- (2024)
Summary: Cytidine deaminase defines the properties of cytosine base editors (CBEs) for C-to-T conversion. Replacing the cytidine deaminase rat APOBEC1 (rA1) in CBEs with a human APOBEC3A (hA3A) improves CBE properties. However, the potential CBE appl
Externí odkaz:
https://doaj.org/article/649db4d3376b4527a6c7b19ff185ffe3
Publikováno v:
BMC Medical Genomics, Vol 16, Iss 1, Pp 1-13 (2023)
Abstract Background Solute Carrier Family 31 Member 1 (SLC31A1) has recently been identified as a cuproptosis-regulatory gene. Recent studies have indicated that SLC31A1 may play a role in colorectal and lung cancer tumorigenesis. However, the role o
Externí odkaz:
https://doaj.org/article/7118e598c9e24a74ac63bf662e717973
Autor:
Fan-Sheng Kong, Zijing Lu, Yuan Zhou, Yinghua Lu, Chun-Yan Ren, Ruofan Jia, Beilei Zeng, Panwang Huang, Jihong Wang, Yaping Ma, Jian-Huan Chen
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
BackgroundPolycystic ovary syndrome (PCOS) is a complex, multifactor disorder in women of reproductive age worldwide. Although RNA editing may contribute to a variety of diseases, its role in PCOS remains unclear.MethodsA discovery RNA-Seq dataset wa
Externí odkaz:
https://doaj.org/article/00313ca40ae149efb708960ac26d3c08
Autor:
Fu-Xia Ru, Fanzhi Kong, Chun-Yan Ren, Yu-Shan He, Shou-Yue Xia, Yu-Ning Li, Ya-Ping Liang, Jun-Jie Feng, Zhi-Yuan Wei, Jian-Huan Chen
Publikováno v:
Frontiers in Psychiatry, Vol 13 (2022)
Winner-loser effects influence subsequent agonistic interactions between conspecifics. Previous winning experiences could strengthen future aggression and increase the chance of winning the next agonistic interaction, while previous losing experience
Externí odkaz:
https://doaj.org/article/48bd27a8776e4d4997bcdce71f20d9ac
Autor:
Jing-Qian Zhang, Jia-Qi Pan, Zhi-Yuan Wei, Chun-Yan Ren, Fu-Xia Ru, Shou-Yue Xia, Yu-Shan He, Kaisheng Lin, Jian-Huan Chen
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Recent studies suggest that RNA editing is associated with impaired brain function and neurological and psychiatric disorders. However, the role of A-to-I RNA editing during sepsis-associated encephalopathy (SAE) remains unclear. In this study, we an
Externí odkaz:
https://doaj.org/article/ea22009a96594e7aa6857d8636495348
Autor:
Jiali Zhang, Ji Tao, Ruo-Nan Gao, Zhi-Yuan Wei, Yu-Shan He, Chun-Yan Ren, Qi-Chun Li, Yan-Shan Liu, Ke-Wei Wang, Gong Yang, Chengjia Qian, Jian-Huan Chen
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The involvement of gut microbiota in T-cell trafficking into tumor tissue of colorectal cancer (CRC) remains to be further elucidated. The current study aimed to evaluate the expression of major cytotoxic T-cell trafficking chemokines (CTTCs) and che
Externí odkaz:
https://doaj.org/article/c06b04db376347a496aff85b9bd1af21
Transcriptome-Wide Identification of G-to-A RNA Editing in Chronic Social Defeat Stress Mouse Models
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Emerging evidence suggests that RNA editing is associated with stress, neurological diseases, and psychiatric disorders. However, the role of G-to-A RNA editing in chronic social defeat stress (CSDS) remains unclear. We herein identified G-to-A RNA e
Externí odkaz:
https://doaj.org/article/b698033e83d842b3b2578090cc7ef567
Autor:
Fan-Sheng Kong, Yuan Zhou, Yinghua Lu, Chun-Yan Ren, Min Chen, Ruofan Jia, Jian-Huan Chen, Yaping Ma
Background Polycystic ovary syndrome (PCOS) is a common female endocrinal disease that may result in excessive androgen, but the mechanism of PCOS remains unclear. Most patients with PCOS suffer from low-grade inflammation, whereas the underlying con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7c2e2bad189a1032c58559d2d600fbf
https://doi.org/10.21203/rs.3.rs-2083076/v1
https://doi.org/10.21203/rs.3.rs-2083076/v1
Autor:
Ping Hou, Ji-Feng Wan, Yan-Shan Liu, Jian-Huan Chen, En-Min Li, Qian-Hao Yao, Jia-Qi Pan, Shao-Qiang Liu, Jia-Li Zhang, Ruo-Nan Gao, Zhou-Heng Xu, Ji-Hong Wang, Jun-Hua Rao, Xu-Bin Pan, Chun-Yan Ren
Publikováno v:
Biochemical and Biophysical Research Communications. 531:172-179
Mutations in the retinitis pigmentosa GTPase regulator (RPGR) gene, are the major cause of X-linked retinitis pigmentosa (RP), in which exon open reading frame 15 (ORF15) of RPGR has been implicated to play a substantial role. We identified a novel h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a75c063039bf48d99a73eacbaab06453
https://doi.org/10.1016/j.bbrc.2020.06.109
https://doi.org/10.1016/j.bbrc.2020.06.109