Potential immunologic and prognostic roles of CHRNA6 in SCLC and pan-cancer

Autor: Qingqing Zhao, Cong Wang, Wucui Huang, Zhongquan Song, Yang Lang, Xiaoli Zhu

Publikováno v: Heliyon, Vol 10, Iss 19, Pp e38572- (2024)

Background: Small cell lung cancer (SCLC) is considered the most malignant subtype of lung cancer, and it has a restricted range of therapeutic choices. The emergence of immunotherapy has offered new possibilities for patients with SCLC. However, the

Externí odkaz: https://doaj.org/article/2bbe08c1d4c341e6a5d416d208258671

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Co-occurring WARS2 and CHRNA6 mutations in a child with a severe form of infantile parkinsonism

Autor: Flavia Trettel, Cristina Roseti, Rosalba Carrozzo, Teresa Rizza, Susanna Cogo, Anna Rita Bentivoglio, Claudia Carducci, Cristina Limatola, Alice Traversa, Gianfranco Bocchinfuso, Martina Venditti, Laura Civiero, Michela Di Nottia, Viviana Caputo, Eleonora Palma, Miriam Sciaccaluga, Ambra Lanzo, Maria Paglione, Luca Pannone, Manju A. Kurian, Serena Galosi, Simone Martinelli, Vincenzo Leuzzi, Lorenzo Stella, A Farrotti, Sergio Fucile, Laura Bernardini, Viviana Cordeddu, Joanne Ng, Marco Tartaglia, Elia Di Schiavi, Elisa Greggio, Andrea Ciolfi

Publikováno v: Parkinsonism & related disorders 72 (2020): 75–79. doi:10.1016/j.parkreldis.2020.02.003
info:cnr-pdr/source/autori:Martinelli, Simone; Cordeddu, Viviana; Galosi, Serena; Lanzo, Ambra; Palma, Eleonora; Pannone, Luca; Ciolfi, Andrea; Di Nottia, Michela; Rizza, Teresa; Bocchinfuso, Gianfranco; Traversa, Alice; Caputo, Viviana; Farrotti, Andrea; Carducci, Claudia; Bernardini, Laura; Cogo, Susanna; Paglione, Maria; Venditti, Martina; Bentivoglio, Annarita; Ng, Joanne; Kurian, Manju A.; Civiero, Laura; Greggio, Elisa; Stella, Lorenzo; Trettel, Flavia; Sciaccaluga, Miriam; Roseti, Cristina; Carrozzo, Rosalba; Fucile, Sergio; Limatola, Cristina; Di Schiavi, Elia; Tartaglia, Marco; Leuzzi, Vincenzo/titolo:Co-occurring WARS2 and CHRNA6 mutations in a child with a severe form of infantile parkinsonism/doi:10.1016%2Fj.parkreldis.2020.02.003/rivista:Parkinsonism & related disorders/anno:2020/pagina_da:75/pagina_a:79/intervallo_pagine:75–79/volume:72

Objective To investigate the molecular cause(s) underlying a severe form of infantile-onset parkinsonism and characterize functionally the identified variants. Methods A trio-based whole exome sequencing (WES) approach was used to identify the candid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e750dcab6b5e7a1b6ab8d5c5c98db0a
https://doi.org/10.1016/j.parkreldis.2020.02.003

Bidirectional sex-dependent regulation of α6 and β3 nicotinic acetylcholine receptors by protein kinase Cε

Autor: Kevin Wickman, Janna K. Moen, Anna M. Lee, Julia E Myjack, Margot C. DeBaker

Publikováno v: Addict Biol

Nicotine and alcohol are the most commonly abused substances worldwide, and comorbid nicotine and alcohol addiction is highly prevalent. Nicotinic acetylcholine receptors (nAChRs) containing the α6 and β3 subunits are expressed in neural reward cir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dd77b9017b51821c93eb6a6bd3aacc6

α6β2 nicotinic acetylcholine receptors influence locomotor activity and ethanol consumption

Autor: Helen M. Kamens, Alex Gechlik, Akshat Rajan, Caitlin Garrity, Colette Peck, Brenita C. Jenkins

Publikováno v: Alcohol. 61:43-49

Nicotinic acetylcholine receptors (nAChRs) in the mesolimbic dopamine system have been implicated in ethanol behaviors. In particular, work in genetically engineered mice has demonstrated that α6-containing nAChRs are involved in ethanol consumption

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8257f3ec5f73c76e6315725a40184ea6
https://doi.org/10.1016/j.alcohol.2017.02.178