Increased soluble urokinase plasminogen activator levels modulate monocyte function to promote atherosclerosis

Autor: George Hindy, Daniel J. Tyrrell, Alexi Vasbinder, Changli Wei, Feriel Presswalla, Hui Wang, Pennelope Blakely, Ayse Bilge Ozel, Sarah Graham, Grace H. Holton, Joseph Dowsett, Akl C. Fahed, Kingsley-Michael Amadi, Grace K. Erne, Annika Tekmulla, Anis Ismail, Christopher Launius, Nona Sotoodehnia, James S. Pankow, Lise Wegner Thørner, Christian Erikstrup, Ole Birger Pedersen, Karina Banasik, Søren Brunak, Henrik Ullum, Jesper Eugen-Olsen, Sisse Rye Ostrowski, on behalf of the DBDS Consortium, Mary E. Haas, Jonas B. Nielsen, Luca A. Lotta, on behalf of the Regeneron Genetics Center, Gunnar Engström, Olle Melander, Marju Orho-Melander, Lili Zhao, Venkatesh L. Murthy, David J. Pinsky, Cristen J. Willer, Susan R. Heckbert, Jochen Reiser, Daniel R. Goldstein, Karl C. Desch, Salim S. Hayek

Publikováno v: The Journal of Clinical Investigation, Vol 132, Iss 24 (2022)

People with kidney disease are disproportionately affected by atherosclerosis for unclear reasons. Soluble urokinase plasminogen activator receptor (suPAR) is an immune-derived mediator of kidney disease, levels of which are strongly associated with

Externí odkaz: https://doaj.org/article/97725ccf03d44b8f8179f849f6db2e96

Inflammation, Hyperglycemia, and Adverse Outcomes in Individuals With Diabetes Mellitus Hospitalized for COVID-19

Autor: Alexi, Vasbinder, Elizabeth, Anderson, Husam, Shadid, Hanna, Berlin, Michael, Pan, Tariq U, Azam, Ibrahim, Khaleel, Kishan, Padalia, Chelsea, Meloche, Patrick, O'Hayer, Erinleigh, Michaud, Tonimarie, Catalan, Rafey, Feroze, Pennelope, Blakely, Christopher, Launius, Yiyuan, Huang, Lili, Zhao, Lynn, Ang, Monica, Mikhael, Kara, Mizokami-Stout, Subramaniam, Pennathur, Matthias, Kretzler, Sven H, Loosen, Athanasios, Chalkias, Frank, Tacke, Evangelos J, Giamarellos-Bourboulis, Jochen, Reiser, Jesper, Eugen-Olsen, Eva L, Feldman, Rodica, Pop-Busui, Salim S, Hayek, Kishan J, Padalia, Danny, Perry, Abbas, Bitar, Rayan, Kaakati, Beata, Samelko, Alex, Hlepas, Priya P, Patel, Xuexiang, Wang, Izzet, Altintas, Marius, Stauning, Morten, Baltzer Houlind, Mette B, Lindstrøm, Hejdi, Gamst-Jensen, Line Jee, Hartmann, Jan O, Nehlin, Thomas, Kallemose, Imran, Parvaiz, Christian, Rasmussen, Ove, Andersen, Jens, Tingleff, Maria-Evangelia, Adami, Nicky, Solomonidi, Maria, Tsilika, Maria, Saridaki, Vasileios, Lekakis, Tom, Luedde, Verena, Keitel, Eleni, Arnaoutoglou, Ioannis, Pantazopoulos, Eleni, Laou, Konstantina, Kolonia, Anargyros, Skoulakis, Pinkus, Tober-Lau, Raphael, Mohr, Florian, Kurth, Leif Erik, Sander, Christoph, Jochum

Publikováno v: Diabetes Care

OBJECTIVE Diabetes mellitus (DM) is a major risk factor for severe coronavirus disease 2019 (COVID-19) for reasons that are unclear. RESEARCH DESIGN AND METHODS We leveraged the International Study of Inflammation in COVID-19 (ISIC), a multicenter ob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d394bb00ceee56045534fe3df263ccf1
https://doi.org/10.2337/dc21-2102

Inflammation, Hyperglycemia, and Adverse Outcomes in Individuals With Diabetes Mellitus Hospitalized for COVID-19

Autor: the ISIC group, Salim S. Hayek, Rodica Pop-Busui, Eva L. Feldman, Jesper Eugen-Olsen, Jochen Reiser, Evangelos J. Giamarellos-Bourboulis, Frank Tacke, Athanasios Chalkias, Sven H. Loosen, Matthias Kretzler, Subramaniam Pennathur, Kara Mizokami-Stout, Monica Mikhael, Lynn Ang, Lili Zhao, Yiyuan Huang, Christopher Launius, Pennelope Blakely, Rafey Feroze, Tonimarie Catalan, Erinleigh Michaud, Patrick O’Hayer, Chelsea Meloche, Kishan Padalia, Ibrahim Khaleel, Tariq U. Azam, Michael Pan, Hanna Berlin, Husam Shadid, Elizabeth Anderson, Alexi Vasbinder

Objective: Diabetes mellitus (DM) is a major risk factor for severe coronavirus disease 2019 (COVID-19) for reasons that are unclear. Research Design and Methods: We leveraged The International Study of Inflammation in COVID-19, a multicenter observa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e04a9f149fdf0b14b57828c14ee57e5
https://doi.org/10.2337/figshare.17383496

Circulating Osteopontin Levels and Outcomes in Patients Hospitalized for COVID-19

Autor: Loosen, Salim S. Hayek, Christoph Roderburg, Pennelope Blakely, Christopher Launius, Jesper Eugen-Olsen, Frank Tacke, Sofia Ktena, Verena Keitel, Mark Luedde, Evangelos J. Giamarellos-Bourboulis, Tom Luedde, Sven H.

Publikováno v: Journal of Clinical Medicine; Volume 10; Issue 17; Pages: 3907

Background: Severe coronavirus disease 2019 (COVID-19) is the result of a hyper-inflammatory reaction to the severe acute respiratory syndrome coronavirus 2. The biomarkers of inflammation have been used to risk-stratify patients with COVID-19. Osteo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::94f25ce05b9a96def9d046cb18e72f6a

Hospital-Level Variation in Death for Critically Ill Patients with COVID-19

Autor: Matthew M. Churpek, Shruti Gupta, Alexandra B. Spicer, William F. Parker, John Fahrenbach, Samantha K. Brenner, David E. Leaf, Carl P. Walther, Samaya J. Anumudu, Justin Arunthamakun, Kathleen F. Kopecky, Gregory P. Milligan, Peter A. McCullough, Thuy-Duyen Nguyen, Shahzad Shaefi, Megan L. Krajewski, Sidharth Shankar, Ameeka Pannu, Juan D. Valencia, Sushrut S. Waikar, Zoe A. Kibbelaar, Ambarish M. Athavale, Peter Hart, Shristi Upadhyay, Ishaan Vohra, Adam Green, Jean-Sebastien Rachoin, Christa A. Schorr, Lisa Shea, Daniel L. Edmonston, Christopher L. Mosher, Alexandre M. Shehata, Zaza Cohen, Valerie Allusson, Gabriela Bambrick-Santoyo, Noor ul aain Bhatti, Bijal Mehta, Aquino Williams, Patricia Walters, Ronaldo C. Go, Keith M. Rose, Miguel A. Hernán, Lili Chan, Kusum S. Mathews, Steven G. Coca, Deena R. Altman, Aparna Saha, Howard Soh, Huei Hsun Wen, Sonali Bose, Emily A. Leven, Jing G. Wang, Gohar Mosoyan, Girish N. Nadkarni, Pattharawin Pattharanitima, Emily J. Gallagher, Allon N. Friedman, John Guirguis, Rajat Kapoor, Christopher Meshberger, Katherine J. Kelly, Chirag R. Parikh, Brian T. Garibaldi, Celia P. Corona-Villalobos, Yumeng Wen, Steven Menez, Rubab F. Malik, Elena Cervantes, Samir Gautam, Mary C. Mallappallil, Jie Ouyang, Sabu John, Ernie Yap, Yohannes Melaku, Ibrahim Mohamed, Siddartha Bajracharya, Isha Puri, Mariah Thaxton, Jyotsna Bhattacharya, John Wagner, Leon Boudourakis, H. Bryant Nguyen, Afshin Ahoubim, Leslie F. Thomas, Dheeraj Reddy Sirganagari, Pramod K. Guru, Kianoush Kashani, Shahrzad Tehranian, Yan Zhou, Paul A. Bergl, Jesus Rodriguez, Jatan A. Shah, Mrigank S. Gupta, Princy N. Kumar, Deepa G. Lazarous, Seble G. Kassaye, Michal L. Melamed, Tanya S. Johns, Ryan Mocerino, Kalyan Prudhvi, Denzel Zhu, Rebecca V. Levy, Yorg Azzi, Molly Fisher, Milagros Yunes, Kaltrina Sedaliu, Ladan Golestaneh, Maureen Brogan, Neelja Kumar, Michael Chang, Jyotsana Thakkar, Ritesh Raichoudhury, Akshay Athreya, Mohamed Farag, Edward J. Schenck, Soo Jung Cho, Maria Plataki, Sergio L. Alvarez-Mulett, Luis G. Gomez-Escobar, Di Pan, Stefi Lee, Jamuna Krishnan, William Whalen, David Charytan, Ashley Macina, Sobaata Chaudhry, Benjamin Wu, Frank Modersitzki, Anand Srivastava, Alexander S. Leidner, Carlos Martinez, Jacqueline M. Kruser, Richard G. Wunderink, Alexander J. Hodakowski, Juan Carlos Q. Velez, Eboni G. Price-Haywood, Luis A. Matute-Trochez, Anna E. Hasty, Muner M. B. Mohamed, Rupali S. Avasare, David Zonies, Meghan E. Sise, Erik T. Newman, Samah Abu Omar, Kapil K. Pokharel, Shreyak Sharma, Harkarandeep Singh, Simon Correa, Tanveer Shaukat, Omer Kamal, Wei Wang, Heather Yang, Jeffery O. Boateng, Meghan Lee, Ian A. Strohbehn, Jiahua Li, Ariel L. Mueller, Roberta Redfern, Nicholas S. Cairl, Gabriel Naimy, Abeer Abu-Saif, Danyell Hall, Laura Bickley, Chris Rowan, Farah Madhai-Lovely, Vasil Peev, Jochen Reiser, John J. Byun, Andrew Vissing, Esha M. Kapania, Zoe Post, Nilam P. Patel, Joy-Marie Hermes, Anne K. Sutherland, Amee Patrawalla, Diana G. Finkel, Barbara A. Danek, Sowminya Arikapudi, Jeffrey M. Paer, Peter Cangialosi, Mark Liotta, Jared Radbel, Jag Sunderram, Sonika Puri, Jayanth S. Vatson, Matthew T. Scharf, Ayesha Ahmed, Ilya Berim, Shuchi Anand, Joseph E. Levitt, Pablo Garcia, Suzanne M. Boyle, Rui Song, Ali Arif, Jingjing Zhang, Sang Hoon Woo, Xiaoying Deng, Goni Katz-Greenberg, Katharine Senter, Moh’d A. Sharshir, Vadym V. Rusnak, Muhammad Imran Ali, Terri Peters, Kathy Hughes, Anip Bansal, Amber S. Podoll, Michel Chonchol, Sunita Sharma, Ellen L. Burnham, Arash Rashidi, Rana Hejal, Eric Judd, Laura Latta, Ashita Tolwani, Timothy E. Albertson, Jason Y. Adams, Steven Y. Chang, Rebecca M. Beutler, Santa Monica, Carl E. Schulze, Etienne Macedo, Harin Rhee, Kathleen D. Liu, Vasantha K. Jotwani, Jay L. Koyner, Chintan V. Shah, Vishal Jaikaransingh, Stephanie M. Toth-Manikowski, Min J. Joo, James P. Lash, Javier A. Neyra, Nourhan Chaaban, Alfredo Iardino, Elizabeth H. Au, Jill H. Sharma, Marie Anne Sosa, Sabrina Taldone, Gabriel Contreras, David De La Zerda, Alessia Fornoni, Hayley B. Gershengorn, Salim S. Hayek, Pennelope Blakely, Hanna Berlin, Tariq U. Azam, Husam Shadid, Michael Pan, Patrick O’Hayer, Chelsea Meloche, Rafey Feroze, Rayan Kaakati, Danny Perry, Abbas Bitar, Elizabeth Anderson, Kishan J. Padalia, Christopher Launius, John P. Donnelly, Andrew J. Admon, Jennifer E. Flythe, Matthew J. Tugman, Emily H. Chang, Brent R. Brown, Amanda K. Leonberg-Yoo, Ryan C. Spiardi, Todd A. Miano, Meaghan S. Roche, Charles R. Vasquez, Amar D. Bansal, Natalie C. Ernecoff, Sanjana Kapoor, Siddharth Verma, Huiwen Chen, Csaba P. Kovesdy, Miklos Z. Molnar, Ambreen Azhar, S. Susan Hedayati, Mridula V. Nadamuni, Shani Shastri, Duwayne L. Willett, Samuel A. P. Short, Amanda D. Renaghan, Kyle B. Enfield, Pavan K. Bhatraju, A. Bilal Malik, Matthew W. Semler, Anitha Vijayan, Christina Mariyam Joy, Tingting Li, Seth Goldberg, Patricia F. Kao, Greg L. Schumaker, Nitender Goyal, Anthony J. Faugno, Caroline M. Hsu, Asma Tariq, Leah Meyer, Ravi K. Kshirsagar, Daniel E. Weiner, Marta Christov, Jennifer Griffiths, Sanjeev Gupta, Aromma Kapoor, Perry Wilson, Tanima Arora, Ugochukwu Ugwuowo

Publikováno v: American Journal of Respiratory and Critical Care Medicine

Variation in hospital mortality has been described for coronavirus disease 2019 (COVID-19), but the factors that explain these differences remain unclear.Our objective was to utilize a large, nationally representative dataset of critically ill adults

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a4bbe44b873d0916e795c5821fdd14e
https://pubmed.ncbi.nlm.nih.gov/34139143