Zobrazeno 1 - 10
of 124
pro vyhledávání: '"CHONG WEE LIEW"'
Autor:
Marcos David Munoz, Alexa Zamudio, Maximilian McCann, Victoria Gil, Pingwen Xu, Chong Wee Liew
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Long-term ad libitum dietary restrictions, such as low-protein diets (LPDs), improve metabolic health and extend the life span of mice and humans. However, most studies conducted thus far have focused on the preventive effects of LPDs on met
Externí odkaz:
https://doaj.org/article/6a7058b0c2134836a575f2df4e4742bd
Autor:
Xuanchun Wang, Yanliang Li, Guifen Qiang, Kaihua Wang, Jiarong Dai, Maximilian McCann, Marcos D. Munoz, Victoria Gil, Yifei Yu, Shengxian Li, Zhihong Yang, Shanshan Xu, Jose Cordoba-Chacon, Dario F. De Jesus, Bei Sun, Kuangyang Chen, Yahao Wang, Xiaoxia Liu, Qing Miao, Linuo Zhou, Renming Hu, Qiang Ding, Rohit N. Kulkarni, Daming Gao, Matthias Blüher, Chong Wee Liew
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Secreted isoform of endoplasmic reticulum membrane complex subunit 10 (scEMC10) is a secreted protein of incompletely understood physiological function. Here the authors show that scEMC10 is upregulated in people with obesity, and that that genetic E
Externí odkaz:
https://doaj.org/article/5b0502f9dec14a5fa157af171c82f84a
Autor:
Qing Song, Yingli Chen, Qinchao Ding, Alexandra Griffiths, Lifeng Liu, Jooman Park, Chong Wee Liew, Natalia Nieto, Songtao Li, Xiaobing Dou, Yuwei Jiang, Zhenyuan Song
Publikováno v:
Hepatology Communications, Vol 7, Iss 3, Pp e0059-e0059 (2023)
Background:. Adipose tissue thermogenic activities use fatty acids from lipolysis for heat generation. Therefore, a tight coupling between lipolysis and thermogenesis is physiologically imperative in maintaining not only body temperature but also lip
Externí odkaz:
https://doaj.org/article/9120e3e3701f4ff49a33b97a0f6a6ef8
Autor:
Maximilian A. McCann, Yanliang Li, Marcos Muñoz, Victoria Gil, Guifen Qiang, Jose Cordoba-Chacon, Matthias Blüher, Stephen Duncan, Chong Wee Liew
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract We found the hepatic transcription factor Cyclic-AMP Responsive Element Binding Protein 3-like-3 (CREB3L3) to be expressed in adipose tissue, and selectively downregulated in the more metabolically protective subcutaneous adipose tissue in o
Externí odkaz:
https://doaj.org/article/ba282b53acb742e59a203873b579f767
Autor:
Maximilian A. McCann, Yanliang Li, Marcos Muñoz, Victoria Gil, Guifen Qiang, Jose Cordoba-Chacon, Matthias Blüher, Stephen Duncan, Chong Wee Liew
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/86e5731ff9aa4040961b12b17acc568d
Autor:
Guifen Qiang, Hyerim Whang Kong, Shanshan Xu, Hoai An Pham, Sebastian D. Parlee, Aaron A. Burr, Victoria Gil, Jingbo Pang, Amy Hughes, Xuejiang Gu, Giamila Fantuzzi, Ormond A. MacDougald, Chong Wee Liew
Publikováno v:
Molecular Metabolism, Vol 5, Iss 7, Pp 480-490 (2016)
Objective: Insulin signaling plays pivotal roles in the development and metabolism of many tissues and cell types. A previous study demonstrated that ablation of insulin receptor (IR) with aP2-Cre markedly reduced adipose tissues mass and protected m
Externí odkaz:
https://doaj.org/article/6bda484a50044a93b7fa954638b64932
Autor:
Guifen Qiang, Hyerim Whang Kong, Difeng Fang, Maximilian McCann, Xiuying Yang, Guanhua Du, Matthias Blüher, Jinfang Zhu, Chong Wee Liew
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Visceral and subcutaneous fat are associated with different metabolic risk, but mediators of such depot specific effects are not very well known. Here the authors identify the transcriptional regulator, TRIP-Br2, as a regulator of endoplasmic reticul
Externí odkaz:
https://doaj.org/article/d145f4d2d68b4d5c8afc9fb6d1e6e4a0
Autor:
Ping He, Biyu Hou, Yanliang Li, Chunyang Xu, Peng Ma, Sin Man Lam, Victoria Gil, Xinyu Yang, Xiuying Yang, Li Zhang, Guanghou Shui, Junke Song, Guifen Qiang, Chong Wee Liew, Guanhua Du
Publikováno v:
Biomolecules, Vol 9, Iss 9, p 444 (2019)
Background: White adipose tissue (WAT) browning confers beneficial effects on metabolic diseases. However, visceral adipose tissue (VAT) is not as susceptible to browning as subcutaneous adipose tissue (SAT). Aim: Interpreting the heterogeneity of VA
Externí odkaz:
https://doaj.org/article/64c65bdfa3a143e49b091adf4281693d
Autor:
Abdelfattah El Ouaamari, Dan Kawamori, Ercument Dirice, Chong Wee Liew, Jennifer L. Shadrach, Jiang Hu, Hitoshi Katsuta, Jennifer Hollister-Lock, Wei-Jun Qian, Amy J. Wagers, Rohit N. Kulkarni
Publikováno v:
Cell Reports, Vol 3, Iss 2, Pp 401-410 (2013)
Integrative organ crosstalk regulates key aspects of energy homeostasis, and its dysregulation may underlie metabolic disorders such as obesity and diabetes. To test the hypothesis that crosstalk between the liver and pancreatic islets modulates β c
Externí odkaz:
https://doaj.org/article/bf6ed007b2414bab9f248d15d7042116
Autor:
Gamze Kilic, Ana I Alvarez-Mercado, Bader Zarrouki, Darren Opland, Chong Wee Liew, Laura C Alonso, Martin G Myers, Jean-Christophe Jonas, Vincent Poitout, Rohit N Kulkarni, Franck Mauvais-Jarvis
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87941 (2014)
The female steroid, 17β-estradiol (E2), is important for pancreatic β-cell function and acts via at least three estrogen receptors (ER), ERα, ERβ, and the G-protein coupled ER (GPER). Using a pancreas-specific ERα knockout mouse generated using
Externí odkaz:
https://doaj.org/article/ed2b0ea788fa41138aad1bca00fcc666