Zobrazeno 1 - 10
of 273
pro vyhledávání: '"CHK1 Inhibitor MK-8776"'
Autor:
Franza, Maria, Albanesi, Jacopo, Mancini, Benedetta, Pennisi, Rosa, Leone, Stefano, Acconcia, Filippo, Bianchi, Fabrizio, di Masi, Alessandra
Publikováno v:
In Biochemical Pharmacology August 2023 214
Autor:
Chung, Seung Woo, Kim, Gui Chul, Kweon, Seho, Lee, Hanul, Choi, Jeong Uk, Mahmud, Foyez, Chang, Hyo Won, Kim, Ji Won, Son, Woo-Chan, Kim, Sang Yoon, Byun, Youngro
Publikováno v:
In Biomaterials November 2018 182:35-43
Autor:
Webster, Jonathan A., Tibes, Raoul, Morris, Larry, Blackford, Amanda L., Litzow, Mark, Patnaik, Mrinal, Rosner, Gary L., Gojo, Ivana, Kinders, Robert, Wang, Lihua, Doyle, L. Austin, Huntoon, Catherine J., Karnitz, Larry M., Kaufmann, Scott H., Karp, Judith E., Smith, B. Douglas
Publikováno v:
In Leukemia Research October 2017 61:108-116
Interactions between the novel Chk1 inhibitor MK-8776 and the histone deacetylase (HDAC) inhibitor (HDACI) vorinostat were examined in human leukemia cells harboring wild-type (wt) or deficient p53. MK-8776 synergistically potentiated vorinostat-medi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fab23ba0a47c180e67c5dbeb32b18ae6
https://doi.org/10.1158/1535-7163.c.6536217
https://doi.org/10.1158/1535-7163.c.6536217
PDF file - 1275K, Supplemental Table 1. Synergism between MK-8776 and SBHA or vorinostat in various human leukemia cell lines. Supplemental Figure S1. SBHA or vorinostat significantly potentiates lethality of MK-8776 in leukemia cell lines. Supplemen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61aab150501944d5bbeb91bc867b331f
https://doi.org/10.1158/1535-7163.22499682.v1
https://doi.org/10.1158/1535-7163.22499682.v1
Akademický článek
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Autor:
Woo-Chan Son, Seung Woo Chung, Hyo Won Chang, Youngro Byun, Gui Chul Kim, Foyez Mahmud, Seho Kweon, Jeong Uk Choi, Ji Won Kim, Hanul Lee, Sang Yoon Kim
Publikováno v:
Biomaterials. 182:35-43
Metronomic chemotherapy, which is defined as a low-dose and frequent administration of cytotoxic drugs without drug-free breaks, has been recently emerged as an alternative to traditional MTD therapy and has shown therapeutic benefit in breast cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0a84205d1bd9d79b8965e7ff0747e01
https://doi.org/10.1016/j.biomaterials.2018.08.007
https://doi.org/10.1016/j.biomaterials.2018.08.007
Autor:
Jing-Quan Wang, Zhe-Sheng Chen, Dong-Hua Yang, Pranav Gupta, Ning Ji, Chao-Yun Cai, Xing-Duo Dong, Shuang Zhang, Yuqi Yang, Qingbin Cui
Publikováno v:
International Journal of Molecular Sciences
Volume 20
Issue 17
International Journal of Molecular Sciences, Vol 20, Iss 17, p 4095 (2019)
Volume 20
Issue 17
International Journal of Molecular Sciences, Vol 20, Iss 17, p 4095 (2019)
P-glycoprotein (P-gp), which is encoded by the ATP-binding cassette (ABC) transporter subfamily B member 1 (ABCB1) gene, is one of the most pivotal ABC transporters that transport its substrates across the cell membrane. Its overexpression is one of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb75dbc69a0b17a1d9946bf040628cdb
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
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Publikováno v:
Oncotarget
DNA damage activates Checkpoint kinase 1 (Chk1) to halt cell cycle progression thereby preventing further DNA replication and mitosis until the damage has been repaired. Consequently, Chk1 inhibitors have emerged as promising anticancer therapeutics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6df456bb5c98b2f556aabb5037af204
https://doi.org/10.18632/oncotarget.6364
https://doi.org/10.18632/oncotarget.6364