Zobrazeno 1 - 10
of 17
pro vyhledávání: '"CHK1, checkpoint kinase 1"'
Autor:
Hao Wang, Lei Wang, Keyi Jia, Yu Liu, Sha Zhao, Wei Li, Caicun Zhou, Minlin Jiang, Bin Chen, Yayi He
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 2983-2994 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 2983-2994 (2021)
Genomic instability remains an enabling feature of cancer and promotes malignant transformation. Alterations of DNA damage response (DDR) pathways allow genomic instability, generate neoantigens, upregulate the expression of programmed death ligand 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbe73202674a833d134ec811bcbf7332
https://doi.org/10.1016/j.apsb.2021.01.003
https://doi.org/10.1016/j.apsb.2021.01.003
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 2, Pp 309-321 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Cullin-RING ligases (CRLs) recognize and interact with substrates for ubiquitination and degradation, and can be targeted for disease treatment when the abnormal expression of substrates involves pathologic processes. Phosphorylation, either of subst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f27b7f488f3a53677836e1b8e5b2722d
https://doi.org/10.1016/j.apsb.2020.09.007
https://doi.org/10.1016/j.apsb.2020.09.007
Autor:
Andrew Dickson, Benjamin R. Stromberg, Christine Insinna, Matthew K. Summers, Yosup Rhee, Adrian E. Torres, Debjani Pal, Christopher J. Westlake, Mayank Singh, Amy C. Burrows
Publikováno v:
The Journal of Biological Chemistry
The deubiquitinating enzyme USP37 is known to contribute to timely onset of S phase and progression of mitosis. However, it is not clear if USP37 is required beyond S-phase entry despite expression and activity of USP37 peaking within S phase. We hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eedf7a343128548aa738f8cb79c88d9
http://europepmc.org/articles/PMC8487067
http://europepmc.org/articles/PMC8487067
Autor:
Qiao Liu, Beihua Kong, Xiaohe Hao, Jing Wang, Zhaojian Liu, Tingting Wu, Limei Xu, Xiyu Zhang, Changshun Shao, Junchao Qin, Yaoqin Gong, Shihua Lu
Publikováno v:
Redox Biology
Redox Biology, Vol 36, Iss, Pp 101604-(2020)
Redox Biology, Vol 36, Iss, Pp 101604-(2020)
Ovarian cancer is the most lethal gynecological malignancy. Abnormal homologous recombination repair, high level of reactive oxygen species (ROS) and upregulation of antioxidant genes are characteristic features of ovarian cancer. However, the molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fad2bdbadf81d66195e771f4ebe8cc4f
https://pubmed.ncbi.nlm.nih.gov/32554304
https://pubmed.ncbi.nlm.nih.gov/32554304
Autor:
Damayanthi Durairajanayagam
Publikováno v:
Arab Journal of Urology, Vol 16, Iss 1, Pp 10-20 (2018)
Arab Journal of Urology
Arab Journal of Urology
Objective: To examine the potential effects of lifestyle factors on male reproductive health. Evidence of a global decline in human sperm quality over recent decades has been accumulating. Environmental, occupational, and modifiable lifestyle factors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::487461ca5ff584320c93ca7ee26bcca4
https://doi.org/10.1016/j.aju.2017.12.004
https://doi.org/10.1016/j.aju.2017.12.004
Autor:
Petr Sova, PrashantKumar Khirsariya, Jarmila Herůdková, Kamil Paruch, Alois Kozubík, Olga Vondálová Blanářová, Alena Hyršlová Vaculová, Karel Souček, Martin Krkoška
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 19, Iss 10, Pp 830-841 (2017)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
Although Chk1 kinase inhibitors are currently under clinical investigation as effective cancer cell sensitizers to the cytotoxic effects of numerous chemotherapeutics, there is still a considerable uncertainty regarding their role in modulation of an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8e55b88e6b3d0b4832521ac44105099
http://www.sciencedirect.com/science/article/pii/S1476558617302452
http://www.sciencedirect.com/science/article/pii/S1476558617302452
Publikováno v:
Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 21, Iss 12, Pp 1143-1150 (2019)
Neoplasia: An International Journal for Oncology Research, Vol 21, Iss 12, Pp 1143-1150 (2019)
Chemoresistance is one of the leading causes of cancer-related deaths in the United States. Triple negative breast cancer (TNBC), a subtype lacking the known breast cancer receptors used for targeted therapy, is reliant on chemotherapy as the standar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::369502e33e9032d8e43fcc56f9429f59
https://pubmed.ncbi.nlm.nih.gov/31759252
https://pubmed.ncbi.nlm.nih.gov/31759252
Autor:
Philip M. Kubara, Aurélie Studeny, Sophie Kernéis-Golsteyn, Laurent Meijer, Roy M. Golsteyn, Brittany B. Lanser
Publikováno v:
Biochemical Journal
In the present paper, we report that mitosis is a key step in the cellular response to genotoxic agents in human cells. Cells with damaged DNA recruit γH2AX (phosphorylated histone H2AX), phosphorylate Chk1 (checkpoint kinase 1) and arrest in the G2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1ce6f65b68f0615eee04df2d1069ff2
https://doi.org/10.1042/bj20120385
https://doi.org/10.1042/bj20120385
Autor:
Jiang M; Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai 200433, China.; Medical School, Tongji University, Shanghai 200433, China., Jia K; Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai 200433, China.; Medical School, Tongji University, Shanghai 200433, China., Wang L; Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai 200433, China., Li W; Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai 200433, China., Chen B; Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai 200433, China., Liu Y; Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai 200433, China.; Medical School, Tongji University, Shanghai 200433, China., Wang H; Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai 200433, China.; Medical School, Tongji University, Shanghai 200433, China., Zhao S; Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai 200433, China., He Y; Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai 200433, China., Zhou C; Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai 200433, China.
Publikováno v:
Acta pharmaceutica Sinica. B [Acta Pharm Sin B] 2021 Oct; Vol. 11 (10), pp. 2983-2994. Date of Electronic Publication: 2021 Jan 06.
Autor:
Chen Y; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China., Shao X; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China., Cao J; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China., Zhu H; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China., Yang B; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China., He Q; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China., Ying M; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Publikováno v:
Acta pharmaceutica Sinica. B [Acta Pharm Sin B] 2021 Feb; Vol. 11 (2), pp. 309-321. Date of Electronic Publication: 2020 Sep 19.