Emerging roles of dysregulated adenosine homeostasis in brain disorders with a specific focus on neurodegenerative diseases

Autor: Ching-Pang Chang, Kuo-Chen Wu, Chien-Yu Lin, Yijuang Chern

Publikováno v: Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-25 (2021)

Abstract In modern societies, with an increase in the older population, age-related neurodegenerative diseases have progressively become greater socioeconomic burdens. To date, despite the tremendous effort devoted to understanding neurodegenerative

Externí odkaz: https://doaj.org/article/7a4488a5dd2743c1a2546ca3cdf7573b

Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington’s disease

Autor: Jian Jing Siew, Hui-Mei Chen, Huan-Yuan Chen, Hung-Lin Chen, Chiung-Mei Chen, Bing-Wen Soong, Yih-Ru Wu, Ching-Pang Chang, Yi-Chen Chan, Chun-Hung Lin, Fu-Tong Liu, Yijuang Chern

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)

The authors show that Galectin-3 is up–regulated in brain tissues from patients and a mouse model of Huntington’s disease (HD) and correlates with disease severity. Galectin-3 accumulates at damaged lysosomes in HD microglia, prevents the clearan

Externí odkaz: https://doaj.org/article/a6e1aa100a154ae9b970e162e6e98c2c

Longitudinal evaluation of an N-ethyl-N-nitrosourea-created murine model with normal pressure hydrocephalus.

Autor: Ming-Jen Lee, Ching-Pang Chang, Yi-Hsin Lee, Yi-Chih Wu, Hsu-Wen Tseng, Yu-Ying Tung, Min-Tzu Wu, Yen-Hui Chen, Lu-Ting Kuo, Dennis Stephenson, Shuen-Iu Hung, Jer-Yuarn Wu, Chen Chang, Yuan-Tsong Chen, Yijuang Chern

Publikováno v: PLoS ONE, Vol 4, Iss 11, p e7868 (2009)

BACKGROUND:Normal-pressure hydrocephalus (NPH) is a neurodegenerative disorder that usually occurs late in adult life. Clinically, the cardinal features include gait disturbances, urinary incontinence, and cognitive decline. METHODOLOGY/PRINCIPAL FIN

Externí odkaz: https://doaj.org/article/0ffa8da6c72d4d118d450ac150f08ff3

The nongenomic effects of progesterone, testosterone, estradiol, and glucocorticoid on human peripheral T cells

Autor: Ching-Pang Chang, 張敬邦

92
Steroids have been known to be involved in various physiological responses with a primary focus on the genomic aspects of action. Recently, increasing evidence for rapid, nongenomic steroid effects has been demonstrated for virtually all grou

Externí odkaz: http://ndltd.ncl.edu.tw/handle/68830144805507244787

Equilibrative nucleoside transporter 1 inhibition rescues energy dysfunction and pathology in a model of tauopathy

Autor: Ya Gin Chang, Luc Buée, Kuo Chen Wu, Ching Pang Chang, Fang Yi Chou, Vincent Huin, Lee-Way Jin, Sin-Jhong Cheng, David Blum, Yung-Feng Liao, Pei Yun Chuang, Thi Ngoc Anh Nguyen, Hui Mei Chen, Chun-Jung Lin, Yijuang Chern, Kevin Carvalho

Publikováno v: Acta Neuropathologica Communications
Acta Neuropathologica Communications, 2021, 9 (1), pp.112. ⟨10.1186/s40478-021-01213-7⟩
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-18 (2021)
Acta Neuropathologica Communications, BioMed Central part of Springer Science, 2021, 9 (1), pp.112. ⟨10.1186/s40478-021-01213-7⟩
Acta neuropathologica communications, vol 9, iss 1

Tau pathology is instrumental in the gradual loss of neuronal functions and cognitive decline in tauopathies, including Alzheimer’s disease (AD). Earlier reports showed that adenosine metabolism is abnormal in the brain of AD patients while consequ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6f0ba8cb343743295eb8124c0c2fa3c
https://www.hal.inserm.fr/inserm-03366697/file/s40478-021-01213-7.pdf