Zobrazeno 1 - 10
of 1 162
pro vyhledávání: '"CHIM/08 Chimica farmaceutica"'
Autor:
de Carvalho Bertozo L., Tutone M., Pastrello B., da Silva-Filho L. C., Culletta G., Almerico A. M., Farias Ximenes V.
An aminoquinoline (AQ4) was developed and proven to be a new and efficient DNA minor groove fluorescent probe. The specificity for DNA minor groove was attested by comparing it with well-established DNA probes such as Hoechst stain, acridine orange,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3658::a1535c436cd3445cffc1f4e7cce7bf7c
https://hdl.handle.net/10447/597973
https://hdl.handle.net/10447/597973
Autor:
Longbin Liu, Peter D. Johnson, Michael E. Prime, Vinod Khetarpal, Christopher J. Brown, Luca Anzillotti, Daniele Bertoglio, Xuemei Chen, Samuel Coe, Randall Davis, Anthony P. Dickie, Simone Esposito, Elise Gadouleau, Paul R. Giles, Catherine Greenaway, James Haber, Christer Halldin, Scott Haller, Sarah Hayes, Todd Herbst, Frank Herrmann, Manuela Heßmann, Ming Min Hsai, Yaser Khani, Adrian Kotey, Angelo Lembo, John E. Mangette, Gwendolyn A. Marriner, Richard W. Marston, Matthew R. Mills, Edith Monteagudo, Anton Forsberg-Morén, Sangram Nag, Laura Orsatti, Christine Sandiego, Sabine Schaertl, Joanne Sproston, Steven Staelens, Jack Tookey, Penelope A. Turner, Andrea Vecchi, Maria Veneziano, Ignacio Muñoz-Sanjuan, Jonathan Bard, Celia Dominguez
Publikováno v:
Journal of Medicinal Chemistry. 66:641-656
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74e78d658107fd1300b7add11eee0911
https://doi.org/10.1021/acs.jmedchem.2c01585
https://doi.org/10.1021/acs.jmedchem.2c01585
Autor:
Nigro, Michela
Chemotherapeutic drugs can in many ways disrupt the replication machinery triggering apoptosis in cancer cells: some act directly on DNA and others block the enzymes involved in preparing DNA for replication. Cisplatin-based drugs are common as first
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d21720d1cda45eae1fe425c55661b88a
http://amsdottorato.unibo.it/10869/
http://amsdottorato.unibo.it/10869/
Autor:
Rinaldi, Francesco <1993>
Different kinds of lesions can occur to DNA, and among them, one of the most dangerous is the double strand breaks (DSBs). Actually, DSBs can result in mutations, chromosome translocation or deletion. For this kind of lesions, depending on cell cycle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1754::d25a8b99c021c59a6c69eacee2755eb5
http://amsdottorato.unibo.it/10778/
http://amsdottorato.unibo.it/10778/
Autor:
Demuro, Stefania <1994>
Neuronal microtubules assembly and dynamics are regulated by several proteins including (MT)-associated protein tau, whose aberrant hyperphosphorylation promotes its dissociation from MTs and its abnormal deposition into neurofibrillary tangles, a co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1754::a72335d9cfeb4de65b73f4a5c61c25e0
http://amsdottorato.unibo.it/10775/
http://amsdottorato.unibo.it/10775/
Autor:
Pietro Salvatore Carollo, Marco Tutone, Giulia Culletta, Ignazio Fiduccia, Federica Corrao, Ivana Pibiri, Maria Grazia Zizzo, Raffaella Melfi, Andrea Pace, Anna Maria Almerico, Laura Lentini
Cystic Fibrosis (CF) is an autosomal recessive genetic disease caused by mutations in the CFTR gene, coding for the CFTR chloride channel. About 10% of the CFTR gene mutations are "stop" mutations, which generate a Premature Termination Codon (PTC),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3658::eb735107b3e0709e99f592758810dbef
https://hdl.handle.net/10447/592653
https://hdl.handle.net/10447/592653
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Universidad de Barcelona
The interest in the photochromism and functional applications of donor-acceptor Stenhouse adducts (DASAs) soared in recent years owing to their outstanding advantages and flexible design. However, their low solubility and irreversible conversion in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ddfd7b95f2d063e228fc8b8b971c28e
https://doi.org/10.1021/jacs.2c04920
https://doi.org/10.1021/jacs.2c04920
Novel tricyclic pyrrolo-quinolines as pharmacological correctors of the mutant CFTR chloride channel
Autor:
Renda M., Barreca M., Borrelli A., Spano' V., Montalbano A., Raimondi M. V., Bivacqua R., Musante I., Scudieri P., Guidone D., Buccirossi M., Genovese M., Venturini A., Bandiera T., Barraja P., Galietta L. J. V.
Publikováno v:
Scientific Reports. 13
F508del, the most frequent mutation in cystic fibrosis (CF), impairs the stability and folding of the CFTR chloride channel, thus resulting in intracellular retention and CFTR degradation. The F508del defect can be targeted with pharmacological corre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ad187e567b0fe97b88d1862050808e
https://doi.org/10.1038/s41598-023-34440-0
https://doi.org/10.1038/s41598-023-34440-0