Interaction of chikungunya virus glycoproteins with macrophage factors controls virion production.

Autor: Yao Z; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA., Ramachandran S; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA., Huang S; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Kim E; Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA., Jami-Alahmadi Y; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, USA., Kaushal P; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA.; Institute for Quantitative and Computational Biosciences, University of California, Los Angeles, Los Angeles, CA, USA.; Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA, USA., Bouhaddou M; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA.; Institute for Quantitative and Computational Biosciences, University of California, Los Angeles, Los Angeles, CA, USA.; Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA, USA., Wohlschlegel JA; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, USA., Li MM; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA. Manhingli@mednet.ucla.edu.; Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA, USA. Manhingli@mednet.ucla.edu.

Publikováno v: The EMBO journal [EMBO J] 2024 Oct; Vol. 43 (20), pp. 4625-4655. Date of Electronic Publication: 2024 Sep 11.

Detection of dengue virus and chikungunya virus in wastewater in Portugal: an exploratory surveillance study.

Autor: Monteiro S; Laboratório de Análises, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal; Civil Engineering Research and Innovation for Sustainability, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal; Department of Nuclear Sciences and Engineering, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal. Electronic address: silvia.monteiro@tecnico.ulisboa.pt., Pimenta R; Laboratório de Análises, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal., Nunes F; Laboratório de Análises, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal., Cunha MV; Centre for Ecology, Evolution and Environmental Changes and CHANGE Institute for Global Change and Sustainability, Faculdade de Ciências, Universidade de Lisboa, Lisbon, Portugal; Biosystems and Integrative Sciences Institute, Faculdade de Ciências, Universidade de Lisboa, Lisbon, Portugal., Santos R; Laboratório de Análises, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal; Civil Engineering Research and Innovation for Sustainability, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal; Department of Nuclear Sciences and Engineering, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal. Electronic address: ricardosantos@tecnico.ulisboa.pt.

Publikováno v: The Lancet. Microbe [Lancet Microbe] 2024 Nov; Vol. 5 (11), pp. 100911. Date of Electronic Publication: 2024 Sep 12.

Identification of a cell-active chikungunya virus nsP2 protease inhibitor using a covalent fragment-based screening approach.

Autor: Merten EM; Eshelman School of Pharmacy, Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599., Sears JD; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599., Leisner TM; Eshelman School of Pharmacy, Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599., Hardy PB; Eshelman School of Pharmacy, Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599., Ghoshal A; Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599., Hossain MA; Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599., Asressu KH; Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599., Brown PJ; Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599., Tse EG; Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599., Stashko MA; Eshelman School of Pharmacy, Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599., Li K; Eshelman School of Pharmacy, Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599., Norris-Drouin JL; Eshelman School of Pharmacy, Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599., Herring LE; Proteomics Core Facility, Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599., Mordant AL; Proteomics Core Facility, Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599., Webb TS; Proteomics Core Facility, Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599., Mills CA; Proteomics Core Facility, Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599., Barker NK; Proteomics Core Facility, Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599., Streblow ZJ; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR 97006., Perveen S; Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada., Arrowsmith CH; Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada., Couñago RM; Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.; Center of Medicinal Chemistry, Center for Molecular Biology and Genetic Engineering, University of Campinas, Campinas, SP 13083-886, Brazil., Arnold JJ; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599., Cameron CE; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599., Streblow DN; Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR 97006., Moorman NJ; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599., Heise MT; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599., Willson TM; Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599., Popov KI; Eshelman School of Pharmacy, Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599., Pearce KH; Eshelman School of Pharmacy, Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.; Lineberger Comprehensive Cancer Center, Molecular Therapeutics Research Program, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Oct 15; Vol. 121 (42), pp. e2409166121. Date of Electronic Publication: 2024 Oct 10.

Underdiagnosis of arbovirus infections in returned travelers in an area with growing circulation of Aedes albopictus in North-Eastern France.

Autor: Parfut A; Virology Laboratory, Strasbourg University Hospital, Strasbourg, France., Gantner P; Virology Laboratory, Strasbourg University Hospital, Strasbourg, France; INSERM, IRM UMR-S 1109, Strasbourg University, Strasbourg France., Hoellinger B; Tropical Medicine and Infectious Diseases Department, Strasbourg University Hospital, Strasbourg, France., Ferreira L; Pediatric Department, Strasbourg University Hospital, Strasbourg, France., Biry M; Medical Parasitology and Mycology Laboratory, Strasbourg University Hospitals, Strasbourg, France., Hansmann Y; Tropical Medicine and Infectious Diseases Department, Strasbourg University Hospital, Strasbourg, France., Filisetti D; Medical Parasitology and Mycology Laboratory, Strasbourg University Hospitals, Strasbourg, France., Fafi-Kremer S; Virology Laboratory, Strasbourg University Hospital, Strasbourg, France; INSERM, IRM UMR-S 1109, Strasbourg University, Strasbourg France., Brunet J; Medical Parasitology and Mycology Laboratory, Strasbourg University Hospitals, Strasbourg, France., Velay A; Virology Laboratory, Strasbourg University Hospital, Strasbourg, France; INSERM, IRM UMR-S 1109, Strasbourg University, Strasbourg France. Electronic address: aurelie.velay@chru-strasbourg.fr.

Publikováno v: Infectious diseases now [Infect Dis Now] 2024 Oct; Vol. 54 (7), pp. 104956. Date of Electronic Publication: 2024 Jul 21.

Understanding the factors contributing to dengue virus and chikungunya virus seropositivity and seroconversion among children in Kenya.

Autor: Tariq A; Department of Pediatrics, Division of Infectious Diseases, Stanford University, Palo Alto, California, United States of America., Khan A; Department of Pediatrics, Division of Infectious Diseases, Stanford University, Palo Alto, California, United States of America., Mutuku F; Department of Environment and Health Sciences, Technical University of Mombasa, Mombasa, Kenya., Ndenga B; Centre for Global Health Research, Kenya, Medical Research Institute, Kisumu, Kenya., Bisanzio D; RTI International, Washington, D.C, United States of America., Grossi-Soyster EN; Department of Pediatrics, Division of Infectious Diseases, Stanford University, Palo Alto, California, United States of America., Jembe Z; Vector borne Disease control Unit, Msambweni County Referral Hospital, Msambweni, Kenya., Maina P; Vector borne Disease control Unit, Msambweni County Referral Hospital, Msambweni, Kenya., Chebii P; Vector borne Disease control Unit, Msambweni County Referral Hospital, Msambweni, Kenya., Ronga C; Centre for Global Health Research, Kenya, Medical Research Institute, Kisumu, Kenya., Okuta V; Centre for Global Health Research, Kenya, Medical Research Institute, Kisumu, Kenya., LaBeaud AD; Department of Pediatrics, Division of Infectious Diseases, Stanford University, Palo Alto, California, United States of America.

Publikováno v: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2024 Nov 20; Vol. 18 (11), pp. e0012616. Date of Electronic Publication: 2024 Nov 20 (Print Publication: 2024).