Novel antibodies reveal presynaptic localization of C9orf72 protein and reduced protein levels in C9orf72 mutation carriers

Autor: Petra Frick, Chantal Sellier, Ian R. A. Mackenzie, Chieh-Yu Cheng, Julie Tahraoui-Bories, Cecile Martinat, R. Jeroen Pasterkamp, Johannes Prudlo, Dieter Edbauer, Mustapha Oulad-Abdelghani, Regina Feederle, Nicolas Charlet-Berguerand, Manuela Neumann

Publikováno v: Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-17 (2018)

Abstract Hexanucleotide repeat expansion in C9orf72 is the most common genetic cause of frontotemporal dementia and amyotrophic lateral sclerosis, but the pathogenic mechanism of this mutation remains unresolved. Haploinsufficiency has been proposed

Externí odkaz: https://doaj.org/article/e5e7a7e62889463ba2a09bee67f7bfd4

Characterization of influenza A (H7N9) viruses isolated from human cases imported into Taiwan.

Autor: Ji-Rong Yang, Chuan-Yi Kuo, Hsiang-Yi Huang, Fu-Ting Wu, Yi-Lung Huang, Chieh-Yu Cheng, Yu-Ting Su, Ho-Sheng Wu, Ming-Tsan Liu

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0119792 (2015)

A novel avian influenza A (H7N9) virus causes severe human infections and was first identified in March 2013 in China. The H7N9 virus has exhibited two epidemiological peaks of infection, occurring in week 15 of 2013 and week 5 of 2014. Taiwan, which

Externí odkaz: https://doaj.org/article/cc20f834cb17469e86be15feb0382c4a

A virus-like particle vaccination strategy expands its tolerance to H3N2 antigenic drift by enhancing neutralizing antibodies against hemagglutinin stalk

Autor: Yu-Chih Yang, Chia-Ying Wu, Chih-Yuan Chen, Fu-Ting Wu, Ji-Rong Yang, Chao-Hua Lin, Ming-Tsan Liu, Chieh-Yu Cheng, Hsiang-Yi Huang, Chuan-Yi Kuo, Pei-Wen Hsiao

Publikováno v: Antiviral Research. 140:62-75

Seasonal influenza viruses impact public health annually due to their continual evolution. However, the current inactivated seasonal vaccines provide poor protection against antigenically drifted viruses and require periodical reformulation through h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dba62a8affcb4ead650ad88cdb9508e7
https://doi.org/10.1016/j.antiviral.2017.01.010

A novel H6N1 virus-like particle vaccine induces long-lasting cross-clade antibody immunity against human and avian H6N1 viruses

Autor: Chieh-Yu Cheng, Chia-Ying Wu, Ming-Tsan Liu, Ho-Sheng Wu, Chuan-Yi Kuo, Min-Shiuh Lee, Pei-Wen Hsiao, Ming-Chu Cheng, Yu-Chih Yang, Chih-Yuan Chen, Ji-Rong Yang

Publikováno v: Antiviral Research. 126:8-17

Avian influenza A(H6N1) virus is one of the most common viruses isolated from migrating birds and domestic poultry in many countries. The first and only known case of human infection by H6N1 virus in the world was reported in Taiwan in 2013. This led

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fb57e0d24c4f8f6d260bb4ac4326fd4
https://doi.org/10.1016/j.antiviral.2015.10.019

Novel antibodies reveal presynaptic localization of C9orf72 protein and reduced protein levels in C9orf72 mutation carriers

Autor: R. Jeroen Pasterkamp, Manuela Neumann, Mustapha Oulad-Abdelghani, Chieh-Yu Cheng, Julie Tahraoui-Bories, Chantal Sellier, Regina Feederle, Petra Frick, Dieter Edbauer, Nicolas Charlet-Berguerand, Cécile Martinat, Ian R. A. Mackenzie, Johannes Prudlo

Publikováno v: Acta Neuropathologica Communications
Acta Neuropathologica Communications, BioMed Central part of Springer Science, 2018, 6 (1), ⟨10.1186/s40478-018-0579-0⟩
Acta Neuropathologica Communications, 2018, 6 (1), ⟨10.1186/s40478-018-0579-0⟩
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-17 (2018)
Acta Neuropathol. Commun. 6:72 (2018)
Acta Neuropathologica Communications 6(1), 72 (2018). doi:10.1186/s40478-018-0579-0

Hexanucleotide repeat expansion in C9orf72 is the most common genetic cause of frontotemporal dementia and amyotrophic lateral sclerosis, but the pathogenic mechanism of this mutation remains unresolved. Haploinsufficiency has been proposed as one po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14cc66032c715f6812ce4cede48be218
https://hal.archives-ouvertes.fr/hal-03339513