Zobrazeno 1 - 10
of 145
pro vyhledávání: '"CHI-LIN TSAI"'
Autor:
Jina Yu, Chunli Yan, Tanmoy Paul, Lucas Brewer, Susan E. Tsutakawa, Chi-Lin Tsai, Samir M. Hamdan, John A. Tainer, Ivaylo Ivanov
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Nucleotide excision repair (NER) is vital for genome integrity. Yet, our understanding of the complex NER protein machinery remains incomplete. Combining cryo-EM and XL-MS data with AlphaFold2 predictions, we build an integrative model of th
Externí odkaz:
https://doaj.org/article/a276deed1bfe43f4a4971adb82242900
Autor:
Jie Fu, Jianhua Ling, Ching-Fei Li, Chi-Lin Tsai, Wenjuan Yin, Junwei Hou, Ping Chen, Yu Cao, Ya’an Kang, Yichen Sun, Xianghou Xia, Zhou Jiang, Kenei Furukawa, Yu Lu, Min Wu, Qian Huang, Jun Yao, David H. Hawke, Bih-Fang Pan, Jun Zhao, Jiaxing Huang, Huamin Wang, E. I. Mustapha Bahassi, Peter J. Stambrook, Peng Huang, Jason B. Fleming, Anirban Maitra, John A. Tainer, Mien-Chie Hung, Chunru Lin, Paul J. Chiao
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Pancreatic ductal adenocarcinoma (PDAC) develops through step-wise genetic and molecular alterations including Kras mutation and inactivation of various apoptotic pathways. Here, we find that development of apoptotic resistance and metastasi
Externí odkaz:
https://doaj.org/article/c655bcead33042daab28080db2e56eaa
Autor:
Jina Yu, Chunli Yan, Thomas Dodd, Chi-Lin Tsai, John A. Tainer, Susan E. Tsutakawa, Ivaylo Ivanov
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Transcription factor IIH (TFIIH) is a protein assembly essential for transcription initiation and nucleotide excision repair (NER). Yet, understanding of the conformational switching underpinning these diverse TFIIH functions remains fragmen
Externí odkaz:
https://doaj.org/article/ae5a3d72e0f443e8bd13f58a35d7e016
Autor:
Hou-Fu Guo, Neus Bota-Rabassedas, Masahiko Terajima, B. Leticia Rodriguez, Don L. Gibbons, Yulong Chen, Priyam Banerjee, Chi-Lin Tsai, Xiaochao Tan, Xin Liu, Jiang Yu, Michal Tokmina-Roszyk, Roma Stawikowska, Gregg B. Fields, Mitchell D. Miller, Xiaoyan Wang, Juhoon Lee, Kevin N. Dalby, Chad J. Creighton, George N. Phillips, John A. Tainer, Mitsuo Yamauchi, Jonathan M. Kurie
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
Guo et al. determine the molecular basis of collagen lysyl hydroxylase 2 (LH2) substrate specificity. They further show that LH2 also functions as a collagen glucosyltransferase to promote lung cancer progression.
Externí odkaz:
https://doaj.org/article/33c609a5058f4848b50950a0e6133563
Publikováno v:
Breast, Vol 52, Iss , Pp 116-121 (2020)
Background: Obesity has long been considered a risk factor for breast cancer–related lymphedema (BCRL), but the benefits of weight reduction in managing BCRL have not been clearly established. Objective: To evaluate the beneficial effects of weight
Externí odkaz:
https://doaj.org/article/4633527451444029b595e4af863e19eb
Autor:
Susan E. Tsutakawa, Albino Bacolla, Panagiotis Katsonis, Amer Bralić, Samir M. Hamdan, Olivier Lichtarge, John A. Tainer, Chi-Lin Tsai
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
All tumors have DNA mutations, and a predictive understanding of those mutations could inform clinical treatments. However, 40% of the mutations are variants of unknown significance (VUS), with the challenge being to objectively predict whether a VUS
Externí odkaz:
https://doaj.org/article/ad91801f67d54b42bcc420e45cea724e
Publikováno v:
Asian Journal for Public Opinion Research, Vol 7, Iss 1, Pp 57-74 (2019)
Researchers usually examine the quality of survey data by several conventional measures of reliability and validity. However, those measures are mainly designed to examine the quality of an individual measurement, rather than the quality of a data se
Externí odkaz:
https://doaj.org/article/dbca1c0d23e94cca9cec03554a917b06
Autor:
Hou-Fu Guo, Chi-Lin Tsai, Masahiko Terajima, Xiaochao Tan, Priyam Banerjee, Mitchell D. Miller, Xin Liu, Jiang Yu, Jovita Byemerwa, Sarah Alvarado, Tamer S. Kaoud, Kevin N. Dalby, Neus Bota-Rabassedas, Yulong Chen, Mitsuo Yamauchi, John A. Tainer, George N. Phillips, Jonathan M. Kurie
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Collagen lysyl hydroxylases promote cancer progression. Here the authors present the crystal structure of the lysyl hydroxylase domain of L230 from Acanthamoeba polyphaga mimivirus, which is of interest for LH inhibitor development, and show that ect
Externí odkaz:
https://doaj.org/article/66b3577e6b604e7983c92825500bf879
Autor:
Mihyun Kim, Hyun-Suk Kim, Areetha D’Souza, Kaitlyn Gallagher, Eunwoo Jeong, Agnieszka Topolska-Woś, Kateryna Ogorodnik Le Meur, Chi-Lin Tsai, Miaw-Sheue Tsai, Minyong Kee, John A. Tainer, Jung-Eun Yeo, Walter J. Chazin, Orlando D. Schärer
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(34)
The xeroderma pigmentosum protein A (XPA) and replication protein A (RPA) proteins fulfill essential roles in the assembly of the preincision complex in the nucleotide excision repair (NER) pathway. We have previously characterized the two interactio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e7f5d1d0b7113d6588abb317faebf8a
https://pubmed.ncbi.nlm.nih.gov/35969784
https://pubmed.ncbi.nlm.nih.gov/35969784
A scanning-to-incision switch in TFIIH-XPG induced by DNA damage licenses nucleotide excision repair
Autor:
Amer Bralić, Muhammad Tehseen, Mohamed A Sobhy, Chi-Lin Tsai, Lubna Alhudhali, Gang Yi, Jina Yu, Chunli Yan, Ivaylo Ivanov, Susan E Tsutakawa, John A Tainer, Samir M Hamdan
Publikováno v:
Nucleic acids research, vol 51, iss 3
Nucleotide excision repair (NER) is critical for removing bulky DNA base lesions and avoiding diseases. NER couples lesion recognition by XPC to strand separation by XPB and XPD ATPases, followed by lesion excision by XPF and XPG nucleases. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::728d99a4e91f52634426964accffcb30
https://pubmed.ncbi.nlm.nih.gov/36477609
https://pubmed.ncbi.nlm.nih.gov/36477609