Zobrazeno 1 - 10
of 23
pro vyhledávání: '"CHATCHAI PHOOMAK"'
Autor:
Thomas J. Hayman, Marta Baro, Tyler MacNeil, Chatchai Phoomak, Thazin Nwe Aung, Wei Cui, Kevin Leach, Radhakrishnan Iyer, Sreerupa Challa, Teresa Sandoval-Schaefer, Barbara A. Burtness, David L. Rimm, Joseph N. Contessa
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
The endoplasmic reticulum-localized adaptor STING regulates the innate immune response through its ability to sense DNA damage. Here the authors reveal that STING functions as a regulator of cellular ROS homeostasis and tumor cell susceptibility to r
Externí odkaz:
https://doaj.org/article/7f9f99967a354a5b93d3fe5db608fc2d
Autor:
Chatchai Phoomak, Dayoung Park, Atit Silsirivanit, Kanlayanee Sawanyawisuth, Kulthida Vaeteewoottacharn, Marutpong Detarya, Chaisiri Wongkham, Carlito B. Lebrilla, Sopit Wongkham
Publikováno v:
Molecular Oncology, Vol 13, Iss 2, Pp 338-357 (2019)
O‐GlcNAcylation is a key post‐translational modification that modifies the functions of proteins. Associations between O‐GlcNAcylation, shorter survival of cholangiocarcinoma (CCA) patients, and increased migration/invasion of CCA cell lines ha
Externí odkaz:
https://doaj.org/article/482137518b9d4e0287a97bc77c319340
Autor:
SURANG CHOMPHOO, WARITTA KUNPROM, KANYARAT THITHUAN, SUPANNIKA SORIN, KULLANAT KHAWKHIAW, ANYANEE KAMKAEW, CHATCHAI PHOOMAK, CHING-FENG CHIU, CHARUPONG SAENGBOONMEE
Publikováno v:
In Vivo
Background/Aim: Diabetes mellitus (DM) is an established risk for hepatocellular carcinoma (HCC), with unclarified mechanisms. This study investigated the effects of hyperglycemia on O-GlcNacylation in hepatocytes and its associations with hepatocarc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62e3a78971b8a1c06cb5daf4fbd193f7
https://doi.org/10.21873/invivo.13129
https://doi.org/10.21873/invivo.13129
Autor:
Chatchai Phoomak, Natalie Rinis, Marta Baro, Shiteshu Shrimal, Daniel Bennett, Scott A. Shaffer, Mark Lehrman, Reid Gilmore, Joseph N. Contessa
Publikováno v:
Science Advances. 9
Proteins destined for the secretory compartment of the cell are cotranslationally translocated into the endoplasmic reticulum. The majority of these proteins are N-glycosylated, a co- and posttranslational modification that ensures proper protein fol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d4f011d8e03c7842a38ab5a3a073719
https://doi.org/10.1126/sciadv.ade8079
https://doi.org/10.1126/sciadv.ade8079
Autor:
Wei Cui, David L. Rimm, Kevin Leach, Thazin Nwe Aung, Radhakrishnan P. Iyer, Sreerupa Challa, Barbara Burtness, Thomas J. Hayman, Chatchai Phoomak, Tyler MacNeil, Joseph N. Contessa, Marta Baro, Teresa Sandoval-Schaefer
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Resistance to DNA-damaging agents is a significant cause of treatment failure and poor outcomes in oncology. To identify unrecognized regulators of cell survival we performed a whole-genome CRISPR-Cas9 screen using treatment with ionizing radiation a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::742835bcd26216b89b828bb921aa7025
https://doi.org/10.1038/s41467-021-22572-8
https://doi.org/10.1038/s41467-021-22572-8
Autor:
Chatchai Phoomak, Joseph N. Contessa
Publikováno v:
Cancer Research. 82:3981-3981
PURPOSE: Lung cancer is a major cause of morbidity and mortality world wide. Signaling receptors, adhesion molecules, and surface antigens that drive lung cancer progression are regulated by N-glycosylation, a post-translational protein modification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f95b9921622b02b638899fea8cd6bf11
https://doi.org/10.1158/1538-7445.am2022-3981
https://doi.org/10.1158/1538-7445.am2022-3981
Publikováno v:
Cancer Research. 82:3315-3315
Purpose: Although Head and Neck Squamous Cell Carcinoma (HNSCC) is the sixth most common cancer worldwide, the high failure rates for non-HPV associated tumors and the absence of new effective therapies has caused the survival rate for HNSCC to remai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8945ae50a7f7209446a3cd70b3bb0d05
https://doi.org/10.1158/1538-7445.am2022-3315
https://doi.org/10.1158/1538-7445.am2022-3315
Publikováno v:
Diagnosis and Management of Cholangiocarcinoma ISBN: 9783030709358
With advancing technology in glycobiology research over the past decade, there is now a large and ever-growing number of publications examining the biological and clinical significance of glycosylation in human diseases. In cholangiocarcinoma (CCA),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85c6756c0cf38a662386cc898038fa4f
https://doi.org/10.1007/978-3-030-70936-5_25
https://doi.org/10.1007/978-3-030-70936-5_25
Autor:
Richard Steet, Lance Wells, Seok-Ho Yu, Wei Cui, Peng Zhao, Thomas J. Hayman, Chatchai Phoomak, Joseph N. Contessa
Publikováno v:
Science Advances
A new method for detecting N-glycosylation reveals a role for the TRAP complex and a mechanism for cell state–specific regulation.
Asparagine (N)–linked glycosylation is required for endoplasmic reticulum (ER) homeostasis, but how this co- a
Asparagine (N)–linked glycosylation is required for endoplasmic reticulum (ER) homeostasis, but how this co- a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59064b13ea45b20a528e52942a8ee77b
http://europepmc.org/articles/PMC7810369
http://europepmc.org/articles/PMC7810369
Autor:
Worachart Lert-itthiporn, Michiko Shimoda, Simon S. Park, Sopit Wongkham, Guillaume Luxardi, Khiem Tran, Qiongyu Li, Nobuyuki Matoba, Emanual Michael Maverakis, Laura P. Olney, Fernando A. Fierro, Nathan E. Haigh, Chatchai Phoomak, Carlito B. Lebrilla, Dayoung Park, Gege Xu
Publikováno v:
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 14
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 14
Membrane-bound oligosaccharides form the interfacial boundary between the cell and its environment, mediating processes such as adhesion and signaling. These structures can undergo dynamic changes in composition and expression based on cell type, ext
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97a4ced7c5f587d1c55882ce0d6f1a8a
https://pubmed.ncbi.nlm.nih.gov/32213588
https://pubmed.ncbi.nlm.nih.gov/32213588