Zobrazeno 1 - 2
of 2
pro vyhledávání: '"CHARITY A. DEAN"'
Publikováno v:
Southern Medical Journal. 93:881-884
Autor:
Sarah Cox, Michael D. Boisclair, Charity L. Dean, Philip M. Czerniak, Pieter F. W. Stouten, David A. Nugiel, Steven P. Seitz, Chong-Hwan Chang, Catherine R. Burton, Marc R. Arnone, Lisa M. Sisk, Robert F. Kaltenbach, Barbara A. Harrison, Pamela A. Benfield, Robert H. Grafstrom, Jay A. Markwalder, Susan R. Sherk, Karen A. Rossi, Deborah Doleniak, Peter Worland, George L. Trainor
Publikováno v:
Journal of medicinal chemistry. 47(24)
Using a high-throughput screening strategy, a series of 1-aryl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-ones was identified that inhibit the cyclin-dependent kinase (CDK) 4/cyclin D1 complex-mediated phosphorylation of a protein substrate with IC(50