Zobrazeno 1 - 10
of 18
pro vyhledávání: '"CHARGE Inflammation Working Group"'
Autor:
Adam X. Maihofer, Andrew Ratanatharathorn, Sian M. J. Hemmings, Karen H. Costenbader, Vasiliki Michopoulos, Renato Polimanti, Alex O. Rothbaum, Soraya Seedat, Elizabeth A. Mikita, CHARGE Inflammation Working Group, Psychiatric Genomics Consortium PTSD Working Group, Alicia K. Smith, Rany M. Salem, Richard A. Shaffer, Tianying Wu, Jonathan Sebat, Kerry J. Ressler, Murray B. Stein, Karestan C. Koenen, Erika J. Wolf, Jennifer A. Sumner, Caroline M. Nievergelt
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Observational studies suggest that posttraumatic stress disorder (PTSD) increases risk for various autoimmune diseases. Insights into shared biology and causal relationships between these diseases may inform intervention approaches to PTSD a
Externí odkaz:
https://doaj.org/article/3c74f81f134f46e6b77fd3adc226573a
Autor:
Melody Kasher, Maxim B. Freidin, Frances M. K. Williams, Gregory Livshits, CHARGE Inflammation Working Group
Publikováno v:
Biomolecules, Vol 14, Iss 5, p 563 (2024)
Inflammageing is a condition of perpetual low-grade inflammation induced by ageing. Inflammageing may be predicted by the C-reactive protein (CRP) or by a recently described biomarker which measures N-glycosylated side chains of the carbohydrate comp
Externí odkaz:
https://doaj.org/article/112ba8f722a74621936487af4ddb0c10
Autor:
Marijne Vandebergh, Sara Becelaere, CHARGE Inflammation Working Group, Bénédicte Dubois, An Goris
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
ObjectivesWe explored whether genetically predicted increased body mass index (BMI) modulates multiple sclerosis (MS) risk through interleukin-6 (IL-6) signaling.MethodsWe performed a two-sample Mendelian randomization (MR) study using multiple genom
Externí odkaz:
https://doaj.org/article/8d51cd09c2194f768defda4b10402b8a
Autor:
Symen Ligthart, Paul S de Vries, André G Uitterlinden, Albert Hofman, CHARGE Inflammation working group, Oscar H Franco, Daniel I Chasman, Abbas Dehghan
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0118859 (2015)
Pleiotropic genetic variants have independent effects on different phenotypes. C-reactive protein (CRP) is associated with several cardiometabolic phenotypes. Shared genetic backgrounds may partially underlie these associations. We conducted a genome
Externí odkaz:
https://doaj.org/article/336a5522e5704514bd4364fed18daa96
Autor:
Maners, Jillian *, Gill, Dipender *, Pankratz, Nathan, Laffan, Michael A., Wolberg, Alisa S., de Maat, Moniek P.M., Ligthart, Symen, Tang, Weihong, Ward-Caviness, Cavin K., Fornage, Myriam, Debette, Stephanie, Dichgans, Martin, McKnight, Barbara, Boerwinkle, Eric, CHARGE Inflammation Working Group, INVENT Consortium, MEGASTROKE consortium of the International Stroke Genetics Consortium (ISGC), Smith, Nicholas L., Morrison, Alanna C., Dehghan, Abbas, de Vries, Paul S. *
Publikováno v:
In Blood 24 December 2020 136(26):3062-3069
Akademický článek
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Autor:
Kasher, Melody, Williams, Frances MK, Freidin, Maxim B, Malkin, Ida, Cherny, Stacey S, CHARGE Inflammation Working Group, Livshits, Gregory
Publikováno v:
Human molecular genetics, vol 31, iss 16
Rheumatoid arthritis (RA) and osteoporosis (OP) are two comorbid complex inflammatory conditions with evidence of shared genetic background and causal relationships. We aimed to clarify the genetic architecture underlying RA and various OP phenotypes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::1342c9bb2ec25254e93b20d504c7aa1b
https://escholarship.org/uc/item/74j0871t
https://escholarship.org/uc/item/74j0871t
Autor:
Vandebergh, Marijne, Becelaere, Sara, CHARGE Inflammation Working Group, Dubois, Bénédicte, Goris, An
ObjectivesWe explored whether genetically predicted increased body mass index (BMI) modulates multiple sclerosis (MS) risk through interleukin-6 (IL-6) signaling.MethodsWe performed a two-sample Mendelian randomization (MR) study using multiple genom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8bd31ded799a99862ff35f455b53c45
https://lirias.kuleuven.be/handle/20.500.12942/692711
https://lirias.kuleuven.be/handle/20.500.12942/692711
Autor:
Ahluwalia, TS, Prins, BP, Abdollahi, M, Armstrong, NJ, Aslibekyan, S, Bain, L, Jefferis, B, Baumert, J, Beekman, M, Ben-Shlomo, Y, Bis, JC, Mitchell, BD, de Geus, E, Delgado, GE, Marek, D, Eriksson, J, Kajantie, E, Kanoni, S, Kemp, JP, Lu, C, Marioni, RE, McLachlan, S, Milaneschi, Y, Nolte, IM, Petrelis, AM, Porcu, E, Sabater-Lleal, M, Naderi, E, Seppälä, I, Shah, T, Singhal, G, Standl, M, Teumer, A, Thalamuthu, A, Thiering, E, Trompet, S, Ballantyne, CM, Benjamin, EJ, Casas, JP, Toben, C, Dedoussis, G, Deelen, J, Durda, P, Engmann, J, Feitosa, MF, Grallert, H, Hammarstedt, A, Harris, SE, Homuth, G, Hottenga, J-J, Jalkanen, S, Jamshidi, Y, Jawahar, MC, Jess, T, Kivimaki, M, Kleber, ME, Lahti, J, Liu, Y, Marques-Vidal, P, Mellström, D, Mooijaart, SP, Müller-Nurasyid, M, Penninx, B, Revez, JA, Rossing, P, Räikkönen, K, Sattar, N, Scharnagl, H, Sennblad, B, Silveira, A, Pourcain, BS, Timpson, NJ, Trollor, J, CHARGE Inflammation Working Group, van Dongen, J, Van Heemst, D, Visvikis-Siest, S, Vollenweider, P, Völker, U, Waldenberger, M, Willemsen, G, Zabaneh, D, Morris, RW, Arnett, DK, Baune, BT, Boomsma, DI, Chang, Y-PC, Deary, IJ, Deloukas, P, Eriksson, JG, Evans, DM, Ferreira, MA, Gaunt, T, Gudnason, V, Hamsten, A, Heinrich, J, Hingorani, A, Humphries, SE, Jukema, JW, Koeing, W, Kumari, M, Kutalik, Z, Lawlor, DA, Lehtimäki, T, März, W, Mather, K, Naitza, S, Nauck, M, Ohlsson, C, Price, JF, Raitakari, O, Rice, K, Sachdev, PS, Slagboom, E, Sørensen, TIA, Spector, T, Stacey, D, Stathopoulou, MG, Tanaka, T, Wannamethee, SG, Whincup, P, Rotter, JI, Dehghan, A, Boerwinkle, E, Psaty, BM, Snieder, H, Alizadeh, BZ
Interleukin-6 (IL-6) is a multifunctional cytokine with both pro- and anti-inflammatory properties with a heritability estimate of up to 61%. The circulating levels of IL-6 in blood have been associated with an increased risk of complex disease patho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::043796f2040210709135c769baeddf98
https://openaccess.sgul.ac.uk/id/eprint/112959/9/ddab023.pdf
https://openaccess.sgul.ac.uk/id/eprint/112959/9/ddab023.pdf
Autor:
Georgakis, Marios K, Malik, Rainer, Gordon, William, Davey-Smith, George, Morrison, Alanna C, Hicks, Andrew, van Duijn, Cornelia M, Ward-Caviness, Cavin, Boerwinkle, Eric, Rotter, J., Rice, Ken, Lange, Leslie, Perola, Markus, van Hylckama Vlieg, Astrid, de Geus, Eco, Morris, Andrew P, Makela, Kari Matti, Stacey, David, Eriksson, Johan, Frayling, Tim M, Slagboom, Eline P, de Andrade, Mariza, Brody, Jennifer A, Pattee, Jack W, Haessler, Jeffrey, Brumpton, Ben M, Chasman, Daniel I, Suchon, Pierre, Chen, Ming-Huei, Gill, Dipender, Turman, Constance, Germain, Marine, Wiggins, Kerri L, MacDonald, James, Braekkan, Sigrid K, Armasu, Sebastian M, Pankratz, Nathan, Jackson, Rabecca D, Nielsen, Jonas B, Giulianini, Franco, Franceschini, Nora, Puurunen, Marja K, Ibrahim, Manal, Heckbert, Susan R, Damrauer, Scott M, Natarajan, Pradeep, Klarin, Derek, de Vries, Paul S, SabaterLleal, Maria, Huffman, Jennifer E, Bammler, Theo K, Sudlow, Cathie L M, Frazer, Kelly A, McCauley, Bryan M, Taylor, Kent, Pankow, James S, Reiner, Alexander P, Gabrielsen, Maiken E, Deleuze, Jean-François, O'Donnell, Chris J, Kim, Jihye, McKnight, Barbara, Dichgans, Martin, Kraft, Peter, Hansen, JohnBjarne, Rosendaal, Frits R, Heit, John A, Psaty, Bruce M, Tang, Weihong, Kooperberg, Charles, Hveem, Kristian, Ridker, Paul M, Morange, Pierre Emmanuel, INVENT Consortium, CHARGE Inflammation Working Group, Johnson, Andrew D, Kabrhel, Christopher, Trégouët, David-Alexandre, Smith, Nicholas L, Benjamin, Emelia, Dehghan, Abbas, Ahluwalia, Tarunveer Singh, Meigs, James, Tracy, Russell, Lindstrom, Sara, Alizadeh, Behrooz Z, Ligthart, Symen, Bis, Josh, Eiriksdottir, Gudny, Gross, Myron, Rainer, Alex, Snieder, Harold, Wilson, James G, Wang, Lu, Dupuis, Josee, Prins, Bram, Vaso, Urmo, Stathopoulou, Maria, Franke, Lude, Lehtimaki, Terho, Koenig, Wolfgang, Jamshidi, Yalda, Siest, Sophie, Abbasi, Ali, Smith, Erin N, Uitterlinden, Andre G, Abdollahi, Mohammadreza, Schnabel, Renate, Schick, Ursula M, Nolte, Ilja M, Kraja, Aldi, Hsu, Yi-Hsiang, Tylee, Daniel S, Zwicker, Alyson, Uher, Rudolf
Publikováno v:
Circulation: Genomic and Precision Medicine, 13(3):e002872. Lippincott Williams and Wilkins Ltd.
Circulation 13(3), 168-271 (2020). doi:10.1161/CIRCGEN.119.002872
Circulation. Genomic and precision medicine, 13(3):e002872. LIPPINCOTT WILLIAMS & WILKINS
CHARGE Inflammation Working Group 2020, ' Interleukin-6 Signaling Effects on Ischemic Stroke and Other Cardiovascular Outcomes : A Mendelian Randomization Study ', Circulation: Genomic and Precision Medicine, vol. 13, no. 3, e002872, pp. E002872 . https://doi.org/10.1161/CIRCGEN.119.002872
Circulation. Genomic and Precision Medicine
Circulation 13(3), 168-271 (2020). doi:10.1161/CIRCGEN.119.002872
Circulation. Genomic and precision medicine, 13(3):e002872. LIPPINCOTT WILLIAMS & WILKINS
CHARGE Inflammation Working Group 2020, ' Interleukin-6 Signaling Effects on Ischemic Stroke and Other Cardiovascular Outcomes : A Mendelian Randomization Study ', Circulation: Genomic and Precision Medicine, vol. 13, no. 3, e002872, pp. E002872 . https://doi.org/10.1161/CIRCGEN.119.002872
Circulation. Genomic and Precision Medicine
BackgroundStudies in humans and experimental models highlight a role of interleukin-6 (IL-6) in cardiovascular disease. Indirect evidence suggests that inhibition of IL-6 signaling could lower risk of coronary artery disease. However, whether such an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc50a791a288a1491917f80d4405dea8
https://research.vu.nl/en/publications/83089aa3-e8cd-4fc3-9c67-b4c1eaaf89c6
https://research.vu.nl/en/publications/83089aa3-e8cd-4fc3-9c67-b4c1eaaf89c6