Zobrazeno 1 - 10
of 16
pro vyhledávání: '"CGI, CpG island"'
Autor:
Lu, Xiaofan, Jiang, Liyun, Zhang, Liya, Zhu, Yue, Hu, Wenjun, Wang, Jiashuo, Ruan, Xinjia, Xu, Zhengbao, Meng, Xiaowei, Gao, Jun, Su, Xiaoping, Yan, Fangrong
Publikováno v:
Neoplasia (New York, N.Y.)
Substantial heterogeneity exists within cervical cancer that is generally infected by human papillomavirus (HPV). However, the most common histological subtype of cervical cancer, cervical squamous cell carcinoma (CSCC), is poorly characterized regar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5bda5131301165092a952cb3bada054f
http://europepmc.org/articles/PMC6658934
http://europepmc.org/articles/PMC6658934
Autor:
Tim De Meyer, Louis Coussement, Maureen Higgins, Elena V. Knatko, Albena T. Dinkova-Kostova, Sandra Steyaert, Charlotte M. Proby, Kevin Roth
Publikováno v:
EBIOMEDICINE
EBioMedicine, Vol 67, Iss, Pp 103383-(2021)
EBioMedicine
EBioMedicine, Vol 67, Iss, Pp 103383-(2021)
EBioMedicine
Background Cutaneous squamous cell carcinomas (cSCC) are among the most common and highly mutated human malignancies. Understanding the impact of DNA methylation in cSCC may provide avenues for new therapeutic strategies. Methods We used reduced-repr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a9a728692e7f11d9c3617585e44f154
https://hdl.handle.net/1854/LU-8741083
https://hdl.handle.net/1854/LU-8741083
Autor:
Qu Lihua, Haitao Liu, Zhongbo Yu, Xiangchen Guan, Shuang Guo, Huang Wei, Fuping Sun, Huiru Zou, Lin Liang, Wei Zhang, Hongrui Yuan, Wang Zeyu
Publikováno v:
The Journal of Biological Chemistry
Epigenetics, such as the dynamic interplay between DNA methylation and demethylation, play diverse roles in critical cellular events. Enzymatic activity at CpG sites, where cytosines are methylated or demethylated, is known to be influenced by the de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fce016580f27f3385e4c44a0d9ace29b
https://doi.org/10.1016/j.jbc.2021.100327
https://doi.org/10.1016/j.jbc.2021.100327
Autor:
Matías A. Avila, María Arechederra, Leticia Colyn, Maite G. Fernandez-Barrena, Carmen Berasain
Publikováno v:
JHEP Reports
Summary Hepatocellular carcinoma (HCC) is a deadly tumour whose causative agents are generally well known, but whose pathogenesis remains poorly understood. Nevertheless, key genetic alterations are emerging from a heterogeneous molecular landscape,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd34b06289cc41bef258ab67c7a43231
https://doi.org/10.1016/j.jhepr.2020.100167
https://doi.org/10.1016/j.jhepr.2020.100167
Autor:
Matthew D. Stachler
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and molecular gastroenterology and hepatology, vol 8, iss 2
Cellular and molecular gastroenterology and hepatology, vol 8, iss 2
Background & Aims Colorectal cancer is an epigenetically heterogeneous disease, however, the extent and spectrum of the CpG island methylator phenotype (CIMP) is not clear. Methods Genome-scale methylation and transcript expression were measured by D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::186f76e85935ebc574906565909230ab
http://europepmc.org/articles/PMC6717931
http://europepmc.org/articles/PMC6717931
Autor:
Leonie Roos, Christopher G. Bell, Veronique Bataille, Tim D. Spector, Massimo Mangino, Johanna K. Sandling, Jordana T. Bell, Daniel Glass, Panos Deloukas
Publikováno v:
Roos, L, Sandling, J K, Bell, C G, Glass, D, Mangino, M, Spector, T D, Deloukas, P, Bataille, V & Bell, J T 2016, ' Higher Naevus Count Exhibits A Distinct DNA Methylation Signature in Healthy Human Skin : Implications for Melanoma ', Journal of Investigative Dermatology . https://doi.org/10.1016/j.jid.2016.11.029
The Journal of Investigative Dermatology
The Journal of Investigative Dermatology
High nevus count is the strongest risk factor for melanoma, and although gene variants have been discovered for both traits, epigenetic variation is unexplored. We investigated 322 healthy human skin DNA methylomes associated with total body nevi cou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4bb0500ce4d14af2b4ac6a36819c74f
https://kclpure.kcl.ac.uk/en/publications/5d679866-7713-462a-b684-db2c97fffa2a
https://kclpure.kcl.ac.uk/en/publications/5d679866-7713-462a-b684-db2c97fffa2a
Publikováno v:
Long, H K, Blackledge, N P & Klose, R J 2013, ' ZF-CxxC domain-containing proteins, CpG islands and the chromatin connection ', Biochemical Society Transactions, vol. 41, no. 3, pp. 727-40 . https://doi.org/10.1042/BST20130028
Biochemical Society Transactions
Biochemical Society Transactions
Vertebrate DNA can be chemically modified by methylation of the 5 position of the cytosine base in the context of CpG dinucleotides. This modification creates a binding site for MBD (methyl-CpG-binding domain) proteins which target chromatin-modifyin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04d23e5886961723d395fb4798c63f76
https://ora.ox.ac.uk/objects/uuid:194ec326-8549-4a6f-a9fd-66f9001fc79c
https://ora.ox.ac.uk/objects/uuid:194ec326-8549-4a6f-a9fd-66f9001fc79c
Autor:
Panos Deloukas, Pelin Akan
Publikováno v:
Gene
Promoters play a central role in gene regulation, yet our power to discriminate them from non-promoter sequences in higher eukaryotes is mainly restricted to those associated with CpG islands. Here, we examined in silico the promoters of 30,954 human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c3263df1c68789cfafd5f62deb54c3a
https://doi.org/10.1016/j.gene.2007.12.011
https://doi.org/10.1016/j.gene.2007.12.011
Autor:
Michele Zampieri, Paola Caiafa, Roberta Calabrese, Maria Giulia Bacalini, Tiziana Guastafierro, Fabio Ciccarone, Claudio Passananti, Mariagrazia Perilli, Anna Reale
Publikováno v:
Biochemical journal (Lond., 1984) (2011).
info:cnr-pdr/source/autori:Zampieri M, Guastafierro T, Calabrese R, Ciccarone F, Bacalini MG, Reale A, Perilli M, Passananti C, Caiafa P./titolo:ADP-ribose polymers localized on Ctcf-Parp1-Dnmt1 complex prevent methylation of Ctcf target sites/doi:/rivista:Biochemical journal (Lond., 1984)/anno:2011/pagina_da:/pagina_a:/intervallo_pagine:/volume
Biochemical Journal
Biochemical Journal, Portland Press, 2012, 441 (2), pp.645-52. ⟨10.1042/BJ20111417⟩
info:cnr-pdr/source/autori:Zampieri M, Guastafierro T, Calabrese R, Ciccarone F, Bacalini MG, Reale A, Perilli M, Passananti C, Caiafa P./titolo:ADP-ribose polymers localized on Ctcf-Parp1-Dnmt1 complex prevent methylation of Ctcf target sites/doi:/rivista:Biochemical journal (Lond., 1984)/anno:2011/pagina_da:/pagina_a:/intervallo_pagine:/volume
Biochemical Journal
Biochemical Journal, Portland Press, 2012, 441 (2), pp.645-52. ⟨10.1042/BJ20111417⟩
International audience; PARylation [poly(ADP-ribosyl)ation] is involved in the maintenance of genomic methylation patterns through its control of Dnmt1 [DNA (cytosine-5)-methyltransferase 1] activity. Our previous findings indicated that Ctcf (CCCTC-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cc9c3e32330951a8c2fb1e73d16fa7e
https://publications.cnr.it/doc/11827
https://publications.cnr.it/doc/11827
Autor:
Tran TO; International Ph.D. Program for Cell Therapy and Regeneration Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.; Hematology and Blood Transfusion Center, Bach Mai Hospital, No.78, Giai Phong street, Hanoi, Viet Nam., Vo TH; Department of Science, School of Science and Computing, South East Technological University, Waterford X91 K0EK, Ireland.; Pharmaceutical and Molecular Biotechnology Research Center (PMBRC), South East Technological University, Waterford X91 K0EK, Ireland., Lam LHT; Department of Pediatrics, Pham Ngoc Thach University of Medicine, Ho Chi Minh city, Viet Nam.; Children's Hospital 1, Ho Chi Minh city, Viet Nam., Le NQK; Professional Master Program in Artificial Intelligence in Medicine, College of Medicine, Taipei Medical University, Taipei 106, Taiwan.; Research Center for Artificial Intelligence in Medicine, Taipei Medical University, Taipei 106, Taiwan.; Translational Imaging Research Center, Taipei Medical University Hospital, Taipei 110, Taiwan.
Publikováno v:
Computational and structural biotechnology journal [Comput Struct Biotechnol J] 2023 Feb 24; Vol. 21, pp. 1921-1929. Date of Electronic Publication: 2023 Feb 24 (Print Publication: 2023).