In Vitro Rescue of the Bile Acid Transport Function of ABCB11 Variants by CFTR Potentiators.

Autor: Mareux, Elodie¹ (AUTHOR), Lapalus, Martine¹ (AUTHOR), Ben Saad, Amel¹ (AUTHOR), Zelli, Renaud² (AUTHOR), Lakli, Mounia¹ (AUTHOR), Riahi, Yosra¹ (AUTHOR), Almes, Marion³ (AUTHOR), Banet, Manon¹ (AUTHOR), Callebaut, Isabelle⁴ (AUTHOR), Decout, Jean-Luc² (AUTHOR), Falguières, Thomas¹ (AUTHOR), Jacquemin, Emmanuel^1,3 (AUTHOR), Gonzales, Emmanuel^1,3 (AUTHOR) emmanuel.gonzales@aphp.fr

Publikováno v: International Journal of Molecular Sciences. Sep2022, Vol. 23 Issue 18, pN.PAG-N.PAG. 14p.

Structure-based discovery of CFTR potentiators and inhibitors.

Autor: Liu F; Laboratory of Membrane Biology and Biophysics, The Rockefeller University, New York, NY 10065, USA.; Dept. of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco CA 94143, USA., Kaplan AL; Dept. of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco CA 94143, USA., Levring J; Laboratory of Membrane Biology and Biophysics, The Rockefeller University, New York, NY 10065, USA., Einsiedel J; Dept. of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander University Erlangen-Nürnberg, Nikolaus-Fiebiger-Straße 10, D-91058 Erlangen, Germany., Tiedt S; Dept. of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander University Erlangen-Nürnberg, Nikolaus-Fiebiger-Straße 10, D-91058 Erlangen, Germany., Distler K; Dept. of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander University Erlangen-Nürnberg, Nikolaus-Fiebiger-Straße 10, D-91058 Erlangen, Germany., Omattage NS; Laboratory of Membrane Biology and Biophysics, The Rockefeller University, New York, NY 10065, USA.; Current address: Department of Infectious Diseases, Genentech, Inc., South San Francisco, CA 94080, USA., Kondratov IS; Enamine Ltd. (www.enamine.net), Chervonotkatska Street 78, Kyїv 02094, Ukraine.; V.P. Kukhar Institute of Bioorganic Chemistry & Petrochemistry, National Academy of Sciences of Ukraine, Murmanska Street 1, Kyїv 02660, Ukraine., Moroz YS; Chemspace (www.chem-space.com), Chervonotkatska Street 85, Kyїv 02094, Ukraine.; Taras Shevchenko National University of Kyїv, Volodymyrska Street 60, Kyїv 01601, Ukraine., Pietz HL; Laboratory of Membrane Biology and Biophysics, The Rockefeller University, New York, NY 10065, USA., Irwin JJ; Dept. of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco CA 94143, USA., Gmeiner P; Dept. of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander University Erlangen-Nürnberg, Nikolaus-Fiebiger-Straße 10, D-91058 Erlangen, Germany., Shoichet BK; Dept. of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco CA 94143, USA., Chen J; Laboratory of Membrane Biology and Biophysics, The Rockefeller University, New York, NY 10065, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Mar 11. Date of Electronic Publication: 2024 Mar 11.

New Insights into the Binding Features of F508del CFTR Potentiators: A Molecular Docking, Pharmacophore Mapping and QSAR Analysis Approach

Autor: Giada Righetti, Monica Casale, Michele Tonelli, Nara Liessi, Paola Fossa, Nicoletta Pedemonte, Enrico Millo, Elena Cichero

Publikováno v: Pharmaceuticals, Vol 13, Iss 12, p 445 (2020)

Cystic fibrosis (CF) is the autosomal recessive disorder most recurrent in Caucasian populations. To combat this disease, many life-prolonging therapies are required and deeply investigated, including the development of the so-called cystic fibrosis

Externí odkaz: https://doaj.org/article/1e180c37a3f34af1978c5797f69441b3

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