Combination of Correctors Rescues CFTR Transmembrane-Domain Mutants by Mitigating their Interactions with Proteostasis

Autor: Liudmila Cebotaru, Inna Sabirzhanova, Miquéias Lopes-Pacheco, Daniele Rapino, Clément Boinot

Publikováno v: Cellular Physiology and Biochemistry, Vol 41, Iss 6, Pp 2194-2210 (2017)
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Background/Aims: Premature degradation of mutated cystic fibrosis transmembrane conductance regulator (CFTR) protein causes cystic fibrosis (CF), the commonest Mendelian disease in Caucasians. Despite recent advances in precision medicines for CF pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9805f3caab76ae25cfc1fea5df0af1c5
https://doi.org/10.1159/000475578

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