Zobrazeno 1 - 10
of 23
pro vyhledávání: '"CFP, Cyan fluorescent protein"'
Publikováno v:
The Journal of Biological Chemistry
Reactive oxygen species are key factors that strongly affect the cellular redox state and regulate various physiological and cellular phenomena. To monitor changes in the redox state, we previously developed fluorescent redox sensors named Re-Q, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::becef2d680d3fc03b5ca82792cac9340
http://europepmc.org/articles/PMC8487062
http://europepmc.org/articles/PMC8487062
Autor:
Kazuki Uchiyama, Ryunosuke Endo, Sei-Young Lim, Takahiro Adachi, Koji Uchida, Masanori Itakura
Publikováno v:
The Journal of Biological Chemistry
Natural antibodies, predominantly immunoglobulin M (IgM), play an important role in the defense against pathogens and in maintaining homeostasis against oxidized molecules known as oxidation-specific epitopes, such as those contained in oxidized low-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c68bed2b2f19f4e994a0f9d64ddee120
https://pubmed.ncbi.nlm.nih.gov/33839149
https://pubmed.ncbi.nlm.nih.gov/33839149
Autor:
Maja Malnar, Angela Bachi, Helena H. Chowdhury, Anemari Horvat, Patrizia D’Adamo, Antonia Gurgone, Saša Trkov Bobnar, Marko Muhič, Lorenzo Piemonti, Maria Lidia Mignogna, Michela Masetti, Jelena Velebit, Veronica Bianchi, Robert Zorec, Matjaž Stenovec, Alessia Mercalli, Katja Fink, Sara Belloli, Stefano Taverna, Maja Potokar, Marko Kreft, Rosa Maria Moresco, Nina Vardjan, Maddalena Ripamonti, Umberto Restuccia
Publikováno v:
Metabolism
Metabolism, clinical and experimental
116 (2021): 154463. doi:10.1016/j.metabol.2020.154463
info:cnr-pdr/source/autori:D'Adamo P.; Horvat A.; Gurgone A.; Mignogna M.L.; Bianchi V.; Masetti M.; Ripamonti M.; Taverna S.; Velebit J.; Malnar M.; Muhic M.; Fink K.; Bachi A.; Restuccia U.; Belloli S.; Moresco R.M.; Mercalli A.; Piemonti L.; Potokar M.; Bobnar S.T.; Kreft M.; Chowdhury H.H.; Stenovec M.; Vardjan N.; Zorec R./titolo:Inhibiting glycolysis rescues memory impairment in an intellectual disability Gdi1-null mouse/doi:10.1016%2Fj.metabol.2020.154463/rivista:Metabolism, clinical and experimental (Print)/anno:2021/pagina_da:154463/pagina_a:/intervallo_pagine:154463/volume:116
Metabolism, clinical and experimental
116 (2021): 154463. doi:10.1016/j.metabol.2020.154463
info:cnr-pdr/source/autori:D'Adamo P.; Horvat A.; Gurgone A.; Mignogna M.L.; Bianchi V.; Masetti M.; Ripamonti M.; Taverna S.; Velebit J.; Malnar M.; Muhic M.; Fink K.; Bachi A.; Restuccia U.; Belloli S.; Moresco R.M.; Mercalli A.; Piemonti L.; Potokar M.; Bobnar S.T.; Kreft M.; Chowdhury H.H.; Stenovec M.; Vardjan N.; Zorec R./titolo:Inhibiting glycolysis rescues memory impairment in an intellectual disability Gdi1-null mouse/doi:10.1016%2Fj.metabol.2020.154463/rivista:Metabolism, clinical and experimental (Print)/anno:2021/pagina_da:154463/pagina_a:/intervallo_pagine:154463/volume:116
Objectives GDI1 gene encodes for αGDI, a protein controlling the cycling of small GTPases, reputed to orchestrate vesicle trafficking. Mutations in human GDI1 are responsible for intellectual disability (ID). In mice with ablated Gdi1, a model of ID
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2b634b090f73e01f5e64f5a419978ac
http://europepmc.org/articles/PMC7871014
http://europepmc.org/articles/PMC7871014
Publikováno v:
The Journal of Biological Chemistry
Ca2+/calmodulin-dependent inactivation (CDI) of CaV channels is a critical regulatory process that tunes the kinetics of Ca2+ entry for different cell types and physiologic responses. CDI is mediated by calmodulin (CaM), which is bound to the IQ doma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a9b4f8af3eaa905ed80ea2ad9b94d93e
https://pubmed.ncbi.nlm.nih.gov/33667546
https://pubmed.ncbi.nlm.nih.gov/33667546
Autor:
P.A. Shenoy, Michelle L. Halls, Luigi Aurelio, Tim Quach, Joshua W. Conner, Quynh N. Mai, Stephen J. Hill, Thomas P. Davis, Meritxell Canals, Christopher J.H. Porter, Nigel W. Bunnett, Arisbel B. Gondin, Cameron J. Nowell, Holly R. Yeatman, Bim Graham, Nicholas A. Veldhuis, Jeffri S. Retamal, Daniel P. Poole, Stephen J. Briddon
Publikováno v:
The Journal of Biological Chemistry
G-protein-coupled receptors (GPCRs) are traditionally known for signaling at the plasma membrane, but they can also signal from endosomes after internalization to control important pathophysiological processes. In spinal neurons, sustained endosomal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0b62515ab0e736f2319a04571ef82b6
https://pubmed.ncbi.nlm.nih.gov/33515548
https://pubmed.ncbi.nlm.nih.gov/33515548
Autor:
Marissa Ashton, Martin Weber, Mark P. Jedrychowski, Thimo Kurz, Daniel Finley, Hai Ngu, Eric J. Brown, Alexandra M. Whiteley, Stefanie A. H. de Poot, Mervyn J. Monteiro, Amy Easton, John Szpyt, Sara L. Dominguez, Steven P. Gygi, Joao A. Paulo, Miguel A. Prado
Publikováno v:
The Journal of Biological Chemistry
Familial neurodegenerative diseases commonly involve mutations that result in either aberrant proteins or dysfunctional components of the proteolytic machinery that act on aberrant proteins. UBQLN2 is a ubiquitin receptor of the UBL/UBA family that b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4817136e59d4fb8136c5a4764e71e673
https://doi.org/10.1101/2020.02.22.956524
https://doi.org/10.1101/2020.02.22.956524
Autor:
Guangyu Wu, Mostafa Khater, Gang Hu, Xin Xu, Zhe Wei, Alvin V. Terry, Yinquan Fang, Sean X. Naughton
Publikováno v:
The Journal of Biological Chemistry
G protein–coupled receptors (GPCRs) are important modulators of synaptic functions. A fundamental but poorly addressed question in neurobiology is how targeted GPCR trafficking is achieved. Rab GTPases are the master regulators of vesicle-mediated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3c3a1727eda96f5ce61b28961ea2e20
https://doi.org/10.1016/j.jbc.2021.100517
https://doi.org/10.1016/j.jbc.2021.100517
Autor:
Kishalay Mitra, Priyanka Devi Pantula, Ajith Karunarathne, Dinesh Kankanamge, Lopamudra Giri, Mithila Tennakoon, Sithurandi Ubeysinghe
Publikováno v:
The Journal of Biological Chemistry
Phospholipase C β (PLCβ), which is activated by the Gq family of heterotrimeric G proteins, hydrolyzes the inner membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2), generating diacylglycerol and inositol 1,4,5-triphosphate (IP3). Because G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b5b0d1b248bd704516635781a56e6bd
https://doi.org/10.1016/j.jbc.2021.100702
https://doi.org/10.1016/j.jbc.2021.100702
Autor:
Per Olof Berggren, Shao-Nian Yang
Publikováno v:
Pharmacology & Therapeutics
Diabetes develops due to deficient functional β cell mass, insulin resistance, or both. Yet, various challenges in understanding the mechanisms underlying diabetes development in vivo remain to be overcome owing to the lack of appropriate intravital
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fa0cc54977ee585479065e69678f400
https://pubmed.ncbi.nlm.nih.gov/30677477
https://pubmed.ncbi.nlm.nih.gov/30677477
Autor:
Alexandre A. Mironov, Tor Erik Rusten, Galina V. Beznoussenko, Thomas Vaccari, Harald Stenmark, David Bilder, Valeria Mastrodonato, Pierpaolo Ginefra, Elena Morelli
Publikováno v:
Autophagy
Autophagy, vol 10, iss 12
Autophagy, vol 10, iss 12
How autophagic degradation is linked to endosomal trafficking routes is little known. Here we screened a collection of uncharacterized Drosophila mutants affecting membrane transport to identify new genes that also have a role in autophagy. We isolat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcde934b1ebd3794834512bd341d4be7
http://europepmc.org/articles/PMC4502674
http://europepmc.org/articles/PMC4502674