Zobrazeno 1 - 10
of 1 144
pro vyhledávání: '"CFH"'
Autor:
Shigekazu Kurihara, Akinori Yamaguchi, Kosuke Sonoda, Yosuke Yamada, Makoto Harada, Koji Hashimoto, Hisashi Shimojo, Yoichiro Ikeda, Yuji Kamijo
Publikováno v:
BMC Nephrology, Vol 25, Iss 1, Pp 1-10 (2024)
Abstract Background No reports have shown histological changes before and after anti-C5 monoclonal antibody treatment in patients with atypical hemolytic uremic syndrome (aHUS). Here, we report a rare case of complement-mediated aHUS with a complemen
Externí odkaz:
https://doaj.org/article/b011f8b76e914462afcb34a0f76927ad
Autor:
Fazliana Ismail, Sarni Mat Junit, Lee Ching Chin, Jaime Jacqueline Jayapalan, Visvaraja Subrayan
Publikováno v:
Egyptian Journal of Medical Human Genetics, Vol 25, Iss 1, Pp 1-11 (2024)
Abstract Background Despite extensive research efforts, understanding the precise causes and molecular underpinnings of age-related macular degeneration (AMD) remains elusive. Exploring different populations becomes crucial to establish conclusive in
Externí odkaz:
https://doaj.org/article/680dfc430ae843838d9b6bbfa27dd3cf
Autor:
Zhongli Wang, Tingting Zhang, Xinyu Wang, Jianlong Zhai, Lili He, Sai Ma, Qingjuan Zuo, Guorui Zhang, Yifang Guo
Publikováno v:
Renal Failure, Vol 46, Iss 2 (2024)
Objective The aim of this study was to investigate the potential importance of complement system activation, with particular emphasis on the complement alternative pathway (AP), in the pathogenesis of hypertensive renal damage.Methods Serum complemen
Externí odkaz:
https://doaj.org/article/3ae8cd875aaa4a5793f5b4afb573a1ab
Autor:
Jingyu Gao, Yongzhang Wu, Jieming Yu, Yinbin Qiu, Tiantian Yi, Chaochao Luo, Junxiao Zhang, Gary Lu, Xu Li, Fu Xiong, Xuedong Wu, Xinghua Pan
Publikováno v:
Cancer Medicine, Vol 13, Iss 13, Pp n/a-n/a (2024)
Abstract Background Germline mutations have been identified in a small number of hereditary cancers, but the genetic predisposition for many familial cancers remains to be elucidated. Methods This study identified a Chinese pedigree that presented di
Externí odkaz:
https://doaj.org/article/9919f1d1895e40e4a78629c75d3d20dc
Autor:
Todor Tschongov, Swagata Konwar, Andreas Busch, Christian Sievert, Andrea Hartmann, Marina Noris, Sara Gastoldi, Sistiana Aiello, Andreas Schaaf, Jens Panse, Peter F. Zipfel, Paulina Dabrowska-Schlepp, Karsten Häffner
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Most drugs that target the complement system are designed to inhibit the complement pathway at either the proximal or terminal levels. The use of a natural complement regulator such as factor H (FH) could provide a superior treatment option by restor
Externí odkaz:
https://doaj.org/article/316e4e983cf84c93b83284c77b9c1ed8
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
BackgroundIdiopathic pulmonary fibrosis (IPF) is a fatal disease of unknown etiology with a poor prognosis, characterized by a lack of effective diagnostic and therapeutic interventions. The role of immunity in the pathogenesis of IPF is significant,
Externí odkaz:
https://doaj.org/article/9412d1d6a7fb41dfb0f4171585e05ccb
Publikováno v:
Biomedicines, Vol 12, Iss 7, p 1479 (2024)
One of the major causes of vision impairment among elderly people in developed nations is age-related macular degeneration (AMD). The distinctive features of AMD are the accumulation of extracellular deposits called drusen and the gradual deteriorati
Externí odkaz:
https://doaj.org/article/14e74bcd22b441ca9e082b32d91bf307
Publikováno v:
Journal of Ophthalmology, Iss 4, Pp 26-33 (2023)
Background: Age-related macular degeneration (AMD) is one of the most common disorders that can lead to total central vision loss after choroidal neovascularization or geographic atrophy (GA). Because the genetic component of the disease plays an imp
Externí odkaz:
https://doaj.org/article/38e6039581174d1bbf800d00e3c86ed3
Autor:
Dzastina Cebatoriene, Alvita Vilkeviciute, Greta Gedvilaite, Akvile Bruzaite, Loresa Kriauciuniene, Dalia Zaliuniene, Rasa Liutkeviciene
Publikováno v:
Biomedicines, Vol 12, Iss 5, p 948 (2024)
Background: Age-related macular degeneration (AMD) is a major global health problem as it is the leading cause of irreversible loss of central vision in the aging population. Av-vascular endothelial growth factor (anti-VEGF) therapies have been shown
Externí odkaz:
https://doaj.org/article/9a9d1b6641cc4513b366cb4c4d27a15d
Autor:
Qian Li, Xinxin Kong, Minle Tian, Jing Wang, Zhenle Yang, Lichun Yu, Suwen Liu, Cong Wang, Xiaoyuan Wang, Shuzhen Sun
Publikováno v:
Renal Failure, Vol 44, Iss 1, Pp 1061-1069 (2022)
Objective To explore the clinical characteristics, treatment protocol and prognosis of children with anti-complement factor H (CFH) autoantibody (Ab)-associated hemolytic uremic syndrome (HUS).Methods Clinical data of 8 patients with anti-CFH Ab-asso
Externí odkaz:
https://doaj.org/article/a0967b3740b64794abf01a3d3e7067d8