Cholesteryl ester storage disease: complex molecular effects of chronic lovastatin therapy.

Autor: R Levy, RE Ostlund, Jr, G Schonfeld, P Wong, CF Semenkovich

Publikováno v: Journal of Lipid Research, Vol 33, Iss 7, Pp 1005-1015 (1992)

To better characterize the in vivo effects of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibition on human lipid metabolism, an adolescent male with cholesteryl ester storage disease (CESD) was treated chronically with lovastatin. Th

Externí odkaz: https://doaj.org/article/7e0e8d9a4362460f81aac661059db77e

Brown fat ATP-citrate lyase links carbohydrate availability to thermogenesis and guards against metabolic stress.

Autor: Korobkina ED; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Calejman CM; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Haley JA; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Kelly ME; Department of Biological Chemistry, University of California Irvine, Irvine, CA, USA., Li H; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Gaughan M; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Chen Q; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Pepper HL; Aging + Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA., Ahmad H; Aging + Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA., Boucher A; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Fluharty SM; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Lin TY; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Lotun A; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Peura J; Division of Hematology-Oncology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Trefely S; Department of Cancer Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Green CR; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA., Vo P; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Semenkovich CF; Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St. Louis, MO, USA., Pitarresi JR; Division of Hematology-Oncology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA., Spinelli JB; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Aydemir O; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Metallo CM; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.; Molecular and Cellular Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA., Lynes MD; MaineHealth Institute for Research, Scarborough, ME, USA., Jang C; Department of Biological Chemistry, University of California Irvine, Irvine, CA, USA., Snyder NW; Aging + Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA., Wellen KE; Department of Cancer Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Guertin DA; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA. david.guertin@umassmed.edu.; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA. david.guertin@umassmed.edu.

Publikováno v: Nature metabolism [Nat Metab] 2024 Nov; Vol. 6 (11), pp. 2187-2202. Date of Electronic Publication: 2024 Oct 14.

De novo lipid synthesis in cardiovascular tissue and disease.

Autor: Khan TJ; Washington University School of Medicine, Department of Surgery, Section of Vascular Surgery, St. Louis, MO, USA., Semenkovich CF; Washington University School of Medicine, Department of Medicine, Division of Endocrinology, Metabolism and Lipid Research, St. Louis, MO, USA; Washington University School of Medicine, Department of Cell Biology and Physiology, St. Louis, MO, USA., Zayed MA; Washington University School of Medicine, Department of Surgery, Section of Vascular Surgery, St. Louis, MO, USA; Washington University School of Medicine, Department of Surgery, Division of Surgical Sciences, St. Louis, MO, USA; Washington University School of Medicine, Department of Radiology, St. Louis, MO, USA; Washington University School of Medicine, Division of Molecular Cell Biology, St. Louis, MO, USA; Washington University, McKelvey School of Engineering, Department of Biomedical Engineering, St. Louis, MO, USA; Veterans Affairs St. Louis Health Care System, St. Louis, MO, USA. Electronic address: zayedm@wustl.edu.

Publikováno v: Atherosclerosis [Atherosclerosis] 2025 Jan; Vol. 400, pp. 119066. Date of Electronic Publication: 2024 Nov 26.

Depalmitoylation and cell physiology: APT1 as a mediator of metabolic signals.

Autor: Speck SL; Division of Endocrinology, Metabolism and Lipid Research, Washington University in St. Louis, St. Louis, Missouri, United States., Wei X; Division of Endocrinology, Metabolism and Lipid Research, Washington University in St. Louis, St. Louis, Missouri, United States., Semenkovich CF; Division of Endocrinology, Metabolism and Lipid Research, Washington University in St. Louis, St. Louis, Missouri, United States.

Publikováno v: American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2024 Apr 01; Vol. 326 (4), pp. C1034-C1041. Date of Electronic Publication: 2024 Feb 12.

Decreased sarcoplasmic reticulum phospholipids in human skeletal muscle are associated with metabolic syndrome.

Autor: Adamson SE; Division of Endocrinology, Metabolism & Lipid Research, Washington University, St Louis, MO, USA., Adak S; Division of Endocrinology, Metabolism & Lipid Research, Washington University, St Louis, MO, USA., Petersen MC; Division of Endocrinology, Metabolism & Lipid Research, Washington University, St Louis, MO, USA., Higgins D; Division of Endocrinology, Metabolism & Lipid Research, Washington University, St Louis, MO, USA., Spears LD; Division of Endocrinology, Metabolism & Lipid Research, Washington University, St Louis, MO, USA., Zhang RM; Division of Endocrinology, Metabolism & Lipid Research, Washington University, St Louis, MO, USA., Cedeno A; Division of Endocrinology, Metabolism & Lipid Research, Washington University, St Louis, MO, USA., McKee A; Division of Endocrinology, Metabolism & Lipid Research, Washington University, St Louis, MO, USA., Kumar A; Division of Endocrinology, Metabolism & Lipid Research, Washington University, St Louis, MO, USA., Singh S; Division of Endocrinology, Metabolism & Lipid Research, Washington University, St Louis, MO, USA., Hsu FF; Division of Endocrinology, Metabolism & Lipid Research, Washington University, St Louis, MO, USA., McGill JB; Division of Endocrinology, Metabolism & Lipid Research, Washington University, St Louis, MO, USA., Semenkovich CF; Division of Endocrinology, Metabolism & Lipid Research, Washington University, St Louis, MO, USA; Department of Cell Biology & Physiology, Washington University, St Louis, MO, USA. Electronic address: csemenko@wustl.edu.

Publikováno v: Journal of lipid research [J Lipid Res] 2024 Mar; Vol. 65 (3), pp. 100519. Date of Electronic Publication: 2024 Feb 13.