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Silencing of ceramide synthase 2 in hepatocytes modulates plasma ceramide biomarkers predictive of cardiovascular death

Autor: Christer S. Ejsing, Sandra F Gallego, Anthony H. Futerman, Richard R. Sprenger, Ole N. Jensen, Nanna Albæk, Steffen Schmidt, Marie W. Lindholm, Charlotte Øverup, Yael Pewzner-Jung, Sergey Kovalchuk, Iris D. Zelnik

Publikováno v: Mol Ther
Schmidt, S, Gallego, S F, Zelnik, I D, Kovalchuk, S, Albæk, N, Sprenger, R R, Øverup, C, Pewzner-Jung, Y, Futerman, A H, Lindholm, M W, Jensen, O N & Ejsing, C S 2022, ' Silencing of ceramide synthase 2 in hepatocytes modulates plasma ceramide biomarkers predictive of cardiovascular death ', Molecular Therapy, vol. 30, no. 4, pp. 1661-1674 . https://doi.org/10.1016/j.ymthe.2021.08.021

Emerging clinical data show that three ceramide molecules, Cer d18:1/16:0, Cer d18:1/24:1, and Cer d18:1/24:0, are biomarkers of a fatal outcome in patients with cardiovascular disease. This finding raises basic questions about their metabolic origin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8b0e637383248c3671fcfcbf8c482c6
https://doi.org/10.1016/j.ymthe.2021.08.021

Ceramide Synthase 2 Null Mice Are Protected from Ovalbumin-Induced Asthma with Higher T Cell Receptor Signal Strength in CD4+ T Cells

Autor: Sun-Hye Shin, Kyung-Ah Cho, Hee-Soo Yoon, So-Yeon Kim, Hee-Yeon Kim, Yael Pewzner-Jung, Sung-Ae Jung, Woo-Jae Park, Anthony H. Futerman, Joo-Won Park

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 5, p 2713 (2021)

(1) Background: six mammalian ceramide synthases (CerS1–6) determine the acyl chain length of sphingolipids (SLs). Although ceramide levels are increased in murine allergic asthma models and in asthmatic patients, the precise role of SLs with speci

Externí odkaz: https://doaj.org/article/e4c948c8fbbe435285f31957e078f9f7

Sphingolipids in Alzheimer's disease, how can we target them?

Autor: Erhard Bieberich, Jochen Walter, Sandra den Hoedt, Monique T. Mulder, Mario Losen, Caterina Giovagnoni, Lars Visseren, Anna-Lena Scheithauer, Pilar Martinez-Martinez, Simone M. Crivelli, Nienke M. de Wit, Helga E. de Vries

Publikováno v: Crivelli, S M, Giovagnoni, C, Visseren, L, Scheithauer, A-L, de Wit, N, den Hoedt, S, Losen, M, Mulder, M T, Walter, J, de Vries, H E, Bieberich, E & Martinez-Martinez, P 2020, ' Sphingolipids in Alzheimer's disease, how can we target them? ', Advanced Drug Delivery Reviews, vol. 159, pp. 214-231 . https://doi.org/10.1016/j.addr.2019.12.003
Advanced Drug Delivery Reviews, 159, 214-231. Elsevier

Altered levels of sphingolipids and their metabolites in the brain, and the related downstream effects on neuronal homeostasis and the immune system, provide a framework for understanding mechanisms in neurodegenerative disorders and for developing n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdc52d6b63486f0d3724ea03709659cb
https://pure.eur.nl/en/publications/b16984ac-dc9d-46e6-adb9-6b3b28f34874

Critical Role for Very-Long Chain Sphingolipids in Invariant Natural Killer T Cell Development and Homeostasis

Autor: Ashish Saroha, Yael Pewzner-Jung, Natalia S. Ferreira, Piyush Sharma, Youenn Jouan, Samuel L. Kelly, Ester Feldmesser, Alfred H. Merrill, François Trottein, Christophe Paget, Karl S. Lang, Anthony H. Futerman

Publikováno v: Frontiers in Immunology, Vol 8 (2017)

The role of sphingolipids (SLs) in the immune system has come under increasing scrutiny recently due to the emerging contributions that these important membrane components play in regulating a variety of immunological processes. The acyl chain length

Externí odkaz: https://doaj.org/article/2ff54ec67aa34c3eaf5284d5efdd1e00